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Why there is no cookbook approach to palliative care: implications of the P450 enzyme system.
Clin J Oncol Nurs. 2003 Sep-Oct; 7(5):569-72.CJ

Abstract

A plethora of literature describes the impact of the P450 enzyme system, but this information is limited regarding its relevancy to nursing practice. However, oncology nurses providing palliative symptom management must have a working knowledge of the P450 enzyme system to recognize the variability that exists among individual medication reactions or why a "cookbook approach" to symptom management is not always effective and appropriate. This article describes the variations associated with medication metabolism with reference to ethnic differences. Having a basic understanding of the P450 enzyme system and, more specifically, the CYP2D6 influence on the metabolism of common medications used in palliative symptom management can help to prevent medication toxicity or underdosing, which interferes with patients' quality of life.

Authors+Show Affiliations

kim_kuebler@emoryhealthcare.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14603555

Citation

Kuebler, Kim K., et al. "Why There Is No Cookbook Approach to Palliative Care: Implications of the P450 Enzyme System." Clinical Journal of Oncology Nursing, vol. 7, no. 5, 2003, pp. 569-72.
Kuebler KK, Varga J, Mihelic RA. Why there is no cookbook approach to palliative care: implications of the P450 enzyme system. Clin J Oncol Nurs. 2003;7(5):569-72.
Kuebler, K. K., Varga, J., & Mihelic, R. A. (2003). Why there is no cookbook approach to palliative care: implications of the P450 enzyme system. Clinical Journal of Oncology Nursing, 7(5), 569-72.
Kuebler KK, Varga J, Mihelic RA. Why There Is No Cookbook Approach to Palliative Care: Implications of the P450 Enzyme System. Clin J Oncol Nurs. 2003 Sep-Oct;7(5):569-72. PubMed PMID: 14603555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Why there is no cookbook approach to palliative care: implications of the P450 enzyme system. AU - Kuebler,Kim K, AU - Varga,James, AU - Mihelic,Ronald A, PY - 2003/11/8/pubmed PY - 2003/12/12/medline PY - 2003/11/8/entrez SP - 569 EP - 72 JF - Clinical journal of oncology nursing JO - Clin J Oncol Nurs VL - 7 IS - 5 N2 - A plethora of literature describes the impact of the P450 enzyme system, but this information is limited regarding its relevancy to nursing practice. However, oncology nurses providing palliative symptom management must have a working knowledge of the P450 enzyme system to recognize the variability that exists among individual medication reactions or why a "cookbook approach" to symptom management is not always effective and appropriate. This article describes the variations associated with medication metabolism with reference to ethnic differences. Having a basic understanding of the P450 enzyme system and, more specifically, the CYP2D6 influence on the metabolism of common medications used in palliative symptom management can help to prevent medication toxicity or underdosing, which interferes with patients' quality of life. SN - 1092-1095 UR - https://www.unboundmedicine.com/medline/citation/14603555/Why_there_is_no_cookbook_approach_to_palliative_care:_implications_of_the_P450_enzyme_system L2 - http://store.ons.org/article/find?doi=10.1188/03.CJON.569-572 DB - PRIME DP - Unbound Medicine ER -