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Decreased serum level of antibody against human cytomegalovirus in patients with Behçet's disease.
Rheumatol Int. 2005 Jan; 25(1):33-6.RI

Abstract

Behçet's disease (BD) is a connective tissue disorder characterized by recurrent orogenital ulcer, uveitis, and skin lesions. Recurrent aphthous ulcer is associated with human cytomegalovirus (HCMV). To investigate the possible role of HCMV in BD, we measured the titers of IgG, IgM, and IgA anti-HCMV antibodies in 73 Korean patients with BD, 50 with scleroderma, 70 with systemic lupus erythematosus, and 50 from healthy controls by indirect immunofluorescent staining. The titer of IgG anti-HCMV antibody was significantly lower in patients with BD than in controls (geometric mean 3115.4 vs 9687.6, P = 0.0001 by Wilcoxon's rank sum test), as was the titer of IgA anti-HCMV antibody (geometric mean 1.9 vs 15.7, P = 0.0001, Wilcoxon's rank sum test). In conclusion, we found significantly lower antibody responses to HCMV in patients with BD.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University College of Medicine, Yongon-dong, Chongno-gu, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14600786

Citation

Lee, Eun Bong, et al. "Decreased Serum Level of Antibody Against Human Cytomegalovirus in Patients With Behçet's Disease." Rheumatology International, vol. 25, no. 1, 2005, pp. 33-6.
Lee EB, Kwon YJ, Shin KC, et al. Decreased serum level of antibody against human cytomegalovirus in patients with Behçet's disease. Rheumatol Int. 2005;25(1):33-6.
Lee, E. B., Kwon, Y. J., Shin, K. C., Song, Y. W., Park, C. G., Hwang, E. S., & Cha, C. Y. (2005). Decreased serum level of antibody against human cytomegalovirus in patients with Behçet's disease. Rheumatology International, 25(1), 33-6.
Lee EB, et al. Decreased Serum Level of Antibody Against Human Cytomegalovirus in Patients With Behçet's Disease. Rheumatol Int. 2005;25(1):33-6. PubMed PMID: 14600786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased serum level of antibody against human cytomegalovirus in patients with Behçet's disease. AU - Lee,Eun Bong, AU - Kwon,Ye Jin, AU - Shin,Ki Chul, AU - Song,Yeong Wook, AU - Park,Chung-Gyu, AU - Hwang,Eung-Soo, AU - Cha,Chang-Yong, Y1 - 2003/11/05/ PY - 2003/03/11/received PY - 2003/08/19/accepted PY - 2003/11/6/pubmed PY - 2005/7/6/medline PY - 2003/11/6/entrez SP - 33 EP - 6 JF - Rheumatology international JO - Rheumatol. Int. VL - 25 IS - 1 N2 - Behçet's disease (BD) is a connective tissue disorder characterized by recurrent orogenital ulcer, uveitis, and skin lesions. Recurrent aphthous ulcer is associated with human cytomegalovirus (HCMV). To investigate the possible role of HCMV in BD, we measured the titers of IgG, IgM, and IgA anti-HCMV antibodies in 73 Korean patients with BD, 50 with scleroderma, 70 with systemic lupus erythematosus, and 50 from healthy controls by indirect immunofluorescent staining. The titer of IgG anti-HCMV antibody was significantly lower in patients with BD than in controls (geometric mean 3115.4 vs 9687.6, P = 0.0001 by Wilcoxon's rank sum test), as was the titer of IgA anti-HCMV antibody (geometric mean 1.9 vs 15.7, P = 0.0001, Wilcoxon's rank sum test). In conclusion, we found significantly lower antibody responses to HCMV in patients with BD. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/14600786/Decreased_serum_level_of_antibody_against_human_cytomegalovirus_in_patients_with_Behçet's_disease_ L2 - https://dx.doi.org/10.1007/s00296-003-0394-0 DB - PRIME DP - Unbound Medicine ER -