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Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors.
Exp Gerontol 2003; 38(10):1199-203EG

Abstract

Intramuscular (IM) influenza vaccines are about 50% effective in preventing respiratory illness among the elderly. The aim of this study was to identify factors associated with immune response to influenza vaccination among nursing home and community-residing elderly. 114 nursing home (NHE) and 62 community residing elderly (CE) were vaccinated with a commercial IM vaccine. Serum antibodies were evaluated by HIA, and the impact of subjects' clinical characteristics on seroconversion was determined. Factors that were associated with low seroconversion among NHE, included: type II diabetes [for B/Harbin: p=0.044, OR 0.12, (CI: 0.015-0.94)], and antibody titer prior to vaccination A/(H1N1): p=0.03, OR 2.38, (CI: 1.09-5.22); A/(H3N2): p=0.015, OR 2.68 (CI: 1.22-5.92), B/Harbin: p=0.057, OR 4.46 (CI: 0.96-20.85)]. Factors that were associated with lower seroconversion CE elderly, included older age [A/(H1N1): p=0.008, OR 0.846, (CI 0.75-0.96), B/Harbin: p=0.016, OR 0.812, (CI:0.69-0.96)], and antibody titer prior to vaccination A/(H1N1): p=0.029, OR 4.08, (CI: 1.16-14.37); A/(H3N2): p<0.0001, OR 11.495 (CI: 3.18-41.55)]. There was no significant difference in seroconversion between nursing home residing elderly and community elderly. We conclude that Type-II diabetes and antibody titer>1:40 prior to vaccination are associated with reduced response to the influenza vaccination in nursing home elderly.

Authors+Show Affiliations

Department of Medicine, Unit of Geriatrics, Hadassah University Hospital, PO Box 12000, 91120, Jerusalem, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14580873

Citation

Muszkat, Mordechai, et al. "Response to Influenza Vaccination in Community and in Nursing Home Residing Elderly: Relation to Clinical Factors." Experimental Gerontology, vol. 38, no. 10, 2003, pp. 1199-203.
Muszkat M, Friedman G, Dannenberg HD, et al. Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. Exp Gerontol. 2003;38(10):1199-203.
Muszkat, M., Friedman, G., Dannenberg, H. D., Greenbaum, E., Lipo, M., Heymann, Y., ... Ben-Yehuda, A. (2003). Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. Experimental Gerontology, 38(10), pp. 1199-203.
Muszkat M, et al. Response to Influenza Vaccination in Community and in Nursing Home Residing Elderly: Relation to Clinical Factors. Exp Gerontol. 2003;38(10):1199-203. PubMed PMID: 14580873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. AU - Muszkat,Mordechai, AU - Friedman,Gideon, AU - Dannenberg,Haim D, AU - Greenbaum,Eugenia, AU - Lipo,Mordechai, AU - Heymann,Ya'acov, AU - Zakay-Rones,Zichria, AU - Ben-Yehuda,Arie, PY - 2003/10/29/pubmed PY - 2004/4/17/medline PY - 2003/10/29/entrez SP - 1199 EP - 203 JF - Experimental gerontology JO - Exp. Gerontol. VL - 38 IS - 10 N2 - Intramuscular (IM) influenza vaccines are about 50% effective in preventing respiratory illness among the elderly. The aim of this study was to identify factors associated with immune response to influenza vaccination among nursing home and community-residing elderly. 114 nursing home (NHE) and 62 community residing elderly (CE) were vaccinated with a commercial IM vaccine. Serum antibodies were evaluated by HIA, and the impact of subjects' clinical characteristics on seroconversion was determined. Factors that were associated with low seroconversion among NHE, included: type II diabetes [for B/Harbin: p=0.044, OR 0.12, (CI: 0.015-0.94)], and antibody titer prior to vaccination A/(H1N1): p=0.03, OR 2.38, (CI: 1.09-5.22); A/(H3N2): p=0.015, OR 2.68 (CI: 1.22-5.92), B/Harbin: p=0.057, OR 4.46 (CI: 0.96-20.85)]. Factors that were associated with lower seroconversion CE elderly, included older age [A/(H1N1): p=0.008, OR 0.846, (CI 0.75-0.96), B/Harbin: p=0.016, OR 0.812, (CI:0.69-0.96)], and antibody titer prior to vaccination A/(H1N1): p=0.029, OR 4.08, (CI: 1.16-14.37); A/(H3N2): p<0.0001, OR 11.495 (CI: 3.18-41.55)]. There was no significant difference in seroconversion between nursing home residing elderly and community elderly. We conclude that Type-II diabetes and antibody titer>1:40 prior to vaccination are associated with reduced response to the influenza vaccination in nursing home elderly. SN - 0531-5565 UR - https://www.unboundmedicine.com/medline/citation/14580873/Response_to_influenza_vaccination_in_community_and_in_nursing_home_residing_elderly:_relation_to_clinical_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531556503002146 DB - PRIME DP - Unbound Medicine ER -