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Looking backward to move forward: early detection of neurodegenerative disorders.
Science. 2003 Oct 31; 302(5646):830-4.Sci

Abstract

Early detection of neurodegenerative disorders would provide clues to the underlying pathobiology of these diseases and would enable more effective diagnosis and treatment of patients. Recent advances in molecular neuroscience have begun to provide the tools to detect diseases like Alzheimer's disease, Parkinson's disease, and others early in their course and potentially even before the development of clinical manifestations of disease. These genetic, imaging, clinical, and biochemical tools are being validated in a number of studies. Early detection of these slowly progressive diseases offers the promise of presymptomatic diagnosis and, ultimately, of disease-modifying medications for use early in disease and during the presymptomatic period.

Authors+Show Affiliations

DeKosky ST
Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. DeKoskyST@upmc.edu
Marek K
No affiliation info available

MeSH

AgingAlzheimer DiseaseBiomarkersBrainCognition DisordersDiagnostic ImagingDopamineGenetic MarkersGenetic Predisposition to DiseaseHumansHuntington DiseaseMemoryMutationNeurodegenerative DiseasesParkinson DiseaseTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

14593169

Clinical Trial Links

A Study of the Sense of Smell in Relatives of Parkinson's Disease Patients
A Study Evaluating Potential Screening Tools for Detecting Parkinson Disease

Citation

DeKosky, Steven T., and Kenneth Marek. "Looking Backward to Move Forward: Early Detection of Neurodegenerative Disorders." Science (New York, N.Y.), vol. 302, no. 5646, 2003, pp. 830-4.
DeKosky ST, Marek K. Looking backward to move forward: early detection of neurodegenerative disorders. Science. 2003;302(5646):830-4.
DeKosky, S. T., & Marek, K. (2003). Looking backward to move forward: early detection of neurodegenerative disorders. Science (New York, N.Y.), 302(5646), 830-4.
DeKosky ST, Marek K. Looking Backward to Move Forward: Early Detection of Neurodegenerative Disorders. Science. 2003 Oct 31;302(5646):830-4. PubMed PMID: 14593169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Looking backward to move forward: early detection of neurodegenerative disorders. AU - DeKosky,Steven T, AU - Marek,Kenneth, PY - 2003/11/1/pubmed PY - 2003/12/10/medline PY - 2003/11/1/entrez SP - 830 EP - 4 JF - Science (New York, N.Y.) JO - Science VL - 302 IS - 5646 N2 - Early detection of neurodegenerative disorders would provide clues to the underlying pathobiology of these diseases and would enable more effective diagnosis and treatment of patients. Recent advances in molecular neuroscience have begun to provide the tools to detect diseases like Alzheimer's disease, Parkinson's disease, and others early in their course and potentially even before the development of clinical manifestations of disease. These genetic, imaging, clinical, and biochemical tools are being validated in a number of studies. Early detection of these slowly progressive diseases offers the promise of presymptomatic diagnosis and, ultimately, of disease-modifying medications for use early in disease and during the presymptomatic period. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/14593169/Looking_backward_to_move_forward:_early_detection_of_neurodegenerative_disorders_ DB - PRIME DP - Unbound Medicine ER -