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Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients.
Eur J Nutr. 2003 Oct; 42(5):235-42.EJ

Abstract

BACKGROUND

Recently, insoluble fibre from carob pulp has been found to affect blood lipids in animals in a similar manner as soluble dietary fibre.

AIM OF THE STUDY

To investigate whether a carob pulp preparation containing high amounts of insoluble fibre has a beneficial effect on serum cholesterol in humans.

METHODS

Volunteers (n = 58) with hypercholesterolemia were recruited to participate in a randomised, double- blind, placebo-controlled and parallel arm clinical study with a 6 week intervention phase. All participants consumed daily both, bread (two servings) and a fruitbar (one serving) either with (n = 29) or without (n = 29) a total amount of 15 g/d of a carob pulp preparation (carob fibre). Serum concentrations of total, LDL and HDL cholesterol and triglycerides were assessed at baseline and after week 4 and 6.

RESULTS

The consumption of carob fibre reduced LDL cholesterol by 10.5 +/- 2.2% (p = 0.010). The LDL:HDL cholesterol ratio was marginally decreased by 7.9 +/- 2.2 % in the carob fibre group compared to the placebo group (p = 0.058). Carob fibre consumption also lowered triglycerides in females by 11.3 +/- 4.5% (p = 0.030). Lipid lowering effects were more pronounced in females than in males.

CONCLUSION

Daily consumption of food products enriched with carob fibre shows beneficial effects on human blood lipid profile and may be effective in prevention and treatment of hypercholesterolemia.

Authors+Show Affiliations

Institute for Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558, Bergholz-Rehbrücke, Germany. zunft@mail.dife.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14569404

Citation

Zunft, H J F., et al. "Carob Pulp Preparation Rich in Insoluble Fibre Lowers Total and LDL Cholesterol in Hypercholesterolemic Patients." European Journal of Nutrition, vol. 42, no. 5, 2003, pp. 235-42.
Zunft HJ, Lüder W, Harde A, et al. Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients. Eur J Nutr. 2003;42(5):235-42.
Zunft, H. J., Lüder, W., Harde, A., Haber, B., Graubaum, H. J., Koebnick, C., & Grünwald, J. (2003). Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients. European Journal of Nutrition, 42(5), 235-42.
Zunft HJ, et al. Carob Pulp Preparation Rich in Insoluble Fibre Lowers Total and LDL Cholesterol in Hypercholesterolemic Patients. Eur J Nutr. 2003;42(5):235-42. PubMed PMID: 14569404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients. AU - Zunft,H J F, AU - Lüder,W, AU - Harde,A, AU - Haber,B, AU - Graubaum,H J, AU - Koebnick,C, AU - Grünwald,J, PY - 2002/09/19/received PY - 2003/06/12/accepted PY - 2003/10/22/pubmed PY - 2004/3/10/medline PY - 2003/10/22/entrez SP - 235 EP - 42 JF - European journal of nutrition JO - Eur J Nutr VL - 42 IS - 5 N2 - BACKGROUND: Recently, insoluble fibre from carob pulp has been found to affect blood lipids in animals in a similar manner as soluble dietary fibre. AIM OF THE STUDY: To investigate whether a carob pulp preparation containing high amounts of insoluble fibre has a beneficial effect on serum cholesterol in humans. METHODS: Volunteers (n = 58) with hypercholesterolemia were recruited to participate in a randomised, double- blind, placebo-controlled and parallel arm clinical study with a 6 week intervention phase. All participants consumed daily both, bread (two servings) and a fruitbar (one serving) either with (n = 29) or without (n = 29) a total amount of 15 g/d of a carob pulp preparation (carob fibre). Serum concentrations of total, LDL and HDL cholesterol and triglycerides were assessed at baseline and after week 4 and 6. RESULTS: The consumption of carob fibre reduced LDL cholesterol by 10.5 +/- 2.2% (p = 0.010). The LDL:HDL cholesterol ratio was marginally decreased by 7.9 +/- 2.2 % in the carob fibre group compared to the placebo group (p = 0.058). Carob fibre consumption also lowered triglycerides in females by 11.3 +/- 4.5% (p = 0.030). Lipid lowering effects were more pronounced in females than in males. CONCLUSION: Daily consumption of food products enriched with carob fibre shows beneficial effects on human blood lipid profile and may be effective in prevention and treatment of hypercholesterolemia. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/14569404/Carob_pulp_preparation_rich_in_insoluble_fibre_lowers_total_and_LDL_cholesterol_in_hypercholesterolemic_patients_ L2 - https://dx.doi.org/10.1007/s00394-003-0438-y DB - PRIME DP - Unbound Medicine ER -