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Effects of surface roughness and chrome plating of punch tips on the sticking tendencies of model ibuprofen formulations.
J Pharm Pharmacol. 2003 Sep; 55(9):1223-8.JP

Abstract

The sticking of three model ibuprofen-lactose formulations with respect to compaction force and the surface quality of the upper punch were assessed. Compaction was performed at 10, 25 or 40 kN using an instrumented single-punch tablet press. Two sets of 12.5-mm flat-faced punches were used to evaluate the influence of surface quality. A third set of chrome-plated tooling was also used. Surface profiles (Taylor Hobson Talysurf 120) of the normal tooling upper punches indicated a large difference in quality. The punches were subsequently classified as old (Ra = 0.33 microm) or new (Ra = 0.04 microm) where Ra is the mean of all positive deviations from zero. Surface profiles of sample tablets were also obtained. Following compaction, ibuprofen attached to the face was quantified by spectroscopy. Punch surface roughness, compaction force and the blend composition were all significant factors contributing to sticking. Chrome plating of punch faces increased sticking at a low compaction force but decreased sticking at higher forces. Surface roughness of the tablets did not correlate with the corresponding data for sticking, indicating that this is not a suitable method of quantifying sticking.

Authors+Show Affiliations

School of Pharmacy and Chemistry, Liverpool John Moores University, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14604465

Citation

Roberts, Matthew, et al. "Effects of Surface Roughness and Chrome Plating of Punch Tips On the Sticking Tendencies of Model Ibuprofen Formulations." The Journal of Pharmacy and Pharmacology, vol. 55, no. 9, 2003, pp. 1223-8.
Roberts M, Ford JL, MacLeod GS, et al. Effects of surface roughness and chrome plating of punch tips on the sticking tendencies of model ibuprofen formulations. J Pharm Pharmacol. 2003;55(9):1223-8.
Roberts, M., Ford, J. L., MacLeod, G. S., Fell, J. T., Smith, G. W., & Rowe, P. H. (2003). Effects of surface roughness and chrome plating of punch tips on the sticking tendencies of model ibuprofen formulations. The Journal of Pharmacy and Pharmacology, 55(9), 1223-8.
Roberts M, et al. Effects of Surface Roughness and Chrome Plating of Punch Tips On the Sticking Tendencies of Model Ibuprofen Formulations. J Pharm Pharmacol. 2003;55(9):1223-8. PubMed PMID: 14604465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of surface roughness and chrome plating of punch tips on the sticking tendencies of model ibuprofen formulations. AU - Roberts,Matthew, AU - Ford,James L, AU - MacLeod,Graeme S, AU - Fell,John T, AU - Smith,George W, AU - Rowe,Philip H, PY - 2003/11/8/pubmed PY - 2006/6/14/medline PY - 2003/11/8/entrez SP - 1223 EP - 8 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 55 IS - 9 N2 - The sticking of three model ibuprofen-lactose formulations with respect to compaction force and the surface quality of the upper punch were assessed. Compaction was performed at 10, 25 or 40 kN using an instrumented single-punch tablet press. Two sets of 12.5-mm flat-faced punches were used to evaluate the influence of surface quality. A third set of chrome-plated tooling was also used. Surface profiles (Taylor Hobson Talysurf 120) of the normal tooling upper punches indicated a large difference in quality. The punches were subsequently classified as old (Ra = 0.33 microm) or new (Ra = 0.04 microm) where Ra is the mean of all positive deviations from zero. Surface profiles of sample tablets were also obtained. Following compaction, ibuprofen attached to the face was quantified by spectroscopy. Punch surface roughness, compaction force and the blend composition were all significant factors contributing to sticking. Chrome plating of punch faces increased sticking at a low compaction force but decreased sticking at higher forces. Surface roughness of the tablets did not correlate with the corresponding data for sticking, indicating that this is not a suitable method of quantifying sticking. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/14604465/Effects_of_surface_roughness_and_chrome_plating_of_punch_tips_on_the_sticking_tendencies_of_model_ibuprofen_formulations_ L2 - https://academic.oup.com/jpp/article-lookup/doi/10.1211/0022357021684 DB - PRIME DP - Unbound Medicine ER -