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Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study.
Neuropsychologia 2003; 41(14):1929-41N

Abstract

Neuroanatomical substrates of age-related differences in working memory and perseverative behavior were examined in a sample of healthy adults (50-81 years old). The participants, who were screened for history of neurological, psychiatric, and medical conditions known to be linked to poor cognitive performance, underwent magnetic resonance imaging (MRI) and were administered tests of working memory and perseveration. Regional brain volumes and the volume of white matter hyperintensities (WMH) were measured on magnetic resonance images. The analyses indicate that the volume of the prefrontal cortex (PFC) and the volume of white matter hyperintensities in the prefrontal region are independently associated with age-related increases in perseverative errors on the Wisconsin Card Sorting Test (WCST). When participants taking antihypertensive medication were excluded from the analysis, both the volume of the prefrontal cortex and the frontal white matter hyperintensities (FWMH) still predicted increases in perseveration. Neither reduced volume of the prefrontal cortex nor the FWMH volume was linked to age-associated declines in working memory. The volumes of the fusiform gyrus (FG) and the temporal white matter hyperintensities (TWMH) were unrelated to cognitive performance.

Authors+Show Affiliations

Department of Psychology, Kaufman Building, Hillside Division of Long Island Jewish Medical Center, 75-59 263rd St, Glen Oaks, NY 11040, USA. fdixon@lij.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14572526

Citation

Gunning-Dixon, Faith M., and Naftali Raz. "Neuroanatomical Correlates of Selected Executive Functions in Middle-aged and Older Adults: a Prospective MRI Study." Neuropsychologia, vol. 41, no. 14, 2003, pp. 1929-41.
Gunning-Dixon FM, Raz N. Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study. Neuropsychologia. 2003;41(14):1929-41.
Gunning-Dixon, F. M., & Raz, N. (2003). Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study. Neuropsychologia, 41(14), pp. 1929-41.
Gunning-Dixon FM, Raz N. Neuroanatomical Correlates of Selected Executive Functions in Middle-aged and Older Adults: a Prospective MRI Study. Neuropsychologia. 2003;41(14):1929-41. PubMed PMID: 14572526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study. AU - Gunning-Dixon,Faith M, AU - Raz,Naftali, PY - 2003/10/24/pubmed PY - 2004/1/13/medline PY - 2003/10/24/entrez SP - 1929 EP - 41 JF - Neuropsychologia JO - Neuropsychologia VL - 41 IS - 14 N2 - Neuroanatomical substrates of age-related differences in working memory and perseverative behavior were examined in a sample of healthy adults (50-81 years old). The participants, who were screened for history of neurological, psychiatric, and medical conditions known to be linked to poor cognitive performance, underwent magnetic resonance imaging (MRI) and were administered tests of working memory and perseveration. Regional brain volumes and the volume of white matter hyperintensities (WMH) were measured on magnetic resonance images. The analyses indicate that the volume of the prefrontal cortex (PFC) and the volume of white matter hyperintensities in the prefrontal region are independently associated with age-related increases in perseverative errors on the Wisconsin Card Sorting Test (WCST). When participants taking antihypertensive medication were excluded from the analysis, both the volume of the prefrontal cortex and the frontal white matter hyperintensities (FWMH) still predicted increases in perseveration. Neither reduced volume of the prefrontal cortex nor the FWMH volume was linked to age-associated declines in working memory. The volumes of the fusiform gyrus (FG) and the temporal white matter hyperintensities (TWMH) were unrelated to cognitive performance. SN - 0028-3932 UR - https://www.unboundmedicine.com/medline/citation/14572526/Neuroanatomical_correlates_of_selected_executive_functions_in_middle_aged_and_older_adults:_a_prospective_MRI_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028393203001295 DB - PRIME DP - Unbound Medicine ER -