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Effects of chloroquine on viral infections: an old drug against today's diseases?
Lancet Infect Dis. 2003 Nov; 3(11):722-7.LI

Abstract

Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor alpha and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.

Authors+Show Affiliations

Department of Infectious Diseases, Università Cattolica del Sacro Cuore, Rome, Italy. asavarino@medscape.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

14592603

Citation

Savarino, Andrea, et al. "Effects of Chloroquine On Viral Infections: an Old Drug Against Today's Diseases?" The Lancet. Infectious Diseases, vol. 3, no. 11, 2003, pp. 722-7.
Savarino A, Boelaert JR, Cassone A, et al. Effects of chloroquine on viral infections: an old drug against today's diseases? Lancet Infect Dis. 2003;3(11):722-7.
Savarino, A., Boelaert, J. R., Cassone, A., Majori, G., & Cauda, R. (2003). Effects of chloroquine on viral infections: an old drug against today's diseases? The Lancet. Infectious Diseases, 3(11), 722-7.
Savarino A, et al. Effects of Chloroquine On Viral Infections: an Old Drug Against Today's Diseases. Lancet Infect Dis. 2003;3(11):722-7. PubMed PMID: 14592603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chloroquine on viral infections: an old drug against today's diseases? AU - Savarino,Andrea, AU - Boelaert,Johan R, AU - Cassone,Antonio, AU - Majori,Giancarlo, AU - Cauda,Roberto, PY - 2003/11/1/pubmed PY - 2003/12/3/medline PY - 2003/11/1/entrez SP - 722 EP - 7 JF - The Lancet. Infectious diseases JO - Lancet Infect Dis VL - 3 IS - 11 N2 - Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor alpha and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation. SN - 1473-3099 UR - https://www.unboundmedicine.com/medline/citation/14592603/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1473309903008065 DB - PRIME DP - Unbound Medicine ER -