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Antioxidant activity of extracts from Alpinia katsumadai seed.
Phytother Res. 2003 Nov; 17(9):1041-7.PR

Abstract

Alpinia katsumadai (Zingiberaceae) has been widely used in traditional Chinese medicine to treat a variety of conditions such as emesis and gastric disorders. However, very little is known about the cellular actions by which this plant mediates its therapeutic effects. Various aspects of antioxidant activity were evaluated in a total extract derived from Alpinia katsumadai seed in this study. Relatively high levels of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity were detected in the total extract (IC(50) 1.6 microgram/mL). Other known compounds such as (-)-epigallocatechine-3-gallate (EGCG) and resveratrol showed IC(50) values of <0.8 and 4.8 microgram/mL, respectively. The total extract also enhanced the viability of Chinese hamster lung fibroblast (V79-4) cells and inhibited H(2)O(2)-induced apoptosis. The total extract of Alpinia katsumadai also dose-dependently enhanced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in V79-4 cells, and these effects were comparable to other antioxidant compounds such as EGCG and resveratrol. Taken together, our findings show that Alpinia katsumadai contains significant antioxidant activity.

Authors+Show Affiliations

Department of Oral Biochemistry, College of Dentistry, Kyung Hee University Seoul 130-701, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14595584

Citation

Lee, Si Eun, et al. "Antioxidant Activity of Extracts From Alpinia Katsumadai Seed." Phytotherapy Research : PTR, vol. 17, no. 9, 2003, pp. 1041-7.
Lee SE, Shin HT, Hwang HJ, et al. Antioxidant activity of extracts from Alpinia katsumadai seed. Phytother Res. 2003;17(9):1041-7.
Lee, S. E., Shin, H. T., Hwang, H. J., & Kim, J. H. (2003). Antioxidant activity of extracts from Alpinia katsumadai seed. Phytotherapy Research : PTR, 17(9), 1041-7.
Lee SE, et al. Antioxidant Activity of Extracts From Alpinia Katsumadai Seed. Phytother Res. 2003;17(9):1041-7. PubMed PMID: 14595584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of extracts from Alpinia katsumadai seed. AU - Lee,Si Eun, AU - Shin,Hyun-Tak, AU - Hwang,Hyun Jin, AU - Kim,Jeong Hee, PY - 2003/11/5/pubmed PY - 2004/2/11/medline PY - 2003/11/5/entrez SP - 1041 EP - 7 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 9 N2 - Alpinia katsumadai (Zingiberaceae) has been widely used in traditional Chinese medicine to treat a variety of conditions such as emesis and gastric disorders. However, very little is known about the cellular actions by which this plant mediates its therapeutic effects. Various aspects of antioxidant activity were evaluated in a total extract derived from Alpinia katsumadai seed in this study. Relatively high levels of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity were detected in the total extract (IC(50) 1.6 microgram/mL). Other known compounds such as (-)-epigallocatechine-3-gallate (EGCG) and resveratrol showed IC(50) values of <0.8 and 4.8 microgram/mL, respectively. The total extract also enhanced the viability of Chinese hamster lung fibroblast (V79-4) cells and inhibited H(2)O(2)-induced apoptosis. The total extract of Alpinia katsumadai also dose-dependently enhanced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in V79-4 cells, and these effects were comparable to other antioxidant compounds such as EGCG and resveratrol. Taken together, our findings show that Alpinia katsumadai contains significant antioxidant activity. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/14595584/Antioxidant_activity_of_extracts_from_Alpinia_katsumadai_seed_ L2 - https://doi.org/10.1002/ptr.1291 DB - PRIME DP - Unbound Medicine ER -