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Asbestosis and idiopathic pulmonary fibrosis: comparison of thin-section CT features.
Radiology. 2003 Dec; 229(3):731-6.R

Abstract

PURPOSE

To identify differences, if any, in thin-section computed tomographic (CT) features between asbestosis and idiopathic pulmonary fibrosis (IPF) and to test the findings in a subset of histopathologically proved cases of usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP).

MATERIALS AND METHODS

Consecutive patients with a diagnosis of IPF (n = 212) or asbestosis (n = 74) were included. The relationships derived from the initial comparison were tested in a separate group of biopsy-proved UIP (n = 30) and NSIP (n = 23) cases. Two observers independently scored thin-section CT images for extent, distribution, and coarseness of fibrosis; proportion of ground-glass opacification; severity of traction bronchiectasis; and extent of emphysema.

RESULTS

After controlling for extent of fibrosis, patients with asbestosis had coarser fibrosis than those with IPF (odds ratio, 1.52; 95% CI: 1.25, 1.84; P <.001). Compared with the biopsy-proved cases, the asbestosis cases involved coarser fibrosis (after controlling for disease extent) than the NSIP cases (odds ratio, 2.48; 95% CI: 1.49, 4.11; P <.001) but fibrosis similar to that in the UIP cases. A basal and subpleural distribution of disease was usual in all subgroups but significantly more prevalent (P, <.01 to.001) with asbestosis than with UIP or NSIP.

CONCLUSION

The thin-section CT pattern of asbestosis closely resembles that of biopsy-proved UIP and differs markedly from that of biopsy-proved NSIP.

Authors+Show Affiliations

Department of Radiology, Hammersmith Hospital, London, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14576443

Citation

Copley, Susan J., et al. "Asbestosis and Idiopathic Pulmonary Fibrosis: Comparison of Thin-section CT Features." Radiology, vol. 229, no. 3, 2003, pp. 731-6.
Copley SJ, Wells AU, Sivakumaran P, et al. Asbestosis and idiopathic pulmonary fibrosis: comparison of thin-section CT features. Radiology. 2003;229(3):731-6.
Copley, S. J., Wells, A. U., Sivakumaran, P., Rubens, M. B., Lee, Y. C., Desai, S. R., MacDonald, S. L., Thompson, R. I., Colby, T. V., Nicholson, A. G., du Bois, R. M., Musk, A. W., & Hansell, D. M. (2003). Asbestosis and idiopathic pulmonary fibrosis: comparison of thin-section CT features. Radiology, 229(3), 731-6.
Copley SJ, et al. Asbestosis and Idiopathic Pulmonary Fibrosis: Comparison of Thin-section CT Features. Radiology. 2003;229(3):731-6. PubMed PMID: 14576443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asbestosis and idiopathic pulmonary fibrosis: comparison of thin-section CT features. AU - Copley,Susan J, AU - Wells,Athol U, AU - Sivakumaran,Pathanamathan, AU - Rubens,Michael B, AU - Lee,Y C Gary, AU - Desai,Sujal R, AU - MacDonald,Sharyn L S, AU - Thompson,Richard I, AU - Colby,Thomas V, AU - Nicholson,Andrew G, AU - du Bois,Roland M, AU - Musk,A William, AU - Hansell,David M, Y1 - 2003/10/23/ PY - 2003/10/25/pubmed PY - 2004/1/13/medline PY - 2003/10/25/entrez SP - 731 EP - 6 JF - Radiology JO - Radiology VL - 229 IS - 3 N2 - PURPOSE: To identify differences, if any, in thin-section computed tomographic (CT) features between asbestosis and idiopathic pulmonary fibrosis (IPF) and to test the findings in a subset of histopathologically proved cases of usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). MATERIALS AND METHODS: Consecutive patients with a diagnosis of IPF (n = 212) or asbestosis (n = 74) were included. The relationships derived from the initial comparison were tested in a separate group of biopsy-proved UIP (n = 30) and NSIP (n = 23) cases. Two observers independently scored thin-section CT images for extent, distribution, and coarseness of fibrosis; proportion of ground-glass opacification; severity of traction bronchiectasis; and extent of emphysema. RESULTS: After controlling for extent of fibrosis, patients with asbestosis had coarser fibrosis than those with IPF (odds ratio, 1.52; 95% CI: 1.25, 1.84; P <.001). Compared with the biopsy-proved cases, the asbestosis cases involved coarser fibrosis (after controlling for disease extent) than the NSIP cases (odds ratio, 2.48; 95% CI: 1.49, 4.11; P <.001) but fibrosis similar to that in the UIP cases. A basal and subpleural distribution of disease was usual in all subgroups but significantly more prevalent (P, <.01 to.001) with asbestosis than with UIP or NSIP. CONCLUSION: The thin-section CT pattern of asbestosis closely resembles that of biopsy-proved UIP and differs markedly from that of biopsy-proved NSIP. SN - 0033-8419 UR - https://www.unboundmedicine.com/medline/citation/14576443/Asbestosis_and_idiopathic_pulmonary_fibrosis:_comparison_of_thin_section_CT_features_ L2 - https://pubs.rsna.org/doi/10.1148/radiol.2293020668?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -