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Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors.

Abstract

Intramuscular (IM) influenza vaccines are about 50% effective in preventing respiratory illness among the elderly. The aim of this study was to identify factors associated with immune response to influenza vaccination among nursing home and community-residing elderly. 114 nursing home (NHE) and 62 community residing elderly (CE) were vaccinated with a commercial IM vaccine. Serum antibodies were evaluated by HIA, and the impact of subjects' clinical characteristics on seroconversion was determined. Factors that were associated with low seroconversion among NHE, included: type II diabetes [for B/Harbin: p=0.044, OR 0.12, (CI: 0.015-0.94)], and antibody titer prior to vaccination A/(H1N1): p=0.03, OR 2.38, (CI: 1.09-5.22); A/(H3N2): p=0.015, OR 2.68 (CI: 1.22-5.92), B/Harbin: p=0.057, OR 4.46 (CI: 0.96-20.85)]. Factors that were associated with lower seroconversion CE elderly, included older age [A/(H1N1): p=0.008, OR 0.846, (CI 0.75-0.96), B/Harbin: p=0.016, OR 0.812, (CI:0.69-0.96)], and antibody titer prior to vaccination A/(H1N1): p=0.029, OR 4.08, (CI: 1.16-14.37); A/(H3N2): p<0.0001, OR 11.495 (CI: 3.18-41.55)]. There was no significant difference in seroconversion between nursing home residing elderly and community elderly. We conclude that Type-II diabetes and antibody titer>1:40 prior to vaccination are associated with reduced response to the influenza vaccination in nursing home elderly.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Unit of Geriatrics, Hadassah University Hospital, PO Box 12000, 91120, Jerusalem, Israel.

    , , , , , ,

    Source

    Experimental gerontology 38:10 2003 Oct pg 1199-203

    MeSH

    Aged
    Aged, 80 and over
    Antibodies, Viral
    Community Health Services
    Diabetes Mellitus, Type 2
    Female
    Geriatric Assessment
    Hemagglutination Inhibition Tests
    Homes for the Aged
    Humans
    Influenza A virus
    Influenza B virus
    Influenza Vaccines
    Influenza, Human
    Logistic Models
    Male
    Middle Aged
    Nursing Homes
    Residence Characteristics
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    14580873

    Citation

    Muszkat, Mordechai, et al. "Response to Influenza Vaccination in Community and in Nursing Home Residing Elderly: Relation to Clinical Factors." Experimental Gerontology, vol. 38, no. 10, 2003, pp. 1199-203.
    Muszkat M, Friedman G, Dannenberg HD, et al. Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. Exp Gerontol. 2003;38(10):1199-203.
    Muszkat, M., Friedman, G., Dannenberg, H. D., Greenbaum, E., Lipo, M., Heymann, Y., ... Ben-Yehuda, A. (2003). Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. Experimental Gerontology, 38(10), pp. 1199-203.
    Muszkat M, et al. Response to Influenza Vaccination in Community and in Nursing Home Residing Elderly: Relation to Clinical Factors. Exp Gerontol. 2003;38(10):1199-203. PubMed PMID: 14580873.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. AU - Muszkat,Mordechai, AU - Friedman,Gideon, AU - Dannenberg,Haim D, AU - Greenbaum,Eugenia, AU - Lipo,Mordechai, AU - Heymann,Ya'acov, AU - Zakay-Rones,Zichria, AU - Ben-Yehuda,Arie, PY - 2003/10/29/pubmed PY - 2004/4/17/medline PY - 2003/10/29/entrez SP - 1199 EP - 203 JF - Experimental gerontology JO - Exp. Gerontol. VL - 38 IS - 10 N2 - Intramuscular (IM) influenza vaccines are about 50% effective in preventing respiratory illness among the elderly. The aim of this study was to identify factors associated with immune response to influenza vaccination among nursing home and community-residing elderly. 114 nursing home (NHE) and 62 community residing elderly (CE) were vaccinated with a commercial IM vaccine. Serum antibodies were evaluated by HIA, and the impact of subjects' clinical characteristics on seroconversion was determined. Factors that were associated with low seroconversion among NHE, included: type II diabetes [for B/Harbin: p=0.044, OR 0.12, (CI: 0.015-0.94)], and antibody titer prior to vaccination A/(H1N1): p=0.03, OR 2.38, (CI: 1.09-5.22); A/(H3N2): p=0.015, OR 2.68 (CI: 1.22-5.92), B/Harbin: p=0.057, OR 4.46 (CI: 0.96-20.85)]. Factors that were associated with lower seroconversion CE elderly, included older age [A/(H1N1): p=0.008, OR 0.846, (CI 0.75-0.96), B/Harbin: p=0.016, OR 0.812, (CI:0.69-0.96)], and antibody titer prior to vaccination A/(H1N1): p=0.029, OR 4.08, (CI: 1.16-14.37); A/(H3N2): p<0.0001, OR 11.495 (CI: 3.18-41.55)]. There was no significant difference in seroconversion between nursing home residing elderly and community elderly. We conclude that Type-II diabetes and antibody titer>1:40 prior to vaccination are associated with reduced response to the influenza vaccination in nursing home elderly. SN - 0531-5565 UR - https://www.unboundmedicine.com/medline/citation/14580873/Response_to_influenza_vaccination_in_community_and_in_nursing_home_residing_elderly:_relation_to_clinical_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531556503002146 DB - PRIME DP - Unbound Medicine ER -