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The importance of parity to major maternal morbidity in the eclamptic mother with HELLP syndrome.
Hypertens Pregnancy. 2003; 22(3):287-94.HP

Abstract

OBJECTIVE

To determine if the rate of major morbidity from severe preeclampsia with/without hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome differs by parity.

METHODS

Retrospective investigation of 970 gravidas with severe preeclampsia with and without HELLP syndrome analyzed according to parity.

RESULTS

Altogether 609 (63%) patients were nulliparous and 361 (37%) parous. Between groups there was no significant difference in the incidence of overall major morbidity (21% vs. 19%, p=0.467), or specific morbidities including hematologic/coagulopathic (13.6% vs. 11.9%, p=0.442), cardiopulmonary (8.9% vs. 7.2%, p=0.362), CNS/visual (1.8% vs. 2.8%, p=0.319), or hepatorenal (0.8% vs. 2.2%, p=0.068). Although eclampsia was significantly more common in nulliparous (10.2%) than in parous patients (5.5%, p=0.012), the later significantly more often demonstrated major maternal morbidity associated with eclampsia (50%) than did nulliparous patients (25%, p=0.043).

CONCLUSIONS

Unless parous patients with severe preeclampsia with or without HELLP syndrome develop eclampsia, their disease acuity does not differ significantly from their nulliparous counterparts.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, East Carolina University Brody School of Medicine, Greenville, North Carolina 27858-4354, USA. islerc@mail.ecu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14572365

Citation

Isler, Christy M., et al. "The Importance of Parity to Major Maternal Morbidity in the Eclamptic Mother With HELLP Syndrome." Hypertension in Pregnancy, vol. 22, no. 3, 2003, pp. 287-94.
Isler CM, Rinehart BK, Terrone DA, et al. The importance of parity to major maternal morbidity in the eclamptic mother with HELLP syndrome. Hypertens Pregnancy. 2003;22(3):287-94.
Isler, C. M., Rinehart, B. K., Terrone, D. A., May, W. L., Magann, E. F., & Martin, J. N. (2003). The importance of parity to major maternal morbidity in the eclamptic mother with HELLP syndrome. Hypertension in Pregnancy, 22(3), 287-94.
Isler CM, et al. The Importance of Parity to Major Maternal Morbidity in the Eclamptic Mother With HELLP Syndrome. Hypertens Pregnancy. 2003;22(3):287-94. PubMed PMID: 14572365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The importance of parity to major maternal morbidity in the eclamptic mother with HELLP syndrome. AU - Isler,Christy M, AU - Rinehart,Brian K, AU - Terrone,Dom A, AU - May,Warren L, AU - Magann,Everett F, AU - Martin,James N,Jr PY - 2003/10/24/pubmed PY - 2003/12/3/medline PY - 2003/10/24/entrez SP - 287 EP - 94 JF - Hypertension in pregnancy JO - Hypertens Pregnancy VL - 22 IS - 3 N2 - OBJECTIVE: To determine if the rate of major morbidity from severe preeclampsia with/without hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome differs by parity. METHODS: Retrospective investigation of 970 gravidas with severe preeclampsia with and without HELLP syndrome analyzed according to parity. RESULTS: Altogether 609 (63%) patients were nulliparous and 361 (37%) parous. Between groups there was no significant difference in the incidence of overall major morbidity (21% vs. 19%, p=0.467), or specific morbidities including hematologic/coagulopathic (13.6% vs. 11.9%, p=0.442), cardiopulmonary (8.9% vs. 7.2%, p=0.362), CNS/visual (1.8% vs. 2.8%, p=0.319), or hepatorenal (0.8% vs. 2.2%, p=0.068). Although eclampsia was significantly more common in nulliparous (10.2%) than in parous patients (5.5%, p=0.012), the later significantly more often demonstrated major maternal morbidity associated with eclampsia (50%) than did nulliparous patients (25%, p=0.043). CONCLUSIONS: Unless parous patients with severe preeclampsia with or without HELLP syndrome develop eclampsia, their disease acuity does not differ significantly from their nulliparous counterparts. SN - 1064-1955 UR - https://www.unboundmedicine.com/medline/citation/14572365/The_importance_of_parity_to_major_maternal_morbidity_in_the_eclamptic_mother_with_HELLP_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.1081/PRG-120024032 DB - PRIME DP - Unbound Medicine ER -