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Performance characteristics of selected immunoassays for preliminary test of 3,4-methylenedioxymethamphetamine, methamphetamine, and related drugs in urine specimens.
J Anal Toxicol 2003; 27(7):471-8JA

Abstract

Eight commercially available immunoassays for amphetamines (DRI Amphetamines, CEDIA DAU Amphetamines-Semiquantitative, EMIT d.a.u. Monoclonal Amphetamine/Methamphetamine, Synchron CX Systems AMPH, TDx/TDxFLx Amphetamine/Methamphetamine II, CEDIA Amphetamines/Ecstasy, COBAS INTEGRA Amphetamines, and Abuscreen((R)) OnLine HS Amphetamine/MDMA) are evaluated for their effectiveness in serving as the preliminary test methodology for the analysis of 3,4-methylenedioxymethamphetamine/3,4-methylenedioxyamphetamine (MDMA/MDA) and methamphetamine/amphetamine (MA/AM). Standard solutions (in urine matrix) of MDMA, MDA, MA, and AM are used to determine these immunoassays' reactivities (or cross-reactivities) toward these compounds of interest. Case specimens containing MDMA/MDA and MA/AM are also used to study the correlations of the apparent immunoassay MDMA (or MA) concentrations and the gas chromatographic-mass spectrometric concentrations of these compounds. Data resulting from this study suggest that CEDIA Amphetamines/Ecstasy can best predict the concentrations of MDMA and MA in case specimens and can also detect the presence of MDMA at low levels, whereas Abuscreen OnLine HS Amphetamine/MDMA can detect both MDMA and MA at low concentrations.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Hsu J
    National Bureau of Controlled Drugs, Department of Health, Taipei, Taiwan.
    Liu C
    No affiliation info available
    Liu CP
    No affiliation info available
    Tsay WI
    No affiliation info available
    Li JH
    No affiliation info available
    Lin DL
    No affiliation info available
    Liu RH
    No affiliation info available

    MeSH

    Gas Chromatography-Mass SpectrometryHumansImmunoassayMethamphetamineN-Methyl-3,4-methylenedioxyamphetamineReference StandardsSensitivity and SpecificitySpecimen HandlingSubstance Abuse Detection

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14607002

    Citation

    Hsu, Jui, et al. "Performance Characteristics of Selected Immunoassays for Preliminary Test of 3,4-methylenedioxymethamphetamine, Methamphetamine, and Related Drugs in Urine Specimens." Journal of Analytical Toxicology, vol. 27, no. 7, 2003, pp. 471-8.
    Hsu J, Liu C, Liu CP, et al. Performance characteristics of selected immunoassays for preliminary test of 3,4-methylenedioxymethamphetamine, methamphetamine, and related drugs in urine specimens. J Anal Toxicol. 2003;27(7):471-8.
    Hsu, J., Liu, C., Liu, C. P., Tsay, W. I., Li, J. H., Lin, D. L., & Liu, R. H. (2003). Performance characteristics of selected immunoassays for preliminary test of 3,4-methylenedioxymethamphetamine, methamphetamine, and related drugs in urine specimens. Journal of Analytical Toxicology, 27(7), pp. 471-8.
    Hsu J, et al. Performance Characteristics of Selected Immunoassays for Preliminary Test of 3,4-methylenedioxymethamphetamine, Methamphetamine, and Related Drugs in Urine Specimens. J Anal Toxicol. 2003;27(7):471-8. PubMed PMID: 14607002.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Performance characteristics of selected immunoassays for preliminary test of 3,4-methylenedioxymethamphetamine, methamphetamine, and related drugs in urine specimens. AU - Hsu,Jui, AU - Liu,Chiareiy, AU - Liu,C P, AU - Tsay,Wen-Ing, AU - Li,Jih-Heng, AU - Lin,Dong-Liang, AU - Liu,Ray H, PY - 2003/11/11/pubmed PY - 2004/7/17/medline PY - 2003/11/11/entrez SP - 471 EP - 8 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 27 IS - 7 N2 - Eight commercially available immunoassays for amphetamines (DRI Amphetamines, CEDIA DAU Amphetamines-Semiquantitative, EMIT d.a.u. Monoclonal Amphetamine/Methamphetamine, Synchron CX Systems AMPH, TDx/TDxFLx Amphetamine/Methamphetamine II, CEDIA Amphetamines/Ecstasy, COBAS INTEGRA Amphetamines, and Abuscreen((R)) OnLine HS Amphetamine/MDMA) are evaluated for their effectiveness in serving as the preliminary test methodology for the analysis of 3,4-methylenedioxymethamphetamine/3,4-methylenedioxyamphetamine (MDMA/MDA) and methamphetamine/amphetamine (MA/AM). Standard solutions (in urine matrix) of MDMA, MDA, MA, and AM are used to determine these immunoassays' reactivities (or cross-reactivities) toward these compounds of interest. Case specimens containing MDMA/MDA and MA/AM are also used to study the correlations of the apparent immunoassay MDMA (or MA) concentrations and the gas chromatographic-mass spectrometric concentrations of these compounds. Data resulting from this study suggest that CEDIA Amphetamines/Ecstasy can best predict the concentrations of MDMA and MA in case specimens and can also detect the presence of MDMA at low levels, whereas Abuscreen OnLine HS Amphetamine/MDMA can detect both MDMA and MA at low concentrations. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/14607002/Performance_characteristics_of_selected_immunoassays_for_preliminary_test_of_34_methylenedioxymethamphetamine_methamphetamine_and_related_drugs_in_urine_specimens_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/27.7.471 DB - PRIME DP - Unbound Medicine ER -
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