Tags

Type your tag names separated by a space and hit enter

BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures.
J Bone Miner Res. 2003 Nov; 18(11):1947-54.JB

Abstract

In a large cohort of U.S. women aged 65 and older, we report the relationships of BMD measured at several sites, and subsequent fracture risk at multiple sites over > 8 years of follow-up. Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest.

INTRODUCTION

Although several studies have reported the relationship between bone mineral density (BMD) and subsequent fracture risk, most have been limited by short follow-up time, BMD measures at only one or two sites, or availability of data for only select fracture types.

MATERIALS AND METHODS

In the multicenter Study of Osteoporotic Fractures (SOF), we studied the relationship of several different BMD measures to fracture risk of multiple types in 9704 non-black women aged 65 and older. We previously reported on the relationship of peripheral BMD measures to risk of several types of fracture during an average 2.2-year follow-up period. In this expanded analysis, we present results of the relationship of both peripheral and central BMD measures and fractures of multiple types during 10.4 and 8.5 years of follow-up, respectively. We also report population attributable risk (PAR) estimates for osteoporosis and risk of several types of fracture.

RESULTS

Our results show that almost all types of fractures have an increased incidence in women with low BMD. However, hip BMD is somewhat more strongly related to most of the fracture types studied than spine or peripheral BMD measures. Nonetheless, the proportion of fractures attributable to osteoporosis (based on a standard definition of osteoporosis) is modest, ranging from < 10% to 44% based on the most commonly used definition of osteoporosis (BMD T-score < -2.5).

CONCLUSION

Finding effective prevention strategies for fractures in older women will require additional interventions beside preventions for bone loss, such as prevention of falls and other fracture risk factors.

Authors+Show Affiliations

Department of Medicine, University of California, San Francisco, California 94105, USA. kstone@psg.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14606506

Citation

Stone, Katie L., et al. "BMD at Multiple Sites and Risk of Fracture of Multiple Types: Long-term Results From the Study of Osteoporotic Fractures." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 18, no. 11, 2003, pp. 1947-54.
Stone KL, Seeley DG, Lui LY, et al. BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res. 2003;18(11):1947-54.
Stone, K. L., Seeley, D. G., Lui, L. Y., Cauley, J. A., Ensrud, K., Browner, W. S., Nevitt, M. C., & Cummings, S. R. (2003). BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 18(11), 1947-54.
Stone KL, et al. BMD at Multiple Sites and Risk of Fracture of Multiple Types: Long-term Results From the Study of Osteoporotic Fractures. J Bone Miner Res. 2003;18(11):1947-54. PubMed PMID: 14606506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. AU - Stone,Katie L, AU - Seeley,Dana G, AU - Lui,Li-Yung, AU - Cauley,Jane A, AU - Ensrud,Kristine, AU - Browner,Warren S, AU - Nevitt,Michael C, AU - Cummings,Steven R, AU - ,, PY - 2003/11/11/pubmed PY - 2004/6/26/medline PY - 2003/11/11/entrez SP - 1947 EP - 54 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 18 IS - 11 N2 - UNLABELLED: In a large cohort of U.S. women aged 65 and older, we report the relationships of BMD measured at several sites, and subsequent fracture risk at multiple sites over > 8 years of follow-up. Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest. INTRODUCTION: Although several studies have reported the relationship between bone mineral density (BMD) and subsequent fracture risk, most have been limited by short follow-up time, BMD measures at only one or two sites, or availability of data for only select fracture types. MATERIALS AND METHODS: In the multicenter Study of Osteoporotic Fractures (SOF), we studied the relationship of several different BMD measures to fracture risk of multiple types in 9704 non-black women aged 65 and older. We previously reported on the relationship of peripheral BMD measures to risk of several types of fracture during an average 2.2-year follow-up period. In this expanded analysis, we present results of the relationship of both peripheral and central BMD measures and fractures of multiple types during 10.4 and 8.5 years of follow-up, respectively. We also report population attributable risk (PAR) estimates for osteoporosis and risk of several types of fracture. RESULTS: Our results show that almost all types of fractures have an increased incidence in women with low BMD. However, hip BMD is somewhat more strongly related to most of the fracture types studied than spine or peripheral BMD measures. Nonetheless, the proportion of fractures attributable to osteoporosis (based on a standard definition of osteoporosis) is modest, ranging from < 10% to 44% based on the most commonly used definition of osteoporosis (BMD T-score < -2.5). CONCLUSION: Finding effective prevention strategies for fractures in older women will require additional interventions beside preventions for bone loss, such as prevention of falls and other fracture risk factors. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/14606506/BMD_at_multiple_sites_and_risk_of_fracture_of_multiple_types:_long_term_results_from_the_Study_of_Osteoporotic_Fractures_ L2 - https://doi.org/10.1359/jbmr.2003.18.11.1947 DB - PRIME DP - Unbound Medicine ER -