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Accessibility of solid core tablet for dissolution in an asymmetric triple-layer matrix system.
J Pharm Pharmacol. 2003 Oct; 55(10):1331-7.JP

Abstract

The importance of glassy matrix surface area to ensure constant drug release and the effect of barrier layer thickness on the duration of linear release in an asymmetric triple-layer tablet with zero-order release kinetics were investigated. Poly(ethylene oxide) of different molecular weights and hydroxypropylmethylcellulose K4M were the major polymeric constituents, and verapamil hydrochloride was used as a drug model. The contribution of diffusion and polymer relaxation towards drug release was evaluated based on drug release data using a non-linear regression analysis algorithm. The results demonstrated that application of barrier layers to the central core tablet enables polymer relaxation to be the predominant mechanism in controlling drug release and leads to the often desired zero-order release kinetics. The duration of linear release from the asymmetric triple-layer tablet depends on the barrier layer thickness and composition. It was further indicated that the magnitude of diffusion and polymer relaxation in controlling drug release is affected by the accessibility of the drug core tablet for dissolution, as well as the inherent swelling and erosion characteristics of the release rate-controlling polymer.

Authors+Show Affiliations

Yang L
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140, USA. lyang@icos.com
Fassihi R
No affiliation info available

MeSH

Administration, OralCalcium Channel BlockersChemistry, PharmaceuticalDelayed-Action PreparationsDiffusionHypromellose DerivativesKineticsMethylcelluloseMolecular WeightPolyethylene GlycolsProtease InhibitorsSolubilityTabletsVerapamil

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14607013

Citation

Yang, Libo, and Reza Fassihi. "Accessibility of Solid Core Tablet for Dissolution in an Asymmetric Triple-layer Matrix System." The Journal of Pharmacy and Pharmacology, vol. 55, no. 10, 2003, pp. 1331-7.
Yang L, Fassihi R. Accessibility of solid core tablet for dissolution in an asymmetric triple-layer matrix system. J Pharm Pharmacol. 2003;55(10):1331-7.
Yang, L., & Fassihi, R. (2003). Accessibility of solid core tablet for dissolution in an asymmetric triple-layer matrix system. The Journal of Pharmacy and Pharmacology, 55(10), 1331-7.
Yang L, Fassihi R. Accessibility of Solid Core Tablet for Dissolution in an Asymmetric Triple-layer Matrix System. J Pharm Pharmacol. 2003;55(10):1331-7. PubMed PMID: 14607013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accessibility of solid core tablet for dissolution in an asymmetric triple-layer matrix system. AU - Yang,Libo, AU - Fassihi,Reza, PY - 2003/11/11/pubmed PY - 2004/2/11/medline PY - 2003/11/11/entrez SP - 1331 EP - 7 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 55 IS - 10 N2 - The importance of glassy matrix surface area to ensure constant drug release and the effect of barrier layer thickness on the duration of linear release in an asymmetric triple-layer tablet with zero-order release kinetics were investigated. Poly(ethylene oxide) of different molecular weights and hydroxypropylmethylcellulose K4M were the major polymeric constituents, and verapamil hydrochloride was used as a drug model. The contribution of diffusion and polymer relaxation towards drug release was evaluated based on drug release data using a non-linear regression analysis algorithm. The results demonstrated that application of barrier layers to the central core tablet enables polymer relaxation to be the predominant mechanism in controlling drug release and leads to the often desired zero-order release kinetics. The duration of linear release from the asymmetric triple-layer tablet depends on the barrier layer thickness and composition. It was further indicated that the magnitude of diffusion and polymer relaxation in controlling drug release is affected by the accessibility of the drug core tablet for dissolution, as well as the inherent swelling and erosion characteristics of the release rate-controlling polymer. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/14607013/Accessibility_of_solid_core_tablet_for_dissolution_in_an_asymmetric_triple_layer_matrix_system_ DB - PRIME DP - Unbound Medicine ER -