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Chitosan microparticle preparation for controlled drug release by response surface methodology.
J Microencapsul. 2003 Nov-Dec; 20(6):791-7.JM

Abstract

The objectives were to investigate the effects of formulation variables on the release of drug and to optimize the formulation of chitosan microparticles loaded with drug for controlled release using response surface methodology. Chitosan microparticles were prepared by dropping a chitosan solution into sodium tripolyphosphate (TPP) through ionic cross-linking. The release behaviour of felodipine as a model drug was affected by preparation variables. A central composite design was used to evaluate and optimize the effect of preparation variables, chitosan concentration (X1), the pH of the TPP solution (X2) and cross-linking time (X3) on the cumulative per cent drug release (Y) in 24 h. Chitosan concentration and cross-linking time affected negatively the release of felodipine, while the pH of the TPP did so positively and was the highest influential factor. The optimum rate of drug release, 100% in 24 h, was achieved at 1.8% chitosan concentration, a pH 8.7 for the TPP solution and 9.7 min cross-linking time.

Authors+Show Affiliations

Graduate School of Biotechnology, Korea University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14594667

Citation

Ko, J A., et al. "Chitosan Microparticle Preparation for Controlled Drug Release By Response Surface Methodology." Journal of Microencapsulation, vol. 20, no. 6, 2003, pp. 791-7.
Ko JA, Park HJ, Park YS, et al. Chitosan microparticle preparation for controlled drug release by response surface methodology. J Microencapsul. 2003;20(6):791-7.
Ko, J. A., Park, H. J., Park, Y. S., Hwang, S. J., & Park, J. B. (2003). Chitosan microparticle preparation for controlled drug release by response surface methodology. Journal of Microencapsulation, 20(6), 791-7.
Ko JA, et al. Chitosan Microparticle Preparation for Controlled Drug Release By Response Surface Methodology. J Microencapsul. 2003 Nov-Dec;20(6):791-7. PubMed PMID: 14594667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitosan microparticle preparation for controlled drug release by response surface methodology. AU - Ko,J A, AU - Park,H J, AU - Park,Y S, AU - Hwang,S J, AU - Park,J B, PY - 2003/11/5/pubmed PY - 2004/2/18/medline PY - 2003/11/5/entrez SP - 791 EP - 7 JF - Journal of microencapsulation JO - J Microencapsul VL - 20 IS - 6 N2 - The objectives were to investigate the effects of formulation variables on the release of drug and to optimize the formulation of chitosan microparticles loaded with drug for controlled release using response surface methodology. Chitosan microparticles were prepared by dropping a chitosan solution into sodium tripolyphosphate (TPP) through ionic cross-linking. The release behaviour of felodipine as a model drug was affected by preparation variables. A central composite design was used to evaluate and optimize the effect of preparation variables, chitosan concentration (X1), the pH of the TPP solution (X2) and cross-linking time (X3) on the cumulative per cent drug release (Y) in 24 h. Chitosan concentration and cross-linking time affected negatively the release of felodipine, while the pH of the TPP did so positively and was the highest influential factor. The optimum rate of drug release, 100% in 24 h, was achieved at 1.8% chitosan concentration, a pH 8.7 for the TPP solution and 9.7 min cross-linking time. SN - 0265-2048 UR - https://www.unboundmedicine.com/medline/citation/14594667/Chitosan_microparticle_preparation_for_controlled_drug_release_by_response_surface_methodology_ L2 - https://www.tandfonline.com/doi/full/10.1080/02652040310001600514 DB - PRIME DP - Unbound Medicine ER -