Tags

Type your tag names separated by a space and hit enter

Placental villitis of unclear etiology during ovum donor in vitro fertilization pregnancy.
Am J Obstet Gynecol. 2003 Oct; 189(4):1184-6.AJ

Abstract

OBJECTIVE

Preliminary observations by a single pathologist at our institution revealed a 75% incidence of villitis of unexplained etiology in ovum donor in vitro fertilization pregnancies. Because the incidence of villitis of unexplained etiology in the general population is approximately 10%, we conducted a controlled study to compare the incidence of villitis of unexplained etiology in ovum donor in vitro fertilization pregnancies to that in in vitro fertilization pregnancies that do not use donated ova.

STUDY DESIGN

Placental specimens of ovum donor in vitro fertilization pregnancies were matched randomly with pregnancies that resulted from both fresh and frozen/thawed native oocyte in vitro fertilization from March 5, 1995, to October 10, 2001, and examined in a blinded fashion by a single pathologist (D. J. R.) for villitis of unexplained cause. The incidence of villitis of unexplained etiology was analyzed in 27 patients who underwent ovum donor in vitro fertilization versus 37 patients who underwent native oocyte in vitro fertilization.

RESULTS

Villitis of unexplained cause occurred in 22.2% of ovum donor in vitro fertilization pregnancies, 10.8% of native oocyte in vitro fertilization pregnancies (fresh and frozen/thawed combined), and 14.3% of frozen/thawed cycles (P=.21).

CONCLUSION

Although the incidence was not statistically different than in in vitro fertilization that used native maternal oocytes, there was a 2-fold increase in villitis of unexplained cause in the ovum donor in vitro fertilization placentas, which suggests that immune-related disorders may be increased in ovum donor pregnancies.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14586376

Citation

Styer, Aaron K., et al. "Placental Villitis of Unclear Etiology During Ovum Donor in Vitro Fertilization Pregnancy." American Journal of Obstetrics and Gynecology, vol. 189, no. 4, 2003, pp. 1184-6.
Styer AK, Parker HJ, Roberts DJ, et al. Placental villitis of unclear etiology during ovum donor in vitro fertilization pregnancy. Am J Obstet Gynecol. 2003;189(4):1184-6.
Styer, A. K., Parker, H. J., Roberts, D. J., Palmer-Toy, D., Toth, T. L., & Ecker, J. L. (2003). Placental villitis of unclear etiology during ovum donor in vitro fertilization pregnancy. American Journal of Obstetrics and Gynecology, 189(4), 1184-6.
Styer AK, et al. Placental Villitis of Unclear Etiology During Ovum Donor in Vitro Fertilization Pregnancy. Am J Obstet Gynecol. 2003;189(4):1184-6. PubMed PMID: 14586376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental villitis of unclear etiology during ovum donor in vitro fertilization pregnancy. AU - Styer,Aaron K, AU - Parker,Hannah J, AU - Roberts,Drucilla J, AU - Palmer-Toy,Darryl, AU - Toth,Thomas L, AU - Ecker,Jeffrey L, PY - 2003/10/31/pubmed PY - 2003/12/3/medline PY - 2003/10/31/entrez SP - 1184 EP - 6 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 189 IS - 4 N2 - OBJECTIVE: Preliminary observations by a single pathologist at our institution revealed a 75% incidence of villitis of unexplained etiology in ovum donor in vitro fertilization pregnancies. Because the incidence of villitis of unexplained etiology in the general population is approximately 10%, we conducted a controlled study to compare the incidence of villitis of unexplained etiology in ovum donor in vitro fertilization pregnancies to that in in vitro fertilization pregnancies that do not use donated ova. STUDY DESIGN: Placental specimens of ovum donor in vitro fertilization pregnancies were matched randomly with pregnancies that resulted from both fresh and frozen/thawed native oocyte in vitro fertilization from March 5, 1995, to October 10, 2001, and examined in a blinded fashion by a single pathologist (D. J. R.) for villitis of unexplained cause. The incidence of villitis of unexplained etiology was analyzed in 27 patients who underwent ovum donor in vitro fertilization versus 37 patients who underwent native oocyte in vitro fertilization. RESULTS: Villitis of unexplained cause occurred in 22.2% of ovum donor in vitro fertilization pregnancies, 10.8% of native oocyte in vitro fertilization pregnancies (fresh and frozen/thawed combined), and 14.3% of frozen/thawed cycles (P=.21). CONCLUSION: Although the incidence was not statistically different than in in vitro fertilization that used native maternal oocytes, there was a 2-fold increase in villitis of unexplained cause in the ovum donor in vitro fertilization placentas, which suggests that immune-related disorders may be increased in ovum donor pregnancies. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/14586376/Placental_villitis_of_unclear_etiology_during_ovum_donor_in_vitro_fertilization_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937803005775 DB - PRIME DP - Unbound Medicine ER -