Tags

Type your tag names separated by a space and hit enter

Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practice.
Neurol Sci. 2003 Oct; 24(3):199-200.NS

Abstract

Measurement of total tau and amyloid beta1-42 (Ab42) in cerebrospinal fluid (CSF) improves diagnostic accuracy of Alzheimer's disease (AD). We examined a consecutive patient sample referred to our center for diagnostic assessment of cognitive decline. CSF tau and Abeta42 were assayed each week as routine neurochemical analyses. There were 119 patients investigated. These included 61 with probable AD (35 mild AD, 26 severe AD), 24 with mild cognitive impairment (MCI), 14 with vascular dementia, 11 with Lewy body dementia, and 9 with fronto-temporal dementia. Mild AD showed significantly lower CSF Abeta42 levels and significantly higher CSF tau levels than the other diagnostic groups; 79% of MCI patients had pathological values for both biomarkers. We confirm that these biomarkers have a role in the clinical work-up of patients with cognitive deficits.

Authors+Show Affiliations

Memory Clinic, Alzheimer Center, Department of Neuroscience, University of Perugia, Perugia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14598086

Citation

Parnetti, L, et al. "Cerebrospinal Fluid Biochemical Markers in Early Detection and in Differential Diagnosis of Dementia Disorders in Routine Clinical Practice." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 24, no. 3, 2003, pp. 199-200.
Parnetti L, Lanari A, Saggese E, et al. Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practice. Neurol Sci. 2003;24(3):199-200.
Parnetti, L., Lanari, A., Saggese, E., Spaccatini, C., & Gallai, V. (2003). Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practice. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 24(3), 199-200.
Parnetti L, et al. Cerebrospinal Fluid Biochemical Markers in Early Detection and in Differential Diagnosis of Dementia Disorders in Routine Clinical Practice. Neurol Sci. 2003;24(3):199-200. PubMed PMID: 14598086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practice. AU - Parnetti,L, AU - Lanari,A, AU - Saggese,E, AU - Spaccatini,C, AU - Gallai,V, PY - 2003/11/5/pubmed PY - 2004/1/7/medline PY - 2003/11/5/entrez SP - 199 EP - 200 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 24 IS - 3 N2 - Measurement of total tau and amyloid beta1-42 (Ab42) in cerebrospinal fluid (CSF) improves diagnostic accuracy of Alzheimer's disease (AD). We examined a consecutive patient sample referred to our center for diagnostic assessment of cognitive decline. CSF tau and Abeta42 were assayed each week as routine neurochemical analyses. There were 119 patients investigated. These included 61 with probable AD (35 mild AD, 26 severe AD), 24 with mild cognitive impairment (MCI), 14 with vascular dementia, 11 with Lewy body dementia, and 9 with fronto-temporal dementia. Mild AD showed significantly lower CSF Abeta42 levels and significantly higher CSF tau levels than the other diagnostic groups; 79% of MCI patients had pathological values for both biomarkers. We confirm that these biomarkers have a role in the clinical work-up of patients with cognitive deficits. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/14598086/Cerebrospinal_fluid_biochemical_markers_in_early_detection_and_in_differential_diagnosis_of_dementia_disorders_in_routine_clinical_practice_ L2 - https://link.springer.com/10.1007/s10072-003-0129-8 DB - PRIME DP - Unbound Medicine ER -