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Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin.
Obes Res. 2003 Oct; 11(10):1200-6.OR

Abstract

OBJECTIVE

To assess the interaction between apolipoprotein (apo) E polymorphism, alcohol consumption, and BMI on insulin, lipid, and lipoprotein levels in men.

RESEARCH METHODS AND PROCEDURES

Cross-sectional study of 266 healthy men without hypolipidemic or antidiabetic drug treatment. BMI, apo E polymorphisms, insulin, and lipid and lipoprotein levels were assessed. Alcohol consumption was assessed by questionnaire. epsilon2/epsilon4 carriers were excluded from the analysis.

RESULTS

On bivariate analysis, epsilon2 carriers had lower levels of total and low-density lipoprotein cholesterol and higher levels of apo E and lipoparticle B:E than epsilon3 carriers, the opposite being found for epsilon4 carriers compared with epsilon3 carriers; epsilon4 carriers also had significantly higher insulin levels. On multivariate analysis, significant interactions (p < 0.04) between apo E alleles and increased BMI were found for total and low-density lipoprotein cholesterol and insulin levels, the increase in those parameters with BMI being stronger among epsilon4 carriers than among epsilon3 or epsilon2 carriers. Significant interactions (p < 0.02) between apo E alleles and alcohol consumption were also found for apo B levels, which increased in epsilon2 carriers but remained relatively stable in epsilon3 and tended to decrease in epsilon4 carriers.

DISCUSSION

These data suggest that effects of apo E alleles on lipids and insulin levels are partly dependent on environmental variables such as BMI and alcohol intake. These findings highlight the importance of gene x environment interactions on the deleterious effect of obesity on cardiovascular risk factors.

Authors+Show Affiliations

Institut National de la Santé et de la Recherche Médicale U558, Department of Epidemiology, 37 Allées Jules Guesde, Toulouse, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14569045

Citation

Marques-Vidal, Pedro, et al. "Obesity and Alcohol Modulate the Effect of Apolipoprotein E Polymorphism On Lipids and Insulin." Obesity Research, vol. 11, no. 10, 2003, pp. 1200-6.
Marques-Vidal P, Bongard V, Ruidavets JB, et al. Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin. Obes Res. 2003;11(10):1200-6.
Marques-Vidal, P., Bongard, V., Ruidavets, J. B., Fauvel, J., Hanaire-Broutin, H., Perret, B., & Ferrières, J. (2003). Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin. Obesity Research, 11(10), 1200-6.
Marques-Vidal P, et al. Obesity and Alcohol Modulate the Effect of Apolipoprotein E Polymorphism On Lipids and Insulin. Obes Res. 2003;11(10):1200-6. PubMed PMID: 14569045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin. AU - Marques-Vidal,Pedro, AU - Bongard,Vanina, AU - Ruidavets,Jean-Bernard, AU - Fauvel,Josette, AU - Hanaire-Broutin,Hélène, AU - Perret,Bertrand, AU - Ferrières,Jean, PY - 2003/10/22/pubmed PY - 2004/7/21/medline PY - 2003/10/22/entrez SP - 1200 EP - 6 JF - Obesity research JO - Obes Res VL - 11 IS - 10 N2 - OBJECTIVE: To assess the interaction between apolipoprotein (apo) E polymorphism, alcohol consumption, and BMI on insulin, lipid, and lipoprotein levels in men. RESEARCH METHODS AND PROCEDURES: Cross-sectional study of 266 healthy men without hypolipidemic or antidiabetic drug treatment. BMI, apo E polymorphisms, insulin, and lipid and lipoprotein levels were assessed. Alcohol consumption was assessed by questionnaire. epsilon2/epsilon4 carriers were excluded from the analysis. RESULTS: On bivariate analysis, epsilon2 carriers had lower levels of total and low-density lipoprotein cholesterol and higher levels of apo E and lipoparticle B:E than epsilon3 carriers, the opposite being found for epsilon4 carriers compared with epsilon3 carriers; epsilon4 carriers also had significantly higher insulin levels. On multivariate analysis, significant interactions (p < 0.04) between apo E alleles and increased BMI were found for total and low-density lipoprotein cholesterol and insulin levels, the increase in those parameters with BMI being stronger among epsilon4 carriers than among epsilon3 or epsilon2 carriers. Significant interactions (p < 0.02) between apo E alleles and alcohol consumption were also found for apo B levels, which increased in epsilon2 carriers but remained relatively stable in epsilon3 and tended to decrease in epsilon4 carriers. DISCUSSION: These data suggest that effects of apo E alleles on lipids and insulin levels are partly dependent on environmental variables such as BMI and alcohol intake. These findings highlight the importance of gene x environment interactions on the deleterious effect of obesity on cardiovascular risk factors. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/14569045/Obesity_and_alcohol_modulate_the_effect_of_apolipoprotein_E_polymorphism_on_lipids_and_insulin_ L2 - https://doi.org/10.1038/oby.2003.165 DB - PRIME DP - Unbound Medicine ER -