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Can we prevent Parkinson's and Alzheimer's disease?
J Postgrad Med. 2003 Jul-Sep; 49(3):236-45.JP

Abstract

Parkinson's disease (PD) and Alzheimer's (AD) are major progressive neurological disorders, the risk of which increases with advancing age (65 years and over). In familial cases, however, early onset of disease (about 35 years) is observed. In spite of extensive basic and clinical research on PD and AD, no preventive or long-term effective treatment strategies are available. Several studies have indicated that oxidative stress is a major risk factor for the initiation and progression of sporadic PD and AD. Even a-synuclein and b-amyloid fragments that are associated with the PD and AD, respectively, mediate part of their action via oxidative stress. Therefore, reducing oxidative stress appears to be a rational choice for the prevention and reduction in the rate of progression of these neurological disorders. This review provides a brief description of the epidemiology and pathogenesis of PD and AD, and the scientific rationale for the use of multiple antioxidants in the prevention of these neurological diseases.

Authors+Show Affiliations

Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA. kedar.prasad@uchsc.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

14597787

Citation

Kedar, N P.. "Can We Prevent Parkinson's and Alzheimer's Disease?" Journal of Postgraduate Medicine, vol. 49, no. 3, 2003, pp. 236-45.
Kedar NP. Can we prevent Parkinson's and Alzheimer's disease? J Postgrad Med. 2003;49(3):236-45.
Kedar, N. P. (2003). Can we prevent Parkinson's and Alzheimer's disease? Journal of Postgraduate Medicine, 49(3), 236-45.
Kedar NP. Can We Prevent Parkinson's and Alzheimer's Disease. J Postgrad Med. 2003 Jul-Sep;49(3):236-45. PubMed PMID: 14597787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can we prevent Parkinson's and Alzheimer's disease? A1 - Kedar,N P, PY - 2003/11/5/pubmed PY - 2004/2/14/medline PY - 2003/11/5/entrez SP - 236 EP - 45 JF - Journal of postgraduate medicine JO - J Postgrad Med VL - 49 IS - 3 N2 - Parkinson's disease (PD) and Alzheimer's (AD) are major progressive neurological disorders, the risk of which increases with advancing age (65 years and over). In familial cases, however, early onset of disease (about 35 years) is observed. In spite of extensive basic and clinical research on PD and AD, no preventive or long-term effective treatment strategies are available. Several studies have indicated that oxidative stress is a major risk factor for the initiation and progression of sporadic PD and AD. Even a-synuclein and b-amyloid fragments that are associated with the PD and AD, respectively, mediate part of their action via oxidative stress. Therefore, reducing oxidative stress appears to be a rational choice for the prevention and reduction in the rate of progression of these neurological disorders. This review provides a brief description of the epidemiology and pathogenesis of PD and AD, and the scientific rationale for the use of multiple antioxidants in the prevention of these neurological diseases. SN - 0022-3859 UR - https://www.unboundmedicine.com/medline/citation/14597787/Can_we_prevent_Parkinson's_and_Alzheimer's_disease L2 - http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2003;volume=49;issue=3;spage=236;epage=245;aulast=Kedar DB - PRIME DP - Unbound Medicine ER -