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Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003.
Lancet. 2003 Oct 25; 362(9393):1353-8.Lct

Abstract

BACKGROUND

An epidemic of severe acute respiratory syndrome (SARS) has been associated with an outbreak of atypical pneumonia originating in Guangdong Province, People's Republic of China. We aimed to identify the causative agent in the Guangdong outbreak and describe the emergence and spread of the disease within the province.

METHODS

We analysed epidemiological information and collected serum and nasopharyngeal aspirates from patients with SARS in Guangdong in mid-February, 2003. We did virus isolation, serological tests, and molecular assays to identify the causative agent.

FINDINGS

SARS had been circulating in other cities of Guangdong Province for about 2 months before causing a major outbreak in Guangzhou, the province's capital. A novel coronavirus, SARS coronavirus (CoV), was isolated from specimens from three patients with SARS. Viral antigens were also directly detected in nasopharyngeal aspirates from these patients. 48 of 55 (87%) patients had antibodies to SARS CoV in their convalescent sera. Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world.

INTERPRETATION

SARS CoV is the infectious agent responsible for the epidemic outbreak of SARS in Guangdong. The virus isolated from patients in Guangdong is the prototype of the SARS CoV in other regions and countries.

Links

PMC Free PDF

Authors+Show Affiliations

Zhong NS
Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College, Guangdong Province, Guangzhou, People's Republic of China.
Zheng BJ
No affiliation info available
Li YM
No affiliation info available
Poon
No affiliation info available
Xie ZH
No affiliation info available
Chan KH
No affiliation info available
Li PH
No affiliation info available
Tan SY
No affiliation info available
Chang Q
No affiliation info available
Xie JP
No affiliation info available
Liu XQ
No affiliation info available
Xu J
No affiliation info available
Li DX
No affiliation info available
Yuen KY
No affiliation info available
Peiris
No affiliation info available
Guan Y
No affiliation info available

MeSH

ChinaDisease OutbreaksHumansSevere acute respiratory syndrome-related coronavirusSevere Acute Respiratory Syndrome

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14585636

Clinical Trial Links

Primary Prevention of Infection by COVID-19 in Workers
Nutrition, Immunity, and Covid-19 in Obese People

Citation

Zhong, N S., et al. "Epidemiology and Cause of Severe Acute Respiratory Syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003." Lancet (London, England), vol. 362, no. 9393, 2003, pp. 1353-8.
Zhong NS, Zheng BJ, Li YM, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet. 2003;362(9393):1353-8.
Zhong, N. S., Zheng, B. J., Li, Y. M., Poon, ., Xie, Z. H., Chan, K. H., Li, P. H., Tan, S. Y., Chang, Q., Xie, J. P., Liu, X. Q., Xu, J., Li, D. X., Yuen, K. Y., Peiris, ., & Guan, Y. (2003). Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet (London, England), 362(9393), 1353-8.
Zhong NS, et al. Epidemiology and Cause of Severe Acute Respiratory Syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet. 2003 Oct 25;362(9393):1353-8. PubMed PMID: 14585636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. AU - Zhong,N S, AU - Zheng,B J, AU - Li,Y M, AU - Poon,, AU - Xie,Z H, AU - Chan,K H, AU - Li,P H, AU - Tan,S Y, AU - Chang,Q, AU - Xie,J P, AU - Liu,X Q, AU - Xu,J, AU - Li,D X, AU - Yuen,K Y, AU - Peiris,, AU - Guan,Y, PY - 2003/10/31/pubmed PY - 2004/1/13/medline PY - 2003/10/31/entrez SP - 1353 EP - 8 JF - Lancet (London, England) JO - Lancet VL - 362 IS - 9393 N2 - BACKGROUND: An epidemic of severe acute respiratory syndrome (SARS) has been associated with an outbreak of atypical pneumonia originating in Guangdong Province, People's Republic of China. We aimed to identify the causative agent in the Guangdong outbreak and describe the emergence and spread of the disease within the province. METHODS: We analysed epidemiological information and collected serum and nasopharyngeal aspirates from patients with SARS in Guangdong in mid-February, 2003. We did virus isolation, serological tests, and molecular assays to identify the causative agent. FINDINGS: SARS had been circulating in other cities of Guangdong Province for about 2 months before causing a major outbreak in Guangzhou, the province's capital. A novel coronavirus, SARS coronavirus (CoV), was isolated from specimens from three patients with SARS. Viral antigens were also directly detected in nasopharyngeal aspirates from these patients. 48 of 55 (87%) patients had antibodies to SARS CoV in their convalescent sera. Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world. INTERPRETATION: SARS CoV is the infectious agent responsible for the epidemic outbreak of SARS in Guangdong. The virus isolated from patients in Guangdong is the prototype of the SARS CoV in other regions and countries. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/14585636/Epidemiology_and_cause_of_severe_acute_respiratory_syndrome__SARS__in_Guangdong_People's_Republic_of_China_in_February_2003_ DB - PRIME DP - Unbound Medicine ER -