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Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroup.

Abstract

Evidence suggests hormonal factors may be more strongly associated with estrogen receptor+progesterone receptor+ (ER+PR+) than ER-PR- breast cancer risk. This study evaluated risk factors according to ERPR tumor status among pre- and postmenopausal women participating in two recent population-based case-control studies. Breast cancer cases, ages 25-74 years, and diagnosed 1995-1998 were sampled from the Ontario Cancer Registry. Controls were a random sample of women identified using the Ontario Ministry of Finance rolls and were frequency-matched to cases within 5-year age groups. Epidemiological data were collected from breast cancer cases and controls using two self-administered questionnaires. ERPR data were obtained for 87% of the breast cancer cases (3,276 of 3,748). Multivariate polytomous logistic regression was used to obtain odds ratios estimates and 95% confidence intervals. The following significant differences were observed in the risk factor profiles for ER+PR+ and ER-PR- breast cancer: among premenopausal women, late age at menarche was only associated with a reduction in ER+PR+ breast cancer risk; obesity was associated with an increased ER-PR- and decreased ER+PR+ cancer risk; and the association between alcohol intake and breast cancer risk was heterogeneous across ERPR subgroups, although the direction varied across the levels of alcohol intake. Among postmenopausal women, there were no statistically significant differences observed in the risk factor profiles for ER+PR+ and ER-PR- breast cancer. Some heterogeneity exists in the risk factor profiles of ER+PR+ and ER-PR- premenopausal breast cancer; however, risk factor profiles did not differ markedly for postmenopausal breast cancer.

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  • Authors+Show Affiliations

    ,

    Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, M5G 2L7 Canada. michelle.cotterchio@cancercare.on.ca

    , , ,

    Source

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Breast Neoplasms
    Case-Control Studies
    Female
    Humans
    Menarche
    Middle Aged
    Obesity
    Odds Ratio
    Postmenopause
    Premenopause
    Receptors, Estrogen
    Receptors, Progesterone
    Regression Analysis
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14578142

    Citation

    Cotterchio, Michelle, et al. "Hormonal Factors and the Risk of Breast Cancer According to Estrogen- and Progesterone-receptor Subgroup." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 10, 2003, pp. 1053-60.
    Cotterchio M, Kreiger N, Theis B, et al. Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroup. Cancer Epidemiol Biomarkers Prev. 2003;12(10):1053-60.
    Cotterchio, M., Kreiger, N., Theis, B., Sloan, M., & Bahl, S. (2003). Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroup. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(10), pp. 1053-60.
    Cotterchio M, et al. Hormonal Factors and the Risk of Breast Cancer According to Estrogen- and Progesterone-receptor Subgroup. Cancer Epidemiol Biomarkers Prev. 2003;12(10):1053-60. PubMed PMID: 14578142.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroup. AU - Cotterchio,Michelle, AU - Kreiger,Nancy, AU - Theis,Beth, AU - Sloan,Margaret, AU - Bahl,Saira, PY - 2003/10/28/pubmed PY - 2004/3/23/medline PY - 2003/10/28/entrez SP - 1053 EP - 60 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 10 N2 - Evidence suggests hormonal factors may be more strongly associated with estrogen receptor+progesterone receptor+ (ER+PR+) than ER-PR- breast cancer risk. This study evaluated risk factors according to ERPR tumor status among pre- and postmenopausal women participating in two recent population-based case-control studies. Breast cancer cases, ages 25-74 years, and diagnosed 1995-1998 were sampled from the Ontario Cancer Registry. Controls were a random sample of women identified using the Ontario Ministry of Finance rolls and were frequency-matched to cases within 5-year age groups. Epidemiological data were collected from breast cancer cases and controls using two self-administered questionnaires. ERPR data were obtained for 87% of the breast cancer cases (3,276 of 3,748). Multivariate polytomous logistic regression was used to obtain odds ratios estimates and 95% confidence intervals. The following significant differences were observed in the risk factor profiles for ER+PR+ and ER-PR- breast cancer: among premenopausal women, late age at menarche was only associated with a reduction in ER+PR+ breast cancer risk; obesity was associated with an increased ER-PR- and decreased ER+PR+ cancer risk; and the association between alcohol intake and breast cancer risk was heterogeneous across ERPR subgroups, although the direction varied across the levels of alcohol intake. Among postmenopausal women, there were no statistically significant differences observed in the risk factor profiles for ER+PR+ and ER-PR- breast cancer. Some heterogeneity exists in the risk factor profiles of ER+PR+ and ER-PR- premenopausal breast cancer; however, risk factor profiles did not differ markedly for postmenopausal breast cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/14578142/Hormonal_factors_and_the_risk_of_breast_cancer_according_to_estrogen__and_progesterone_receptor_subgroup_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14578142 DB - PRIME DP - Unbound Medicine ER -