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Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII.
Ophthalmology. 2003 Nov; 110(11):2118-25.O

Abstract

PURPOSE

To describe the distribution of retinal vascular characteristics and their correlates in people with type 1 diabetes.

DESIGN

Population-based study with baseline cross-sectional findings.

PARTICIPANTS

Nine hundred ninety-six persons who were diagnosed with diabetes before 30 years of age and who were taking insulin in an 11-county area in south-central Wisconsin participated in the baseline examination from 1980 to 1982. In addition, 225 persons without diabetes participated.

METHODS

Retinal photographs of 7 standard fields were taken; lightbox grading was performed to determine arteriovenous (A/V) nicking and focal retinal arteriolar narrowing. Computer-assisted grading was performed from a digitized image of field 1 to determine central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and the arteriole-to-venule ratio (AVR).

MAIN OUTCOME MEASURES

Frequency and distribution of A/V nicking, CRAE, CRVE, AVR, and focal retinal arteriolar narrowing.

RESULTS

In multivariate analyses, retinopathy severity, mean arterial blood pressure, presence of gross proteinuria, glycosylated hemoglobin, and history of cardiovascular disease were associated with CRAE. Retinopathy severity, age, mean arterial blood pressure, duration of diabetes, glycosylated hemoglobin level, and body mass index were associated with CRVE. With the exception of glycosylated hemoglobin, similar factors were associated with AVR. Age (odds ratio [OR] per 10 years, 2.43 and 2.02) and retinopathy severity (OR per level, 1.14 and 1.21) were associated with focal retinal arteriolar narrowing and A/V nicking, respectively. In persons >/=18 years of age, smoking was associated with CRAE, CRVE, and A/V nicking (OR, 2.67), but not with AVR or focal arteriolar narrowing.

CONCLUSIONS

This study documented the frequency and distribution of retinal vascular characteristics and their relationships to various factors in persons with type 1 diabetes.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA. kleinr@epi.ophth.wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14597518

Citation

Klein, Ronald, et al. "Retinal Vascular Abnormalities in Persons With Type 1 Diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII." Ophthalmology, vol. 110, no. 11, 2003, pp. 2118-25.
Klein R, Klein BE, Moss SE, et al. Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII. Ophthalmology. 2003;110(11):2118-25.
Klein, R., Klein, B. E., Moss, S. E., Wong, T. Y., Hubbard, L., Cruickshanks, K. J., & Palta, M. (2003). Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII. Ophthalmology, 110(11), 2118-25.
Klein R, et al. Retinal Vascular Abnormalities in Persons With Type 1 Diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII. Ophthalmology. 2003;110(11):2118-25. PubMed PMID: 14597518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII. AU - Klein,Ronald, AU - Klein,Barbara E K, AU - Moss,Scot E, AU - Wong,Tien Y, AU - Hubbard,Larry, AU - Cruickshanks,Karen J, AU - Palta,Mari, PY - 2003/11/5/pubmed PY - 2003/12/3/medline PY - 2003/11/5/entrez SP - 2118 EP - 25 JF - Ophthalmology JO - Ophthalmology VL - 110 IS - 11 N2 - PURPOSE: To describe the distribution of retinal vascular characteristics and their correlates in people with type 1 diabetes. DESIGN: Population-based study with baseline cross-sectional findings. PARTICIPANTS: Nine hundred ninety-six persons who were diagnosed with diabetes before 30 years of age and who were taking insulin in an 11-county area in south-central Wisconsin participated in the baseline examination from 1980 to 1982. In addition, 225 persons without diabetes participated. METHODS: Retinal photographs of 7 standard fields were taken; lightbox grading was performed to determine arteriovenous (A/V) nicking and focal retinal arteriolar narrowing. Computer-assisted grading was performed from a digitized image of field 1 to determine central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and the arteriole-to-venule ratio (AVR). MAIN OUTCOME MEASURES: Frequency and distribution of A/V nicking, CRAE, CRVE, AVR, and focal retinal arteriolar narrowing. RESULTS: In multivariate analyses, retinopathy severity, mean arterial blood pressure, presence of gross proteinuria, glycosylated hemoglobin, and history of cardiovascular disease were associated with CRAE. Retinopathy severity, age, mean arterial blood pressure, duration of diabetes, glycosylated hemoglobin level, and body mass index were associated with CRVE. With the exception of glycosylated hemoglobin, similar factors were associated with AVR. Age (odds ratio [OR] per 10 years, 2.43 and 2.02) and retinopathy severity (OR per level, 1.14 and 1.21) were associated with focal retinal arteriolar narrowing and A/V nicking, respectively. In persons >/=18 years of age, smoking was associated with CRAE, CRVE, and A/V nicking (OR, 2.67), but not with AVR or focal arteriolar narrowing. CONCLUSIONS: This study documented the frequency and distribution of retinal vascular characteristics and their relationships to various factors in persons with type 1 diabetes. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/14597518/Retinal_vascular_abnormalities_in_persons_with_type_1_diabetes:_the_Wisconsin_Epidemiologic_Study_of_Diabetic_Retinopathy:_XVIII_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(03)00863-7 DB - PRIME DP - Unbound Medicine ER -