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Diagnosis and treatment of malaria in children.
Clin Infect Dis. 2003 Nov 15; 37(10):1340-8.CI

Abstract

Malaria continues to be a problem for children returning or immigrating to industrialized countries from tropical regions. Proper diagnosis begins with clinical suspicion. In nonimmune children, malaria typically presents with high fever that might be accompanied by chills and headache. Symptoms and signs may be more subtle in partially immune children, and anemia and hepatosplenomegaly may also be present. Children may present with respiratory distress and/or rapidly progressing cerebral malaria that manifests as altered sensorium and, sometimes, seizures. Thick blood smears help to determine when infection is present, but a single smear without parasites is not sufficient to rule out malaria. Thin blood smears aid in identifying the species of parasite. Treatment must include careful supportive care, and intensive care measures should be available for treating children with complicated Plasmodium falciparum malaria. Medical regimens can include mefloquine, atovaquone-proguanil, sulfadoxine-pyrimethamine, quinine or quinidine, clindamycin, doxycycline, chloroquine, and primaquine.

Authors+Show Affiliations

Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, St. Paul, MN, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14583868

Citation

Stauffer, William, and Philip R. Fischer. "Diagnosis and Treatment of Malaria in Children." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 37, no. 10, 2003, pp. 1340-8.
Stauffer W, Fischer PR. Diagnosis and treatment of malaria in children. Clin Infect Dis. 2003;37(10):1340-8.
Stauffer, W., & Fischer, P. R. (2003). Diagnosis and treatment of malaria in children. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 37(10), 1340-8.
Stauffer W, Fischer PR. Diagnosis and Treatment of Malaria in Children. Clin Infect Dis. 2003 Nov 15;37(10):1340-8. PubMed PMID: 14583868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and treatment of malaria in children. AU - Stauffer,William, AU - Fischer,Philip R, Y1 - 2003/10/17/ PY - 2003/05/06/received PY - 2003/07/09/accepted PY - 2003/10/30/pubmed PY - 2004/1/28/medline PY - 2003/10/30/entrez SP - 1340 EP - 8 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 37 IS - 10 N2 - Malaria continues to be a problem for children returning or immigrating to industrialized countries from tropical regions. Proper diagnosis begins with clinical suspicion. In nonimmune children, malaria typically presents with high fever that might be accompanied by chills and headache. Symptoms and signs may be more subtle in partially immune children, and anemia and hepatosplenomegaly may also be present. Children may present with respiratory distress and/or rapidly progressing cerebral malaria that manifests as altered sensorium and, sometimes, seizures. Thick blood smears help to determine when infection is present, but a single smear without parasites is not sufficient to rule out malaria. Thin blood smears aid in identifying the species of parasite. Treatment must include careful supportive care, and intensive care measures should be available for treating children with complicated Plasmodium falciparum malaria. Medical regimens can include mefloquine, atovaquone-proguanil, sulfadoxine-pyrimethamine, quinine or quinidine, clindamycin, doxycycline, chloroquine, and primaquine. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/14583868/Diagnosis_and_treatment_of_malaria_in_children_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/379074 DB - PRIME DP - Unbound Medicine ER -