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Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration.
Ann Neurol. 2003 Nov; 54(5):599-604.AN

Abstract

This report describes the presence of reactive microglia, the accumulation of extracellular melanin, and the extensive loss of dopaminergic neurons in the substantia nigra of monkeys administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 5 to 14 years before death. This evidence of chronic neuroinflammation years after MPTP exposure is similar to that previously reported in humans. The monkeys were drug free for at least 3 years before death, indicating that a brief exposure to MPTP had instituted an ongoing inflammatory process. The mechanism is unknown but could have important implications regarding the cause of Parkinson's disease and possible approaches to therapy.

Authors+Show Affiliations

Kinsmen Laboratory of Neurological Research, Division of Neurology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3. mcgeerpl@interchange.ubc.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14595649

Citation

McGeer, Patrick L., et al. "Presence of Reactive Microglia in Monkey Substantia Nigra Years After 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Administration." Annals of Neurology, vol. 54, no. 5, 2003, pp. 599-604.
McGeer PL, Schwab C, Parent A, et al. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Ann Neurol. 2003;54(5):599-604.
McGeer, P. L., Schwab, C., Parent, A., & Doudet, D. (2003). Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Annals of Neurology, 54(5), 599-604.
McGeer PL, et al. Presence of Reactive Microglia in Monkey Substantia Nigra Years After 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Administration. Ann Neurol. 2003;54(5):599-604. PubMed PMID: 14595649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. AU - McGeer,Patrick L, AU - Schwab,Claudia, AU - Parent,Andre, AU - Doudet,Doris, PY - 2003/11/5/pubmed PY - 2003/12/12/medline PY - 2003/11/5/entrez SP - 599 EP - 604 JF - Annals of neurology JO - Ann Neurol VL - 54 IS - 5 N2 - This report describes the presence of reactive microglia, the accumulation of extracellular melanin, and the extensive loss of dopaminergic neurons in the substantia nigra of monkeys administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 5 to 14 years before death. This evidence of chronic neuroinflammation years after MPTP exposure is similar to that previously reported in humans. The monkeys were drug free for at least 3 years before death, indicating that a brief exposure to MPTP had instituted an ongoing inflammatory process. The mechanism is unknown but could have important implications regarding the cause of Parkinson's disease and possible approaches to therapy. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/14595649/Presence_of_reactive_microglia_in_monkey_substantia_nigra_years_after_1_methyl_4_phenyl_1236_tetrahydropyridine_administration_ L2 - https://doi.org/10.1002/ana.10728 DB - PRIME DP - Unbound Medicine ER -