Tags

Type your tag names separated by a space and hit enter

Intestinal permeability is increased in patients with advanced cirrhosis.
Hepatogastroenterology. 2003 Sep-Oct; 50(53):1482-6.H

Abstract

BACKGROUND/AIMS

The dysfunction of the intestinal barrier is a factor that has been related to bacterial translocation from lumen to extra-intestinal sites and consequently to the development of spontaneous bacterial peritonitis. The aim of this study was to investigate if the alterations of the intestinal barrier in cirrhosis are related with the degree of liver failure and associated with other clinical complications.

METHODOLOGY

Intestinal permeability was assessed by means of the lactulose/mannitol test in 79 cirrhotic and 25 controls subjects. They received 10 g of lactulose and 5 g of mannitol. Lactulose and mannitol were measured in a five-hour urinary volume.

RESULTS

Lactulose/mannitol ratio was significantly higher in cirrhotic patients than in controls (p = 0.03). This was more evident in end-stage cirrhosis. Patients with ascites, or encephalopathy showed a statistically significant increase in lactulose/mannitol ratio when compared to patients without these complications.

CONCLUSIONS

The increased intestinal permeability is related to the progression of the liver disease and is more relevant with overt clinical complications. This is due to an increased absorption of lactulose. However, as liver disease progresses, mannitol absorption is progressively reduced, probably due to a reduced surface of absorption, and these events are more relevant in patients with overt clinical complications.

Authors+Show Affiliations

Liver Unit, Department of Internal Medicine, University General Hospital of Alicante C/Pintor Baeza s/n, Alicante 03010, Spain. pascual_son@gva.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14571769

Citation

Pascual, Sonia, et al. "Intestinal Permeability Is Increased in Patients With Advanced Cirrhosis." Hepato-gastroenterology, vol. 50, no. 53, 2003, pp. 1482-6.
Pascual S, Such J, Esteban A, et al. Intestinal permeability is increased in patients with advanced cirrhosis. Hepatogastroenterology. 2003;50(53):1482-6.
Pascual, S., Such, J., Esteban, A., Zapater, P., Casellas, J. A., Aparicio, J. R., Girona, E., Gutiérrez, A., Carnices, F., Palazón, J. M., Sola-Vera, J., & Pérez-Mateo, M. (2003). Intestinal permeability is increased in patients with advanced cirrhosis. Hepato-gastroenterology, 50(53), 1482-6.
Pascual S, et al. Intestinal Permeability Is Increased in Patients With Advanced Cirrhosis. Hepatogastroenterology. 2003 Sep-Oct;50(53):1482-6. PubMed PMID: 14571769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal permeability is increased in patients with advanced cirrhosis. AU - Pascual,Sonia, AU - Such,José, AU - Esteban,Angel, AU - Zapater,Pedro, AU - Casellas,Juan A, AU - Aparicio,José R, AU - Girona,Eva, AU - Gutiérrez,Ana, AU - Carnices,Fernando, AU - Palazón,Jose M, AU - Sola-Vera,Javier, AU - Pérez-Mateo,Miguel, PY - 2003/10/24/pubmed PY - 2004/2/26/medline PY - 2003/10/24/entrez SP - 1482 EP - 6 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 50 IS - 53 N2 - BACKGROUND/AIMS: The dysfunction of the intestinal barrier is a factor that has been related to bacterial translocation from lumen to extra-intestinal sites and consequently to the development of spontaneous bacterial peritonitis. The aim of this study was to investigate if the alterations of the intestinal barrier in cirrhosis are related with the degree of liver failure and associated with other clinical complications. METHODOLOGY: Intestinal permeability was assessed by means of the lactulose/mannitol test in 79 cirrhotic and 25 controls subjects. They received 10 g of lactulose and 5 g of mannitol. Lactulose and mannitol were measured in a five-hour urinary volume. RESULTS: Lactulose/mannitol ratio was significantly higher in cirrhotic patients than in controls (p = 0.03). This was more evident in end-stage cirrhosis. Patients with ascites, or encephalopathy showed a statistically significant increase in lactulose/mannitol ratio when compared to patients without these complications. CONCLUSIONS: The increased intestinal permeability is related to the progression of the liver disease and is more relevant with overt clinical complications. This is due to an increased absorption of lactulose. However, as liver disease progresses, mannitol absorption is progressively reduced, probably due to a reduced surface of absorption, and these events are more relevant in patients with overt clinical complications. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/14571769/Intestinal_permeability_is_increased_in_patients_with_advanced_cirrhosis_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -