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Dialysis leg cramps. Efficacy of quinine versus vitamin E.

Abstract

A controlled randomized double-blind study was done to determine the frequency and severity of leg cramps in 40 patients on dialysis with a history of leg cramps. All patients entered a 2 month placebo washout and were randomized into a 2 month double-dummy phase of quinine 325 mg at bedtime versus vitamin E 400 IU at bedtime. Of the 29 patients completing the study, 16 received quinine and 13 vitamin E. During placebo washout, the vitamin E group had a mean of 10.4 leg cramps per month, and the quinine group had a mean of 10.9. The vitamin E and quinine groups had a 1 month reduction in leg cramps to 3.3 and 3.6, respectively (p < 0.0005 for both groups combined); this was sustained at 2 months. A severity of pain index showed a statistically significant decrease for both groups. The 95% confidence interval for the difference between the number of leg cramps after vitamin E versus quinine treatment (95% confidence interval, -3.8, +3.2) suggests similar efficacy. Quinine and vitamin E were effective treatments for leg cramps in these patients. Considering the potential toxicity of quinine, vitamin E is recommended as the initial treatment of choice for patients on dialysis with leg cramps.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Northeastern Ohio Universities College of Medicine, Rootstown.

    , , , , ,

    Source

    MeSH

    Adult
    Aged
    Double-Blind Method
    Female
    Humans
    Leg
    Male
    Middle Aged
    Muscle Cramp
    Quinine
    Renal Dialysis
    Vitamin E

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    1457907

    Citation

    Roca, A O., et al. "Dialysis Leg Cramps. Efficacy of Quinine Versus Vitamin E." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 38, no. 3, 1992, pp. M481-5.
    Roca AO, Jarjoura D, Blend D, et al. Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO J. 1992;38(3):M481-5.
    Roca, A. O., Jarjoura, D., Blend, D., Cugino, A., Rutecki, G. W., Nuchikat, P. S., & Whittier, F. C. (1992). Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 38(3), pp. M481-5.
    Roca AO, et al. Dialysis Leg Cramps. Efficacy of Quinine Versus Vitamin E. ASAIO J. 1992;38(3):M481-5. PubMed PMID: 1457907.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dialysis leg cramps. Efficacy of quinine versus vitamin E. AU - Roca,A O, AU - Jarjoura,D, AU - Blend,D, AU - Cugino,A, AU - Rutecki,G W, AU - Nuchikat,P S, AU - Whittier,F C, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - M481 EP - 5 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J. VL - 38 IS - 3 N2 - A controlled randomized double-blind study was done to determine the frequency and severity of leg cramps in 40 patients on dialysis with a history of leg cramps. All patients entered a 2 month placebo washout and were randomized into a 2 month double-dummy phase of quinine 325 mg at bedtime versus vitamin E 400 IU at bedtime. Of the 29 patients completing the study, 16 received quinine and 13 vitamin E. During placebo washout, the vitamin E group had a mean of 10.4 leg cramps per month, and the quinine group had a mean of 10.9. The vitamin E and quinine groups had a 1 month reduction in leg cramps to 3.3 and 3.6, respectively (p < 0.0005 for both groups combined); this was sustained at 2 months. A severity of pain index showed a statistically significant decrease for both groups. The 95% confidence interval for the difference between the number of leg cramps after vitamin E versus quinine treatment (95% confidence interval, -3.8, +3.2) suggests similar efficacy. Quinine and vitamin E were effective treatments for leg cramps in these patients. Considering the potential toxicity of quinine, vitamin E is recommended as the initial treatment of choice for patients on dialysis with leg cramps. SN - 1058-2916 UR - https://www.unboundmedicine.com/medline/citation/1457907/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=1457907 DB - PRIME DP - Unbound Medicine ER -