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Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis.
BMC Cancer. 2003 Oct 31; 3:28.BC

Abstract

BACKGROUND

Observational studies have consistently shown that aspirin and non-steroidal anti-inflammatory drug (NSAID) use is associated with a close to 50% reduced risk of colorectal cancer. Studies assessing the effects of NSAIDs on other cancers have shown conflicting results. Therefore, we conducted a meta-analysis to evaluate the relationship between NSAID use and cancer other than colorectal.

METHODS

We performed a search in Medline (from 1966 to 2002) and identified a total of 47 articles (13 cohort and 34 case-control studies). Overall estimates of the relative risk (RR) were calculated for each cancer site using random effects models.

RESULTS

Aspirin use was associated with a reduced risk of cancer of the esophagus and the stomach (RR, 0.51; 95%CI (0.38-0.69), and 0.73; 95%CI (0.63-0.84)). Use of NSAIDs was similarly associated with a lower risk of esophageal and gastric cancers (RR,0.65; 95% CI(0.46-0.92) and RR,0.54; 95%CI (0.39-0.75)). Among other cancers, only the results obtained for breast cancer were fairly consistent in showing a slight reduced risk among NSAID and aspirin users (RR, 0.77; 95%CI (0.66-0.88), and RR, 0.77; 95%CI (0.69-0.86) respectively)).

CONCLUSIONS

The results of this meta-analysis show that the potential chemopreventive role of NSAIDs in colorectal cancer might be extended to other gastrointestinal cancers such as esophagus and stomach. Further research is required to evaluate the role of NSAIDs at other cancers sites.

Authors+Show Affiliations

Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain. agonzalez@ceife.esNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14588079

Citation

González-Pérez, Antonio, et al. "Effects of Non-steroidal Anti-inflammatory Drugs On Cancer Sites Other Than the Colon and Rectum: a Meta-analysis." BMC Cancer, vol. 3, 2003, p. 28.
González-Pérez A, García Rodríguez LA, López-Ridaura R. Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis. BMC Cancer. 2003;3:28.
González-Pérez, A., García Rodríguez, L. A., & López-Ridaura, R. (2003). Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis. BMC Cancer, 3, 28.
González-Pérez A, García Rodríguez LA, López-Ridaura R. Effects of Non-steroidal Anti-inflammatory Drugs On Cancer Sites Other Than the Colon and Rectum: a Meta-analysis. BMC Cancer. 2003 Oct 31;3:28. PubMed PMID: 14588079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis. AU - González-Pérez,Antonio, AU - García Rodríguez,Luis A, AU - López-Ridaura,Ruy, Y1 - 2003/10/31/ PY - 2003/07/31/received PY - 2003/10/31/accepted PY - 2003/11/1/pubmed PY - 2004/5/28/medline PY - 2003/11/1/entrez SP - 28 EP - 28 JF - BMC cancer JO - BMC Cancer VL - 3 N2 - BACKGROUND: Observational studies have consistently shown that aspirin and non-steroidal anti-inflammatory drug (NSAID) use is associated with a close to 50% reduced risk of colorectal cancer. Studies assessing the effects of NSAIDs on other cancers have shown conflicting results. Therefore, we conducted a meta-analysis to evaluate the relationship between NSAID use and cancer other than colorectal. METHODS: We performed a search in Medline (from 1966 to 2002) and identified a total of 47 articles (13 cohort and 34 case-control studies). Overall estimates of the relative risk (RR) were calculated for each cancer site using random effects models. RESULTS: Aspirin use was associated with a reduced risk of cancer of the esophagus and the stomach (RR, 0.51; 95%CI (0.38-0.69), and 0.73; 95%CI (0.63-0.84)). Use of NSAIDs was similarly associated with a lower risk of esophageal and gastric cancers (RR,0.65; 95% CI(0.46-0.92) and RR,0.54; 95%CI (0.39-0.75)). Among other cancers, only the results obtained for breast cancer were fairly consistent in showing a slight reduced risk among NSAID and aspirin users (RR, 0.77; 95%CI (0.66-0.88), and RR, 0.77; 95%CI (0.69-0.86) respectively)). CONCLUSIONS: The results of this meta-analysis show that the potential chemopreventive role of NSAIDs in colorectal cancer might be extended to other gastrointestinal cancers such as esophagus and stomach. Further research is required to evaluate the role of NSAIDs at other cancers sites. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/14588079/Effects_of_non_steroidal_anti_inflammatory_drugs_on_cancer_sites_other_than_the_colon_and_rectum:_a_meta_analysis_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-3-28 DB - PRIME DP - Unbound Medicine ER -