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Dialysis leg cramps. Efficacy of quinine versus vitamin E.
ASAIO J 1992 Jul-Sep; 38(3):M481-5AJ

Abstract

A controlled randomized double-blind study was done to determine the frequency and severity of leg cramps in 40 patients on dialysis with a history of leg cramps. All patients entered a 2 month placebo washout and were randomized into a 2 month double-dummy phase of quinine 325 mg at bedtime versus vitamin E 400 IU at bedtime. Of the 29 patients completing the study, 16 received quinine and 13 vitamin E. During placebo washout, the vitamin E group had a mean of 10.4 leg cramps per month, and the quinine group had a mean of 10.9. The vitamin E and quinine groups had a 1 month reduction in leg cramps to 3.3 and 3.6, respectively (p < 0.0005 for both groups combined); this was sustained at 2 months. A severity of pain index showed a statistically significant decrease for both groups. The 95% confidence interval for the difference between the number of leg cramps after vitamin E versus quinine treatment (95% confidence interval, -3.8, +3.2) suggests similar efficacy. Quinine and vitamin E were effective treatments for leg cramps in these patients. Considering the potential toxicity of quinine, vitamin E is recommended as the initial treatment of choice for patients on dialysis with leg cramps.

Authors+Show Affiliations

Department of Internal Medicine, Northeastern Ohio Universities College of Medicine, Rootstown.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1457907

Citation

Roca, A O., et al. "Dialysis Leg Cramps. Efficacy of Quinine Versus Vitamin E." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 38, no. 3, 1992, pp. M481-5.
Roca AO, Jarjoura D, Blend D, et al. Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO J. 1992;38(3):M481-5.
Roca, A. O., Jarjoura, D., Blend, D., Cugino, A., Rutecki, G. W., Nuchikat, P. S., & Whittier, F. C. (1992). Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 38(3), pp. M481-5.
Roca AO, et al. Dialysis Leg Cramps. Efficacy of Quinine Versus Vitamin E. ASAIO J. 1992;38(3):M481-5. PubMed PMID: 1457907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dialysis leg cramps. Efficacy of quinine versus vitamin E. AU - Roca,A O, AU - Jarjoura,D, AU - Blend,D, AU - Cugino,A, AU - Rutecki,G W, AU - Nuchikat,P S, AU - Whittier,F C, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - M481 EP - 5 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J. VL - 38 IS - 3 N2 - A controlled randomized double-blind study was done to determine the frequency and severity of leg cramps in 40 patients on dialysis with a history of leg cramps. All patients entered a 2 month placebo washout and were randomized into a 2 month double-dummy phase of quinine 325 mg at bedtime versus vitamin E 400 IU at bedtime. Of the 29 patients completing the study, 16 received quinine and 13 vitamin E. During placebo washout, the vitamin E group had a mean of 10.4 leg cramps per month, and the quinine group had a mean of 10.9. The vitamin E and quinine groups had a 1 month reduction in leg cramps to 3.3 and 3.6, respectively (p < 0.0005 for both groups combined); this was sustained at 2 months. A severity of pain index showed a statistically significant decrease for both groups. The 95% confidence interval for the difference between the number of leg cramps after vitamin E versus quinine treatment (95% confidence interval, -3.8, +3.2) suggests similar efficacy. Quinine and vitamin E were effective treatments for leg cramps in these patients. Considering the potential toxicity of quinine, vitamin E is recommended as the initial treatment of choice for patients on dialysis with leg cramps. SN - 1058-2916 UR - https://www.unboundmedicine.com/medline/citation/1457907/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=1457907 DB - PRIME DP - Unbound Medicine ER -