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Continuous apomorphine infusion and neuropsychiatric disorders: a controlled study in patients with advanced Parkinson's disease.
Neurol Sci. 2003 Oct; 24(3):174-5.NS

Abstract

The aim of this study was to assess whether patients with Parkinson's disease (PD) develop cognitive and psychiatric complications more frequently during prolonged therapy with continuous apomorphine infusion compared with standard oral treatment. Thirty consecutive PD patients with severe motor fluctuations were included in the study. Twelve patients accepted the treatment with subcutaneous continuous apomorphine infusion, while the remaining 18 preferred to continue with oral dopaminergic therapy. The two groups were evaluated with neuropsychological, psychiatric, and motor tests at baseline and after 1 year. The off daily duration and the levodopa dosage were significantly reduced in infused patients. The neuropsychiatric assessment did not change in both groups compared with baseline, except for a significant improvement of mood in the apomorphine group.

Authors+Show Affiliations

Department of Neuroscience, University of Messina, Via Consolare Valeria, Messina, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14598073

Citation

Di Rosa, A E., et al. "Continuous Apomorphine Infusion and Neuropsychiatric Disorders: a Controlled Study in Patients With Advanced Parkinson's Disease." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 24, no. 3, 2003, pp. 174-5.
Di Rosa AE, Epifanio A, Antonini A, et al. Continuous apomorphine infusion and neuropsychiatric disorders: a controlled study in patients with advanced Parkinson's disease. Neurol Sci. 2003;24(3):174-5.
Di Rosa, A. E., Epifanio, A., Antonini, A., Stocchi, F., Martino, G., Di Blasi, L., Tetto, A., Basile, G., Imbesi, D., La Spina, P., Di Raimondo, G., & Morgante, L. (2003). Continuous apomorphine infusion and neuropsychiatric disorders: a controlled study in patients with advanced Parkinson's disease. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 24(3), 174-5.
Di Rosa AE, et al. Continuous Apomorphine Infusion and Neuropsychiatric Disorders: a Controlled Study in Patients With Advanced Parkinson's Disease. Neurol Sci. 2003;24(3):174-5. PubMed PMID: 14598073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous apomorphine infusion and neuropsychiatric disorders: a controlled study in patients with advanced Parkinson's disease. AU - Di Rosa,A E, AU - Epifanio,A, AU - Antonini,A, AU - Stocchi,F, AU - Martino,G, AU - Di Blasi,L, AU - Tetto,A, AU - Basile,G, AU - Imbesi,D, AU - La Spina,P, AU - Di Raimondo,G, AU - Morgante,L, PY - 2003/11/5/pubmed PY - 2004/1/7/medline PY - 2003/11/5/entrez SP - 174 EP - 5 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 24 IS - 3 N2 - The aim of this study was to assess whether patients with Parkinson's disease (PD) develop cognitive and psychiatric complications more frequently during prolonged therapy with continuous apomorphine infusion compared with standard oral treatment. Thirty consecutive PD patients with severe motor fluctuations were included in the study. Twelve patients accepted the treatment with subcutaneous continuous apomorphine infusion, while the remaining 18 preferred to continue with oral dopaminergic therapy. The two groups were evaluated with neuropsychological, psychiatric, and motor tests at baseline and after 1 year. The off daily duration and the levodopa dosage were significantly reduced in infused patients. The neuropsychiatric assessment did not change in both groups compared with baseline, except for a significant improvement of mood in the apomorphine group. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/14598073/Continuous_apomorphine_infusion_and_neuropsychiatric_disorders:_a_controlled_study_in_patients_with_advanced_Parkinson's_disease_ L2 - https://link.springer.com/10.1007/s10072-003-0116-0 DB - PRIME DP - Unbound Medicine ER -