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Vacuolating encephalitis in mice infected by human coronavirus OC43.
Virology. 2003 Oct 10; 315(1):20-33.V

Abstract

Involvement of viruses in human neurodegenerative diseases and the underlying pathologic mechanisms remain generally unclear. Human respiratory coronaviruses (HCoV) can infect neural cells, persist in human brain, and activate myelin-reactive T cells. As a means of understanding the human infection, we characterized in vivo the neurotropic and neuroinvasive properties of HCoV-OC43 through the development of an experimental animal model. Virus inoculation of 21-day postnatal C57BL/6 and BALB/c mice led to a generalized infection of the whole CNS, demonstrating HCoV-OC43 neuroinvasiveness and neurovirulence. This acute infection targeted neurons, which underwent vacuolation and degeneration while infected regions presented strong microglial reactivity and inflammatory reactions. Damage to the CNS was not immunologically mediated and microglial reactivity was instead a consequence of direct virus-mediated neuronal injury. Although this acute encephalitis appears generally similar to that induced by murine coronaviruses, an important difference rests in the prominent spongiform-like degeneration that could trigger neuropathology in surviving animals.

Authors+Show Affiliations

Laboratory of Neuroimmunovirology, INRS-Institut Armand Frappier, 531 Boulevard des Prairies, Laval, Québec, Canada H7V 1B7.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14592756

Citation

Jacomy, Hélène, and Pierre J. Talbot. "Vacuolating Encephalitis in Mice Infected By Human Coronavirus OC43." Virology, vol. 315, no. 1, 2003, pp. 20-33.
Jacomy H, Talbot PJ. Vacuolating encephalitis in mice infected by human coronavirus OC43. Virology. 2003;315(1):20-33.
Jacomy, H., & Talbot, P. J. (2003). Vacuolating encephalitis in mice infected by human coronavirus OC43. Virology, 315(1), 20-33.
Jacomy H, Talbot PJ. Vacuolating Encephalitis in Mice Infected By Human Coronavirus OC43. Virology. 2003 Oct 10;315(1):20-33. PubMed PMID: 14592756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vacuolating encephalitis in mice infected by human coronavirus OC43. AU - Jacomy,Hélène, AU - Talbot,Pierre J, PY - 2003/11/1/pubmed PY - 2003/12/5/medline PY - 2003/11/1/entrez SP - 20 EP - 33 JF - Virology JO - Virology VL - 315 IS - 1 N2 - Involvement of viruses in human neurodegenerative diseases and the underlying pathologic mechanisms remain generally unclear. Human respiratory coronaviruses (HCoV) can infect neural cells, persist in human brain, and activate myelin-reactive T cells. As a means of understanding the human infection, we characterized in vivo the neurotropic and neuroinvasive properties of HCoV-OC43 through the development of an experimental animal model. Virus inoculation of 21-day postnatal C57BL/6 and BALB/c mice led to a generalized infection of the whole CNS, demonstrating HCoV-OC43 neuroinvasiveness and neurovirulence. This acute infection targeted neurons, which underwent vacuolation and degeneration while infected regions presented strong microglial reactivity and inflammatory reactions. Damage to the CNS was not immunologically mediated and microglial reactivity was instead a consequence of direct virus-mediated neuronal injury. Although this acute encephalitis appears generally similar to that induced by murine coronaviruses, an important difference rests in the prominent spongiform-like degeneration that could trigger neuropathology in surviving animals. SN - 0042-6822 UR - https://www.unboundmedicine.com/medline/citation/14592756/Vacuolating_encephalitis_in_mice_infected_by_human_coronavirus_OC43_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042682203003234 DB - PRIME DP - Unbound Medicine ER -