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Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients.
Int J Impot Res. 2003 Oct; 15(5):314-7.IJ

Abstract

The association between different antihypertensive drugs and erectile dysfunction (ED) was examined in a cohort of type II diabetes patients identified in the UK General Practice Research Database (GPRD). The GPRD contains details of diagnoses, prescribing, investigations, risk factors, outcomes, and hospital referrals, together with basic demographic information for approximately six million patients from more than 450 representative general practices throughout the UK. A total of 634 cases and 2526 controls were included for analysis. Unconditional logistic regression analysis was performed to assess the risk of ED after adjusting for age at diabetes diagnosis date, cigarette smoking, depression, glycemic control, use of HMG-CoA reductase inhibitors, use of histamine receptor antagonists, use of digitalis medicines, and use of nitrates. Increased risk of ED was observed among patients taking the following antihypertensives: ACE inhibitors (OR=1.47, 95% CI=1.21, 1.80) and alpha blockers (OR=1.54, 95% CI=1.11, 2.12). However, we identified a nearly 30% reduction in risk among patients on diuretics (OR=0.73, 95% CI=0.54, 0.99). No statistically significant increase in risk was observed among users of beta blockers and calcium channel blockers (OR=1.05, 95% CI=0.85, 1.31) and (OR=1.14, 95% CI=0.91, 1.43), respectively. The results of this study confirm the strong and recognized effect of comorbidities in a diabetic population, but also require additional experimental and observational studies to further understand the potential benefit of diuretics and other ED treatments such as PDE5 inhibitors.

Authors+Show Affiliations

Worldwide Epidemiology, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA. Willy.A.Blumentals@gsk.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14562130

Citation

Blumentals, W A., et al. "Antihypertensive Treatment and Erectile Dysfunction in a Cohort of Type II Diabetes Patients." International Journal of Impotence Research, vol. 15, no. 5, 2003, pp. 314-7.
Blumentals WA, Brown RR, Gomez-Caminero A. Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients. Int J Impot Res. 2003;15(5):314-7.
Blumentals, W. A., Brown, R. R., & Gomez-Caminero, A. (2003). Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients. International Journal of Impotence Research, 15(5), 314-7.
Blumentals WA, Brown RR, Gomez-Caminero A. Antihypertensive Treatment and Erectile Dysfunction in a Cohort of Type II Diabetes Patients. Int J Impot Res. 2003;15(5):314-7. PubMed PMID: 14562130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients. AU - Blumentals,W A, AU - Brown,R R, AU - Gomez-Caminero,A, PY - 2003/10/17/pubmed PY - 2004/7/20/medline PY - 2003/10/17/entrez SP - 314 EP - 7 JF - International journal of impotence research JO - Int. J. Impot. Res. VL - 15 IS - 5 N2 - The association between different antihypertensive drugs and erectile dysfunction (ED) was examined in a cohort of type II diabetes patients identified in the UK General Practice Research Database (GPRD). The GPRD contains details of diagnoses, prescribing, investigations, risk factors, outcomes, and hospital referrals, together with basic demographic information for approximately six million patients from more than 450 representative general practices throughout the UK. A total of 634 cases and 2526 controls were included for analysis. Unconditional logistic regression analysis was performed to assess the risk of ED after adjusting for age at diabetes diagnosis date, cigarette smoking, depression, glycemic control, use of HMG-CoA reductase inhibitors, use of histamine receptor antagonists, use of digitalis medicines, and use of nitrates. Increased risk of ED was observed among patients taking the following antihypertensives: ACE inhibitors (OR=1.47, 95% CI=1.21, 1.80) and alpha blockers (OR=1.54, 95% CI=1.11, 2.12). However, we identified a nearly 30% reduction in risk among patients on diuretics (OR=0.73, 95% CI=0.54, 0.99). No statistically significant increase in risk was observed among users of beta blockers and calcium channel blockers (OR=1.05, 95% CI=0.85, 1.31) and (OR=1.14, 95% CI=0.91, 1.43), respectively. The results of this study confirm the strong and recognized effect of comorbidities in a diabetic population, but also require additional experimental and observational studies to further understand the potential benefit of diuretics and other ED treatments such as PDE5 inhibitors. SN - 0955-9930 UR - https://www.unboundmedicine.com/medline/citation/14562130/Antihypertensive_treatment_and_erectile_dysfunction_in_a_cohort_of_type_II_diabetes_patients_ L2 - http://dx.doi.org/10.1038/sj.ijir.3901041 DB - PRIME DP - Unbound Medicine ER -