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Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat.
Avian Dis 2003; 47(3 Suppl):1135-40AD

Abstract

The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus.

Authors+Show Affiliations

Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N.E., Atlanta, GA 30333, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14575129

Citation

Lu, X H., et al. "Pathogenesis of and Immunity to a New Influenza a (H5N1) Virus Isolated From Duck Meat." Avian Diseases, vol. 47, no. 3 Suppl, 2003, pp. 1135-40.
Lu XH, Cho D, Hall H, et al. Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat. Avian Dis. 2003;47(3 Suppl):1135-40.
Lu, X. H., Cho, D., Hall, H., Rowe, T., Mo, I. P., Sung, H. W., ... Katz, J. M. (2003). Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat. Avian Diseases, 47(3 Suppl), pp. 1135-40.
Lu XH, et al. Pathogenesis of and Immunity to a New Influenza a (H5N1) Virus Isolated From Duck Meat. Avian Dis. 2003;47(3 Suppl):1135-40. PubMed PMID: 14575129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat. AU - Lu,X H, AU - Cho,D, AU - Hall,H, AU - Rowe,T, AU - Mo,I P, AU - Sung,H W, AU - Kim,W J, AU - Kang,C, AU - Cox,N, AU - Klimov,A, AU - Katz,J M, PY - 2003/10/25/pubmed PY - 2003/12/12/medline PY - 2003/10/25/entrez SP - 1135 EP - 40 JF - Avian diseases JO - Avian Dis. VL - 47 IS - 3 Suppl N2 - The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus. SN - 0005-2086 UR - https://www.unboundmedicine.com/medline/citation/14575129/Pathogenesis_of_and_immunity_to_a_new_influenza_A__H5N1__virus_isolated_from_duck_meat_ L2 - https://doi.org/10.1637/0005-2086-47.s3.1135 DB - PRIME DP - Unbound Medicine ER -