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Effect of family history of type 2 diabetes on white blood cell count in adult women.
Obes Res. 2003 Oct; 11(10):1232-7.OR

Abstract

OBJECTIVE

To evaluate the effect of a first-degree family history of type 2 diabetes on white blood cell (WBC) count, a risk factor for atherosclerotic vascular disease, in glucose-tolerant adult women.

RESEARCH METHODS AND PROCEDURES

WBC count was measured in 174 normal weight, overweight, and obese female offspring of type 2 diabetic patients (FH(+)) and 174 age- and BMI-matched female controls with no family history of type 2 diabetes (FH(-)). Other measurements included fat mass (FM), measured by body impedance analysis; central fat accumulation, evaluated by waist circumference; insulin resistance, estimated by homeostatic model assessment for insulin resistance (HOMA(IR)); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin, and lipids.

RESULTS

WBC count, waist circumference, systolic blood pressure, and fasting levels of glucose, insulin, and triglycerides were significantly higher in FH(+) than in FH(-) subjects. In FH(+) individuals, WBC count was positively associated with BMI, FM, waist circumference, HOMA(IR), and triglyceride and insulin concentrations, and negatively correlated with age and high-density lipoprotein-cholesterol. In FH(-) subjects, WBC count was directly associated with BMI, FM, waist circumference, and triglyceride and insulin concentrations, and inversely correlated with age and high-density lipoprotein-cholesterol. After multivariate analyses, WBC count maintained a significant association with age, systolic blood pressure, and HOMA(IR) in FH(+) subjects and with age, BMI, FM, and triglycerides in FH(-) individuals.

DISCUSSION

This study indicates that WBC count is increased in adult women with genetic predisposition to type 2 diabetes, and its main correlates are insulin resistance in FH(+) and adiposity in FH(-) individuals.

Authors+Show Affiliations

Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14569049

Citation

Pannacciulli, Nicola, et al. "Effect of Family History of Type 2 Diabetes On White Blood Cell Count in Adult Women." Obesity Research, vol. 11, no. 10, 2003, pp. 1232-7.
Pannacciulli N, Giorgino F, Martina RA, et al. Effect of family history of type 2 diabetes on white blood cell count in adult women. Obes Res. 2003;11(10):1232-7.
Pannacciulli, N., Giorgino, F., Martina, R. A., Resta, O., Giorgino, R., & De Pergola, G. (2003). Effect of family history of type 2 diabetes on white blood cell count in adult women. Obesity Research, 11(10), 1232-7.
Pannacciulli N, et al. Effect of Family History of Type 2 Diabetes On White Blood Cell Count in Adult Women. Obes Res. 2003;11(10):1232-7. PubMed PMID: 14569049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of family history of type 2 diabetes on white blood cell count in adult women. AU - Pannacciulli,Nicola, AU - Giorgino,Francesco, AU - Martina,Raffaele A, AU - Resta,Onofrio, AU - Giorgino,Riccardo, AU - De Pergola,Giovanni, PY - 2003/10/22/pubmed PY - 2004/7/21/medline PY - 2003/10/22/entrez SP - 1232 EP - 7 JF - Obesity research JO - Obes Res VL - 11 IS - 10 N2 - OBJECTIVE: To evaluate the effect of a first-degree family history of type 2 diabetes on white blood cell (WBC) count, a risk factor for atherosclerotic vascular disease, in glucose-tolerant adult women. RESEARCH METHODS AND PROCEDURES: WBC count was measured in 174 normal weight, overweight, and obese female offspring of type 2 diabetic patients (FH(+)) and 174 age- and BMI-matched female controls with no family history of type 2 diabetes (FH(-)). Other measurements included fat mass (FM), measured by body impedance analysis; central fat accumulation, evaluated by waist circumference; insulin resistance, estimated by homeostatic model assessment for insulin resistance (HOMA(IR)); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin, and lipids. RESULTS: WBC count, waist circumference, systolic blood pressure, and fasting levels of glucose, insulin, and triglycerides were significantly higher in FH(+) than in FH(-) subjects. In FH(+) individuals, WBC count was positively associated with BMI, FM, waist circumference, HOMA(IR), and triglyceride and insulin concentrations, and negatively correlated with age and high-density lipoprotein-cholesterol. In FH(-) subjects, WBC count was directly associated with BMI, FM, waist circumference, and triglyceride and insulin concentrations, and inversely correlated with age and high-density lipoprotein-cholesterol. After multivariate analyses, WBC count maintained a significant association with age, systolic blood pressure, and HOMA(IR) in FH(+) subjects and with age, BMI, FM, and triglycerides in FH(-) individuals. DISCUSSION: This study indicates that WBC count is increased in adult women with genetic predisposition to type 2 diabetes, and its main correlates are insulin resistance in FH(+) and adiposity in FH(-) individuals. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/14569049/Effect_of_family_history_of_type_2_diabetes_on_white_blood_cell_count_in_adult_women_ L2 - https://doi.org/10.1038/oby.2003.169 DB - PRIME DP - Unbound Medicine ER -