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Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1.
Arch Neurol 2003; 60(10):1385-9AN

Abstract

OBJECTIVE

To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study.

DESIGN

The CHS Cognition Study is an ancillary study of the CHS that was conducted to determine the presence of MCI and dementia in the CHS cohort.

SETTING

Multicenter population study.

PATIENTS

We examined 3608 participants in the CHS who had undergone detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI.

MAIN OUTCOME MEASURES

The prevalence of MCI was determined for the whole cohort, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center (n = 927). Mild cognitive impairment was classified as either MCI amnestic-type or MCI multiple cognitive deficits-type.

RESULTS

The overall prevalence of MCI was 19% (465 of 2470 participants); prevalence increased with age from 19% in participants younger than 75 years to 29% in those older than 85 years. The overall prevalence of MCI at the Pittsburgh center was 22% (130 of 599 participants); prevalence of the MCI amnesic-type was 6% and of the MCI multiple cognitive deficits-type was 16%.

CONCLUSIONS

Twenty-two percent of the participants aged 75 years or older had MCI. Mild cognitive impairment is a heterogeneous syndrome, where the MCI amnestic-type is less frequent than the MCI multiple cognitive deficits-type. Most of the participants with MCI had comorbid conditions that may affect their cognitive functions.

Authors+Show Affiliations

Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pa, USA. lopezol@msx.upmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14568808

Citation

Lopez, Oscar L., et al. "Prevalence and Classification of Mild Cognitive Impairment in the Cardiovascular Health Study Cognition Study: Part 1." Archives of Neurology, vol. 60, no. 10, 2003, pp. 1385-9.
Lopez OL, Jagust WJ, DeKosky ST, et al. Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1. Arch Neurol. 2003;60(10):1385-9.
Lopez, O. L., Jagust, W. J., DeKosky, S. T., Becker, J. T., Fitzpatrick, A., Dulberg, C., ... Kuller, L. H. (2003). Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1. Archives of Neurology, 60(10), pp. 1385-9.
Lopez OL, et al. Prevalence and Classification of Mild Cognitive Impairment in the Cardiovascular Health Study Cognition Study: Part 1. Arch Neurol. 2003;60(10):1385-9. PubMed PMID: 14568808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1. AU - Lopez,Oscar L, AU - Jagust,William J, AU - DeKosky,Steven T, AU - Becker,James T, AU - Fitzpatrick,Annette, AU - Dulberg,Corinne, AU - Breitner,John, AU - Lyketsos,Constantine, AU - Jones,Beverly, AU - Kawas,Claudia, AU - Carlson,Michelle, AU - Kuller,Lewis H, PY - 2003/10/22/pubmed PY - 2003/12/3/medline PY - 2003/10/22/entrez SP - 1385 EP - 9 JF - Archives of neurology JO - Arch. Neurol. VL - 60 IS - 10 N2 - OBJECTIVE: To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study. DESIGN: The CHS Cognition Study is an ancillary study of the CHS that was conducted to determine the presence of MCI and dementia in the CHS cohort. SETTING: Multicenter population study. PATIENTS: We examined 3608 participants in the CHS who had undergone detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI. MAIN OUTCOME MEASURES: The prevalence of MCI was determined for the whole cohort, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center (n = 927). Mild cognitive impairment was classified as either MCI amnestic-type or MCI multiple cognitive deficits-type. RESULTS: The overall prevalence of MCI was 19% (465 of 2470 participants); prevalence increased with age from 19% in participants younger than 75 years to 29% in those older than 85 years. The overall prevalence of MCI at the Pittsburgh center was 22% (130 of 599 participants); prevalence of the MCI amnesic-type was 6% and of the MCI multiple cognitive deficits-type was 16%. CONCLUSIONS: Twenty-two percent of the participants aged 75 years or older had MCI. Mild cognitive impairment is a heterogeneous syndrome, where the MCI amnestic-type is less frequent than the MCI multiple cognitive deficits-type. Most of the participants with MCI had comorbid conditions that may affect their cognitive functions. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/14568808/Prevalence_and_classification_of_mild_cognitive_impairment_in_the_Cardiovascular_Health_Study_Cognition_Study:_part_1_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/60/pg/1385 DB - PRIME DP - Unbound Medicine ER -