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Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study.

Abstract

BACKGROUND

Increased westernization with Japanese migration to the U. S. in the early 20(th) century is thought to have altered the risk of cardiovascular disease. Whether similar effects include changes in the risk of Parkinson's disease (PD) is not clear. This report describes the relations between environmental, life-style, and physical attributes and the incidence of PD that have been observed in the Honolulu-Asia Aging Study.

METHODS

Beginning in 1965, environmental, life-style, and physical attributes were recorded at selected examinations in a cohort of 8,006 Japanese-American men. Subjects were followed for clinical PD.

FINDINGS

During 30 years of follow- up, PD was observed in 137 men. Overall incidence (7.1/10,000 person-years) was generally higher than in Asia and similar to rates observed in Europe and the U. S. Precursors of PD included constipation, adiposity, years worked on a sugar or pineapple plantation, years of exposure to pesticides, and exposure to sugar cane processing. Factors showing an inverse association with PD included coffee intake and cigarette smoking. Among dietary factors, carbohydrates increased the risk of PD while the intake of polyunsaturated fats appeared protective. Total caloric intake, saturated and monounsaturated fats, protein, niacin, riboflavin, beta-carotene, vitamins A, B, and C, dietary cholesterol, cobalamin, alpha-tocopherol, and pantothenic acid showed no clear relation with clinical PD.

INTERPRETATION

Findings suggest that several environmental, life-style, and physical attributes appear to be precursors of PD. Whether patterns of precursors can be used to identify individuals at high risk of future PD or can broaden the scope of early interventions or recruitment into neuroprotective trials warrants further study.

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  • Authors+Show Affiliations

    ,

    University of Virginia Health System, Department of Health Evaluation Sciences, 800717, Charlottesville, Virginia 22908-0717, USA. rda3e@virginia.edu

    , , , , , , , ,

    Source

    Journal of neurology 250 Suppl 3: 2003 Oct pg III30-9

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Asia
    Body Composition
    Coffee
    Constipation
    Diet
    Environmental Exposure
    Humans
    Incidence
    Life Style
    Male
    Middle Aged
    Parkinson Disease
    Pesticides
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    14579122

    Citation

    Abbott, Robert D., et al. "Environmental, Life-style, and Physical Precursors of Clinical Parkinson's Disease: Recent Findings From the Honolulu-Asia Aging Study." Journal of Neurology, vol. 250 Suppl 3, 2003, pp. III30-9.
    Abbott RD, Ross GW, White LR, et al. Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study. J Neurol. 2003;250 Suppl 3:III30-9.
    Abbott, R. D., Ross, G. W., White, L. R., Sanderson, W. T., Burchfiel, C. M., Kashon, M., ... Petrovitch, H. (2003). Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study. Journal of Neurology, 250 Suppl 3, pp. III30-9.
    Abbott RD, et al. Environmental, Life-style, and Physical Precursors of Clinical Parkinson's Disease: Recent Findings From the Honolulu-Asia Aging Study. J Neurol. 2003;250 Suppl 3:III30-9. PubMed PMID: 14579122.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study. AU - Abbott,Robert D, AU - Ross,G Webster, AU - White,Lon R, AU - Sanderson,Wayne T, AU - Burchfiel,Cecil M, AU - Kashon,Michael, AU - Sharp,Dan S, AU - Masaki,Kamal H, AU - Curb,J David, AU - Petrovitch,Helen, PY - 2003/10/28/pubmed PY - 2004/1/30/medline PY - 2003/10/28/entrez SP - III30 EP - 9 JF - Journal of neurology JO - J. Neurol. VL - 250 Suppl 3 N2 - BACKGROUND: Increased westernization with Japanese migration to the U. S. in the early 20(th) century is thought to have altered the risk of cardiovascular disease. Whether similar effects include changes in the risk of Parkinson's disease (PD) is not clear. This report describes the relations between environmental, life-style, and physical attributes and the incidence of PD that have been observed in the Honolulu-Asia Aging Study. METHODS: Beginning in 1965, environmental, life-style, and physical attributes were recorded at selected examinations in a cohort of 8,006 Japanese-American men. Subjects were followed for clinical PD. FINDINGS: During 30 years of follow- up, PD was observed in 137 men. Overall incidence (7.1/10,000 person-years) was generally higher than in Asia and similar to rates observed in Europe and the U. S. Precursors of PD included constipation, adiposity, years worked on a sugar or pineapple plantation, years of exposure to pesticides, and exposure to sugar cane processing. Factors showing an inverse association with PD included coffee intake and cigarette smoking. Among dietary factors, carbohydrates increased the risk of PD while the intake of polyunsaturated fats appeared protective. Total caloric intake, saturated and monounsaturated fats, protein, niacin, riboflavin, beta-carotene, vitamins A, B, and C, dietary cholesterol, cobalamin, alpha-tocopherol, and pantothenic acid showed no clear relation with clinical PD. INTERPRETATION: Findings suggest that several environmental, life-style, and physical attributes appear to be precursors of PD. Whether patterns of precursors can be used to identify individuals at high risk of future PD or can broaden the scope of early interventions or recruitment into neuroprotective trials warrants further study. SN - 0340-5354 UR - https://www.unboundmedicine.com/medline/citation/14579122/Environmental_life_style_and_physical_precursors_of_clinical_Parkinson's_disease:_recent_findings_from_the_Honolulu_Asia_Aging_Study_ L2 - https://dx.doi.org/10.1007/s00415-003-1306-7 DB - PRIME DP - Unbound Medicine ER -