Tags

Type your tag names separated by a space and hit enter

[Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice].
Sheng Li Xue Bao. 2003 Oct 25; 55(5):571-6.SL

Abstract

Iron plays a key role in Parkinson s disease (PD). To illustrate the mechanism underlying the increase of iron in substantia nigra (SN) in PD, changes of the expression of divalent metal transporter 1 (DMT1) and iron content were examined in SN in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated mice using immunohistochemistry and histochemistry respectively. Following MPTP treatment for 3 d, elevated iron staining was found in SN. A further increase in iron content was observed after 7 d. In these lesioned animals, tyrosine hydroxylase-immunoreactive DA neurons exhibited a decrease in number and morphological changes as well. There were two isoforms of DMT1 expressed in SN of mice. After MPTP treatment, the expression of DMT1 without IRE form increased in either group, whereas DMT1 with IRE form increased only after 7 d of MPTP treatment. These observations suggest that DMT1 is possibly involved in the process of iron accumulation in SN of MPTP-treated mice, which might be responsible for the subsequent death of DA neurons.

Authors+Show Affiliations

Department of Physiology, Medical College of Qingdao University, Neuroscience Center of Shandong Province, Qingdao 266021.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14566406

Citation

Jiang, Hong, et al. "[Increased DMT1 Expression and Iron Content in MPTP-treated C57BL/6 Mice]." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 55, no. 5, 2003, pp. 571-6.
Jiang H, Qian ZM, Xie JX. [Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice]. Sheng Li Xue Bao. 2003;55(5):571-6.
Jiang, H., Qian, Z. M., & Xie, J. X. (2003). [Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice]. Sheng Li Xue Bao : [Acta Physiologica Sinica], 55(5), 571-6.
Jiang H, Qian ZM, Xie JX. [Increased DMT1 Expression and Iron Content in MPTP-treated C57BL/6 Mice]. Sheng Li Xue Bao. 2003 Oct 25;55(5):571-6. PubMed PMID: 14566406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice]. AU - Jiang,Hong, AU - Qian,Zhong-Ming, AU - Xie,Jun-Xia, PY - 2003/10/21/pubmed PY - 2004/7/23/medline PY - 2003/10/21/entrez SP - 571 EP - 6 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 55 IS - 5 N2 - Iron plays a key role in Parkinson s disease (PD). To illustrate the mechanism underlying the increase of iron in substantia nigra (SN) in PD, changes of the expression of divalent metal transporter 1 (DMT1) and iron content were examined in SN in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated mice using immunohistochemistry and histochemistry respectively. Following MPTP treatment for 3 d, elevated iron staining was found in SN. A further increase in iron content was observed after 7 d. In these lesioned animals, tyrosine hydroxylase-immunoreactive DA neurons exhibited a decrease in number and morphological changes as well. There were two isoforms of DMT1 expressed in SN of mice. After MPTP treatment, the expression of DMT1 without IRE form increased in either group, whereas DMT1 with IRE form increased only after 7 d of MPTP treatment. These observations suggest that DMT1 is possibly involved in the process of iron accumulation in SN of MPTP-treated mice, which might be responsible for the subsequent death of DA neurons. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/14566406/[Increased_DMT1_expression_and_iron_content_in_MPTP_treated_C57BL/6_mice]_ L2 - http://www.actaps.com.cn/paper/200305/pdf/13.pdf DB - PRIME DP - Unbound Medicine ER -