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Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study.

Abstract

Neuroanatomical substrates of age-related differences in working memory and perseverative behavior were examined in a sample of healthy adults (50-81 years old). The participants, who were screened for history of neurological, psychiatric, and medical conditions known to be linked to poor cognitive performance, underwent magnetic resonance imaging (MRI) and were administered tests of working memory and perseveration. Regional brain volumes and the volume of white matter hyperintensities (WMH) were measured on magnetic resonance images. The analyses indicate that the volume of the prefrontal cortex (PFC) and the volume of white matter hyperintensities in the prefrontal region are independently associated with age-related increases in perseverative errors on the Wisconsin Card Sorting Test (WCST). When participants taking antihypertensive medication were excluded from the analysis, both the volume of the prefrontal cortex and the frontal white matter hyperintensities (FWMH) still predicted increases in perseveration. Neither reduced volume of the prefrontal cortex nor the FWMH volume was linked to age-associated declines in working memory. The volumes of the fusiform gyrus (FG) and the temporal white matter hyperintensities (TWMH) were unrelated to cognitive performance.

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  • Authors+Show Affiliations

    ,

    Department of Psychology, Kaufman Building, Hillside Division of Long Island Jewish Medical Center, 75-59 263rd St, Glen Oaks, NY 11040, USA. fdixon@lij.edu

    Source

    Neuropsychologia 41:14 2003 pg 1929-41

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Brain
    Brain Mapping
    Cognition
    Female
    Humans
    Hypertension
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Memory, Short-Term
    Middle Aged
    Models, Biological
    Neuropsychological Tests
    Problem Solving
    Prospective Studies
    Statistics as Topic

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    14572526

    Citation

    Gunning-Dixon, Faith M., and Naftali Raz. "Neuroanatomical Correlates of Selected Executive Functions in Middle-aged and Older Adults: a Prospective MRI Study." Neuropsychologia, vol. 41, no. 14, 2003, pp. 1929-41.
    Gunning-Dixon FM, Raz N. Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study. Neuropsychologia. 2003;41(14):1929-41.
    Gunning-Dixon, F. M., & Raz, N. (2003). Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study. Neuropsychologia, 41(14), pp. 1929-41.
    Gunning-Dixon FM, Raz N. Neuroanatomical Correlates of Selected Executive Functions in Middle-aged and Older Adults: a Prospective MRI Study. Neuropsychologia. 2003;41(14):1929-41. PubMed PMID: 14572526.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study. AU - Gunning-Dixon,Faith M, AU - Raz,Naftali, PY - 2003/10/24/pubmed PY - 2004/1/13/medline PY - 2003/10/24/entrez SP - 1929 EP - 41 JF - Neuropsychologia JO - Neuropsychologia VL - 41 IS - 14 N2 - Neuroanatomical substrates of age-related differences in working memory and perseverative behavior were examined in a sample of healthy adults (50-81 years old). The participants, who were screened for history of neurological, psychiatric, and medical conditions known to be linked to poor cognitive performance, underwent magnetic resonance imaging (MRI) and were administered tests of working memory and perseveration. Regional brain volumes and the volume of white matter hyperintensities (WMH) were measured on magnetic resonance images. The analyses indicate that the volume of the prefrontal cortex (PFC) and the volume of white matter hyperintensities in the prefrontal region are independently associated with age-related increases in perseverative errors on the Wisconsin Card Sorting Test (WCST). When participants taking antihypertensive medication were excluded from the analysis, both the volume of the prefrontal cortex and the frontal white matter hyperintensities (FWMH) still predicted increases in perseveration. Neither reduced volume of the prefrontal cortex nor the FWMH volume was linked to age-associated declines in working memory. The volumes of the fusiform gyrus (FG) and the temporal white matter hyperintensities (TWMH) were unrelated to cognitive performance. SN - 0028-3932 UR - https://www.unboundmedicine.com/medline/citation/14572526/Neuroanatomical_correlates_of_selected_executive_functions_in_middle_aged_and_older_adults:_a_prospective_MRI_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028393203001295 DB - PRIME DP - Unbound Medicine ER -