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Peritoneal fluid environment in endometriosis. Clinicopathological implications.

Abstract

Endometriosis is a puzzling disorder with obscure pathogenesis. The objective of this review was to evaluate the complex role of peritoneal fluid in the etiopathogenesis of endometriosis. Several studies suggest that peritoneal fluid is a key inflammatory environment associated with endometriosis. Many active substances (cytokines, growth factors, hormones and oxidative stress parameters) have been identified in endometriosis patients at different stages of the disease. Inflammatory mediators may be involved in the endometriosis associated-infertility and possibly pain. Furthermore, these mediators may represent a non surgical method for diagnosing endometriosis. Better understanding of the mechanism of cytokines, growth factor and reactive oxygen species production and detoxification and further investigation of their effects on the peritoneal fluid environment are essential to obtain new insight into this disease and eventually develop novel diagnostic and therapeutic remedies.

Authors+Show Affiliations

,

Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Source

Minerva ginecologica 55:4 2003 Aug pg 333-45

MeSH

Ascitic Fluid
Endometriosis
Female
Humans
Immunologic Factors
Infertility, Female
Oxidative Stress

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14581858

Citation

Bedaiwy, M A., and T Falcone. "Peritoneal Fluid Environment in Endometriosis. Clinicopathological Implications." Minerva Ginecologica, vol. 55, no. 4, 2003, pp. 333-45.
Bedaiwy MA, Falcone T. Peritoneal fluid environment in endometriosis. Clinicopathological implications. Minerva Ginecol. 2003;55(4):333-45.
Bedaiwy, M. A., & Falcone, T. (2003). Peritoneal fluid environment in endometriosis. Clinicopathological implications. Minerva Ginecologica, 55(4), pp. 333-45.
Bedaiwy MA, Falcone T. Peritoneal Fluid Environment in Endometriosis. Clinicopathological Implications. Minerva Ginecol. 2003;55(4):333-45. PubMed PMID: 14581858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peritoneal fluid environment in endometriosis. Clinicopathological implications. AU - Bedaiwy,M A, AU - Falcone,T, PY - 2003/10/29/pubmed PY - 2004/2/14/medline PY - 2003/10/29/entrez SP - 333 EP - 45 JF - Minerva ginecologica JO - Minerva Ginecol VL - 55 IS - 4 N2 - Endometriosis is a puzzling disorder with obscure pathogenesis. The objective of this review was to evaluate the complex role of peritoneal fluid in the etiopathogenesis of endometriosis. Several studies suggest that peritoneal fluid is a key inflammatory environment associated with endometriosis. Many active substances (cytokines, growth factors, hormones and oxidative stress parameters) have been identified in endometriosis patients at different stages of the disease. Inflammatory mediators may be involved in the endometriosis associated-infertility and possibly pain. Furthermore, these mediators may represent a non surgical method for diagnosing endometriosis. Better understanding of the mechanism of cytokines, growth factor and reactive oxygen species production and detoxification and further investigation of their effects on the peritoneal fluid environment are essential to obtain new insight into this disease and eventually develop novel diagnostic and therapeutic remedies. SN - 0026-4784 UR - https://www.unboundmedicine.com/medline/citation/14581858/Peritoneal_fluid_environment_in_endometriosis__Clinicopathological_implications_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -