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Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects.
Cancer Lett. 2003 Nov 25; 201(2):133-7.CL

Abstract

From an ethyl acetate-soluble fraction of the exudate obtained from the stems of Angelica keiskei (Umbelliferae), 17 compounds, viz. five chalcones (1-5), seven coumarins (6-12), three flavanones (13-15), one diacetylene (16), and one 5-alkylresorcinol (17), were isolated. These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor-promoters. With the exception of three compounds (10, 16, and 17), all other compounds tested showed potent inhibitory effects on EBV-EA induction (92-100% inhibition at 1x10(3)mol ratio/TPA). In addition, upon evaluation of these compounds for the inhibitory effects against activation of (+/-)-(E)-methyl-2-[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for antitumor-initiators, two chalcones (2 and 3) and six coumarins (6-11) exhibited potent inhibitory effects.

Authors+Show Affiliations

College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan. akihisa@chem.cst.nihon-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14607326

Citation

Akihisa, Toshihiro, et al. "Chalcones, Coumarins, and Flavanones From the Exudate of Angelica Keiskei and Their Chemopreventive Effects." Cancer Letters, vol. 201, no. 2, 2003, pp. 133-7.
Akihisa T, Tokuda H, Ukiya M, et al. Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects. Cancer Lett. 2003;201(2):133-7.
Akihisa, T., Tokuda, H., Ukiya, M., Iizuka, M., Schneider, S., Ogasawara, K., Mukainaka, T., Iwatsuki, K., Suzuki, T., & Nishino, H. (2003). Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects. Cancer Letters, 201(2), 133-7.
Akihisa T, et al. Chalcones, Coumarins, and Flavanones From the Exudate of Angelica Keiskei and Their Chemopreventive Effects. Cancer Lett. 2003 Nov 25;201(2):133-7. PubMed PMID: 14607326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects. AU - Akihisa,Toshihiro, AU - Tokuda,Harukuni, AU - Ukiya,Motohiko, AU - Iizuka,Masao, AU - Schneider,Stefan, AU - Ogasawara,Kazuya, AU - Mukainaka,Teruo, AU - Iwatsuki,Kenji, AU - Suzuki,Takashi, AU - Nishino,Hoyoku, PY - 2003/11/11/pubmed PY - 2004/1/6/medline PY - 2003/11/11/entrez SP - 133 EP - 7 JF - Cancer letters JO - Cancer Lett. VL - 201 IS - 2 N2 - From an ethyl acetate-soluble fraction of the exudate obtained from the stems of Angelica keiskei (Umbelliferae), 17 compounds, viz. five chalcones (1-5), seven coumarins (6-12), three flavanones (13-15), one diacetylene (16), and one 5-alkylresorcinol (17), were isolated. These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor-promoters. With the exception of three compounds (10, 16, and 17), all other compounds tested showed potent inhibitory effects on EBV-EA induction (92-100% inhibition at 1x10(3)mol ratio/TPA). In addition, upon evaluation of these compounds for the inhibitory effects against activation of (+/-)-(E)-methyl-2-[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for antitumor-initiators, two chalcones (2 and 3) and six coumarins (6-11) exhibited potent inhibitory effects. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/14607326/Chalcones_coumarins_and_flavanones_from_the_exudate_of_Angelica_keiskei_and_their_chemopreventive_effects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S030438350300466X DB - PRIME DP - Unbound Medicine ER -