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Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception.
BMJ. 1992 Oct 17; 305(6859):927-31.BMJ

Abstract

OBJECTIVE

To compare the effectiveness and acceptability of three regimens of postcoital contraception.

DESIGN

Randomised group comparison of ethinyloestradiol 100 micrograms plus levonorgestrel 500 micrograms repeated after 12 hours (Yuzpe method); danazol 600 mg repeated after 12 hours; and mifepristone 600 mg single dose.

SETTING

Community family planning clinic.

SUBJECTS

616 consecutive women with regular cycles aged 16 to 45 years.

MAIN OUTCOME MEASURES

Number of pregnancies, incidence of side effects, and timing of next period.

RESULTS

The raw pregnancy rates (with 95% confidence intervals) for the Yuzpe, danazol, and mifepristone groups were 2.62% (0.86% to 6.00%), 4.66% (2.15% to 8.67%), and 0% (0% to 1.87%) respectively. Overall, these rates differed significantly (chi 2 = 8.988, df = 2; p = 0.011). The differences between the mifepristone and Yuzpe groups and between the mifepristone and danazol groups were also significant. Side effects were more common and more severe in the Yuzpe group (133 women (70%)) than in either the danazol group (58 (30%)) or the mifepristone group (72 (37%)). The Yuzpe regimen tended to induce bleeding early but mifepristone prolonged the cycle. Three women bled more than seven days late in the Yuzpe group compared with 49 in the mifepristone group.

CONCLUSIONS

Mifepristone was effective in reducing expected pregnancy rates and the Yuzpe method also had a clinical effect. Danazol had little or no effect. A further multicentre trial is needed.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, University of Manchester.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1458074

Citation

Webb, A M., et al. "Comparison of Yuzpe Regimen, Danazol, and Mifepristone (RU486) in Oral Postcoital Contraception." BMJ (Clinical Research Ed.), vol. 305, no. 6859, 1992, pp. 927-31.
Webb AM, Russell J, Elstein M. Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception. BMJ. 1992;305(6859):927-31.
Webb, A. M., Russell, J., & Elstein, M. (1992). Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception. BMJ (Clinical Research Ed.), 305(6859), 927-31.
Webb AM, Russell J, Elstein M. Comparison of Yuzpe Regimen, Danazol, and Mifepristone (RU486) in Oral Postcoital Contraception. BMJ. 1992 Oct 17;305(6859):927-31. PubMed PMID: 1458074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception. AU - Webb,A M, AU - Russell,J, AU - Elstein,M, PY - 1992/10/17/pubmed PY - 1992/10/17/medline PY - 1992/10/17/entrez KW - Biology KW - Bleeding KW - Clinical Research KW - Clinical Trials KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen--side effects KW - Contraceptive Agents, Female KW - Contraceptive Agents, Female--side effects KW - Contraceptive Agents, Postcoital KW - Contraceptive Agents, Progestin--side effects KW - Contraceptive Agents--side effects KW - Contraceptive Effectiveness KW - Contraceptive Usage KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Endocrine System KW - England KW - Ethinyl Estradiol--side effects KW - Europe KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Hormone Antagonists KW - Hormones KW - Levonorgestrel--side effects KW - Method Acceptability KW - Methodological Studies KW - Northern Europe KW - Physiology KW - Population KW - Population Dynamics KW - Pregnancy Rate KW - Research Methodology KW - Ru-486 KW - Signs And Symptoms KW - Studies KW - United Kingdom SP - 927 EP - 31 JF - BMJ (Clinical research ed.) JO - BMJ VL - 305 IS - 6859 N2 - OBJECTIVE: To compare the effectiveness and acceptability of three regimens of postcoital contraception. DESIGN: Randomised group comparison of ethinyloestradiol 100 micrograms plus levonorgestrel 500 micrograms repeated after 12 hours (Yuzpe method); danazol 600 mg repeated after 12 hours; and mifepristone 600 mg single dose. SETTING: Community family planning clinic. SUBJECTS: 616 consecutive women with regular cycles aged 16 to 45 years. MAIN OUTCOME MEASURES: Number of pregnancies, incidence of side effects, and timing of next period. RESULTS: The raw pregnancy rates (with 95% confidence intervals) for the Yuzpe, danazol, and mifepristone groups were 2.62% (0.86% to 6.00%), 4.66% (2.15% to 8.67%), and 0% (0% to 1.87%) respectively. Overall, these rates differed significantly (chi 2 = 8.988, df = 2; p = 0.011). The differences between the mifepristone and Yuzpe groups and between the mifepristone and danazol groups were also significant. Side effects were more common and more severe in the Yuzpe group (133 women (70%)) than in either the danazol group (58 (30%)) or the mifepristone group (72 (37%)). The Yuzpe regimen tended to induce bleeding early but mifepristone prolonged the cycle. Three women bled more than seven days late in the Yuzpe group compared with 49 in the mifepristone group. CONCLUSIONS: Mifepristone was effective in reducing expected pregnancy rates and the Yuzpe method also had a clinical effect. Danazol had little or no effect. A further multicentre trial is needed. SN - 0959-8138 UR - https://www.unboundmedicine.com/medline/citation/1458074/Comparison_of_Yuzpe_regimen_danazol_and_mifepristone__RU486__in_oral_postcoital_contraception_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1458074/ DB - PRIME DP - Unbound Medicine ER -