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Expression of telomerase hTERT in human non-small cell lung cancer and its correlation with c-myc gene.
Chin Med J (Engl). 2003 Oct; 116(10):1467-70.CM

Abstract

OBJECTIVE

To investigate the expression of human telomerase catalytic subunit, hTERT, in human non-small cell lung cancer (NSCLC) and its correlations to c-myc gene.

METHODS

hTERT and c-myc mRNA expressions were detected by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Statistical correlation analysis was made to estimate whether there was interrelation between them.

RESULTS

Positive rate of hTERT expression in 51 surgically resected lung cancer specimens was 86.3%, significantly higher than that in adjacent non-neoplastic lung tissues and benign lesions, which were 14.3% and 27.3% respectively. No statistical significance was observed between the frequency of hTERT expression and histologic types, degree of differentiation, TNM stages, tumor size or lymph nodes metastases. Correlation analysis revealed that the expression of c-myc gene was significantly related to that of hTERT (correlation coefficient, r = 0.633, P < 0.001).

CONCLUSIONS

hTERT may be a useful tumor marker in diagnosing lung cancer. Significant correlation between the expression of hTERT and c-myc mRNA indicates that the activation and up-regulation of hTERT might be conferred by over-expression of c-myc gene.

Authors+Show Affiliations

Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Genny2100@yahoo.com.cnNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14570602

Citation

Geng, Zhihua, et al. "Expression of Telomerase hTERT in Human Non-small Cell Lung Cancer and Its Correlation With C-myc Gene." Chinese Medical Journal, vol. 116, no. 10, 2003, pp. 1467-70.
Geng Z, Zhang D, Liu Y. Expression of telomerase hTERT in human non-small cell lung cancer and its correlation with c-myc gene. Chin Med J (Engl). 2003;116(10):1467-70.
Geng, Z., Zhang, D., & Liu, Y. (2003). Expression of telomerase hTERT in human non-small cell lung cancer and its correlation with c-myc gene. Chinese Medical Journal, 116(10), 1467-70.
Geng Z, Zhang D, Liu Y. Expression of Telomerase hTERT in Human Non-small Cell Lung Cancer and Its Correlation With C-myc Gene. Chin Med J (Engl). 2003;116(10):1467-70. PubMed PMID: 14570602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of telomerase hTERT in human non-small cell lung cancer and its correlation with c-myc gene. AU - Geng,Zhihua, AU - Zhang,Dunhua, AU - Liu,Yinkun, PY - 2003/10/23/pubmed PY - 2004/2/28/medline PY - 2003/10/23/entrez SP - 1467 EP - 70 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 116 IS - 10 N2 - OBJECTIVE: To investigate the expression of human telomerase catalytic subunit, hTERT, in human non-small cell lung cancer (NSCLC) and its correlations to c-myc gene. METHODS: hTERT and c-myc mRNA expressions were detected by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Statistical correlation analysis was made to estimate whether there was interrelation between them. RESULTS: Positive rate of hTERT expression in 51 surgically resected lung cancer specimens was 86.3%, significantly higher than that in adjacent non-neoplastic lung tissues and benign lesions, which were 14.3% and 27.3% respectively. No statistical significance was observed between the frequency of hTERT expression and histologic types, degree of differentiation, TNM stages, tumor size or lymph nodes metastases. Correlation analysis revealed that the expression of c-myc gene was significantly related to that of hTERT (correlation coefficient, r = 0.633, P < 0.001). CONCLUSIONS: hTERT may be a useful tumor marker in diagnosing lung cancer. Significant correlation between the expression of hTERT and c-myc mRNA indicates that the activation and up-regulation of hTERT might be conferred by over-expression of c-myc gene. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/14570602/Expression_of_telomerase_hTERT_in_human_non_small_cell_lung_cancer_and_its_correlation_with_c_myc_gene_ L2 - http://www.diseaseinfosearch.org/result/4334 DB - PRIME DP - Unbound Medicine ER -