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[Expression of lung resistance protein and multidrug resistance protein genes in bone marrow cells of acute leukemia patients and its clinical significance].
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003 Oct; 11(5):472-5.ZS

Abstract

To study the expression of lung resistance protein (LRP) and multidrug resistance protein (MRP) genes in bone marrow cells in patients with acute leukemia and its clinical significance, expression of LRP and MRP mRNA in bone marrow cells from 47 cases of acute leukemia, including 10 refractory or relapsed cases, and 7 normal individuals were determined by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). The result s showed that expression of LRP gene was negative in normal individuals. LRP mRNA level in newly treated cases of acute myelocytic leukemia and refractory or relapsed cases was significantly higher than that in normal individuals, increased LRP mRNA level has correlation with lower sensitivity to initial chemotherapy and was associated with reduced overall survival rate. Complete remission (CR) rate in LRP positive patients was lower than that in negative cases. The level of LRP expression was correlated with that of MRP mRNA. In conclusion, the expression of LRP mRNA can predict the treatment outcome and prognosis for acute myelocytic leukemia, prognosis was even worse in LRP and MRP linked expression cases, therefore, LRP was an important resistant factor, determination of LRP and MRP expression can help us to evaluate the prognosis and choose chemotherapy program.

Authors+Show Affiliations

Institute of Hematology, Jinan University Medical College, Guangzhou 510630, China. chizuohua@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

14575539

Citation

Chi, Zuo-Hua, et al. "[Expression of Lung Resistance Protein and Multidrug Resistance Protein Genes in Bone Marrow Cells of Acute Leukemia Patients and Its Clinical Significance]." Zhongguo Shi Yan Xue Ye Xue Za Zhi, vol. 11, no. 5, 2003, pp. 472-5.
Chi ZH, Liu Z, Sun C, et al. [Expression of lung resistance protein and multidrug resistance protein genes in bone marrow cells of acute leukemia patients and its clinical significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003;11(5):472-5.
Chi, Z. H., Liu, Z., Sun, C., Zhao, H. G., & Liu, J. L. (2003). [Expression of lung resistance protein and multidrug resistance protein genes in bone marrow cells of acute leukemia patients and its clinical significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 11(5), 472-5.
Chi ZH, et al. [Expression of Lung Resistance Protein and Multidrug Resistance Protein Genes in Bone Marrow Cells of Acute Leukemia Patients and Its Clinical Significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003;11(5):472-5. PubMed PMID: 14575539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of lung resistance protein and multidrug resistance protein genes in bone marrow cells of acute leukemia patients and its clinical significance]. AU - Chi,Zuo-Hua, AU - Liu,Zhen, AU - Sun,Chen, AU - Zhao,Hong-Guo, AU - Liu,Jin-Lan, PY - 2003/10/25/pubmed PY - 2004/4/16/medline PY - 2003/10/25/entrez SP - 472 EP - 5 JF - Zhongguo shi yan xue ye xue za zhi JO - Zhongguo Shi Yan Xue Ye Xue Za Zhi VL - 11 IS - 5 N2 - To study the expression of lung resistance protein (LRP) and multidrug resistance protein (MRP) genes in bone marrow cells in patients with acute leukemia and its clinical significance, expression of LRP and MRP mRNA in bone marrow cells from 47 cases of acute leukemia, including 10 refractory or relapsed cases, and 7 normal individuals were determined by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). The result s showed that expression of LRP gene was negative in normal individuals. LRP mRNA level in newly treated cases of acute myelocytic leukemia and refractory or relapsed cases was significantly higher than that in normal individuals, increased LRP mRNA level has correlation with lower sensitivity to initial chemotherapy and was associated with reduced overall survival rate. Complete remission (CR) rate in LRP positive patients was lower than that in negative cases. The level of LRP expression was correlated with that of MRP mRNA. In conclusion, the expression of LRP mRNA can predict the treatment outcome and prognosis for acute myelocytic leukemia, prognosis was even worse in LRP and MRP linked expression cases, therefore, LRP was an important resistant factor, determination of LRP and MRP expression can help us to evaluate the prognosis and choose chemotherapy program. SN - 1009-2137 UR - https://www.unboundmedicine.com/medline/citation/14575539/[Expression_of_lung_resistance_protein_and_multidrug_resistance_protein_genes_in_bone_marrow_cells_of_acute_leukemia_patients_and_its_clinical_significance]_ L2 - https://medlineplus.gov/acutemyeloidleukemia.html DB - PRIME DP - Unbound Medicine ER -