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Four-year incidence of allergic sensitization among schoolchildren in a community where allergy to cat and dog dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group.
J Allergy Clin Immunol. 2003 Oct; 112(4):747-54.JA

Abstract

BACKGROUND

Exposure to high levels of cat allergen might prevent sensitization.

OBJECTIVE

We sought to measure the incidence of allergic sensitization among schoolchildren living in a dust mite- and cockroach-free environment and the associated risk factors.

METHODS

In 1996, a longitudinal cohort was established in northern Sweden, including 2454 children aged 7 to 8 years. Children were skin tested, and the testing was repeated 4 years later. Questionnaires were completed yearly. Participation was 88% both in 1996 and 2000.

RESULTS

The prevalence of positive skin test results increased from 20.6% at age 7 and 8 years to 30.4% at age 11 and 12 years, a cumulative incidence of 13.8%, and was significantly higher among boys. The incidence was highest for cat (6.0%), timothy grass (5.9%), dog (4.9%), and birch (3.6%). A family history of allergy was the major risk factor for both a positive skin test response at age 7 and 8 years (odds ratio [OR], 1.69; 95% CI, 1.36-2.10) and for development of a positive skin test response over the next 4 years (OR, 1.67; 95% CI, 1.23-2.28). A significant inverse association between cat and dog ownership and the prevalence of type 1 allergy was found, particularly for those children who had lived with a cat both before age 7 and 8 years and during the next 4 years (OR, 0.44; 95% CI, 0.31-0.61). A similar pattern, although not significant, was found for incident cases.

CONCLUSION

The high incidence of type 1 allergy at this age was similar to reports from communities with mite and cockroach allergen. Despite cat and dog being the most common allergens of sensitization, keeping these animals at home was not associated with an increased risk for sensitization.

Authors+Show Affiliations

Department of Medicine, Sunderby Central Hospital of Norrbotten, Luleå, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14564356

Citation

Rönmark, Eva, et al. "Four-year Incidence of Allergic Sensitization Among Schoolchildren in a Community Where Allergy to Cat and Dog Dominates Sensitization: Report From the Obstructive Lung Disease in Northern Sweden Study Group." The Journal of Allergy and Clinical Immunology, vol. 112, no. 4, 2003, pp. 747-54.
Rönmark E, Perzanowski M, Platts-Mills T, et al. Four-year incidence of allergic sensitization among schoolchildren in a community where allergy to cat and dog dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group. J Allergy Clin Immunol. 2003;112(4):747-54.
Rönmark, E., Perzanowski, M., Platts-Mills, T., & Lundbäck, B. (2003). Four-year incidence of allergic sensitization among schoolchildren in a community where allergy to cat and dog dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group. The Journal of Allergy and Clinical Immunology, 112(4), 747-54.
Rönmark E, et al. Four-year Incidence of Allergic Sensitization Among Schoolchildren in a Community Where Allergy to Cat and Dog Dominates Sensitization: Report From the Obstructive Lung Disease in Northern Sweden Study Group. J Allergy Clin Immunol. 2003;112(4):747-54. PubMed PMID: 14564356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four-year incidence of allergic sensitization among schoolchildren in a community where allergy to cat and dog dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group. AU - Rönmark,Eva, AU - Perzanowski,Matthew, AU - Platts-Mills,Thomas, AU - Lundbäck,Bo, AU - ,, PY - 2003/10/18/pubmed PY - 2003/11/11/medline PY - 2003/10/18/entrez SP - 747 EP - 54 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 112 IS - 4 N2 - BACKGROUND: Exposure to high levels of cat allergen might prevent sensitization. OBJECTIVE: We sought to measure the incidence of allergic sensitization among schoolchildren living in a dust mite- and cockroach-free environment and the associated risk factors. METHODS: In 1996, a longitudinal cohort was established in northern Sweden, including 2454 children aged 7 to 8 years. Children were skin tested, and the testing was repeated 4 years later. Questionnaires were completed yearly. Participation was 88% both in 1996 and 2000. RESULTS: The prevalence of positive skin test results increased from 20.6% at age 7 and 8 years to 30.4% at age 11 and 12 years, a cumulative incidence of 13.8%, and was significantly higher among boys. The incidence was highest for cat (6.0%), timothy grass (5.9%), dog (4.9%), and birch (3.6%). A family history of allergy was the major risk factor for both a positive skin test response at age 7 and 8 years (odds ratio [OR], 1.69; 95% CI, 1.36-2.10) and for development of a positive skin test response over the next 4 years (OR, 1.67; 95% CI, 1.23-2.28). A significant inverse association between cat and dog ownership and the prevalence of type 1 allergy was found, particularly for those children who had lived with a cat both before age 7 and 8 years and during the next 4 years (OR, 0.44; 95% CI, 0.31-0.61). A similar pattern, although not significant, was found for incident cases. CONCLUSION: The high incidence of type 1 allergy at this age was similar to reports from communities with mite and cockroach allergen. Despite cat and dog being the most common allergens of sensitization, keeping these animals at home was not associated with an increased risk for sensitization. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/14564356/Four_year_incidence_of_allergic_sensitization_among_schoolchildren_in_a_community_where_allergy_to_cat_and_dog_dominates_sensitization:_report_from_the_Obstructive_Lung_Disease_in_Northern_Sweden_Study_Group_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674903018669 DB - PRIME DP - Unbound Medicine ER -