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Morphological analysis of the hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN1) immunoreactive bipolar cells in the rabbit retina.
J Comp Neurol. 2003 Dec 15; 467(3):389-402.JC

Abstract

Hyperpolarization-activated cation currents (I(h)) have been identified in neurons in the central nervous system, including the retina. There is growing evidence that these currents, mediated by the hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN), may play important roles in visual processing in the retina. This study was conducted to identify and characterize HCN1-immunoreactive (IR) bipolar cells by immunocytochemistry, quantitative analysis, and electron microscopy. The HCN1-IR bipolar cells were a subtype of OFF-type cone bipolar cells and comprised 10% of the total number of cone bipolar cells. The axons of the HCN1-IR cone bipolar cells ramified narrowly in the border of strata 1 and 2 of the inner plexiform layer (IPL). These cells formed a regular distribution, with a density of 1,825 cells/mm(2) at a position 1 mm ventral to the visual streak, falling to 650 cells/mm(2) in the ventral periphery. Double-labeling experiments demonstrated that their axons stratified narrowly within and slightly proximal to the OFF-starburst amacrine cell processes. In the IPL, they were presynaptic to amacrine cell processes. The most frequent postsynaptic dyads formed of HCN1-IR bipolar cell axon terminals are pairs composed of both amacrine cell processes. These results suggest that these HCN1-IR cone bipolar cells might be the same as the DAPI-Ba1 bipolar population, and might therefore be involved in a direction-selective mechanism, providing inputs to the OFF-starburst amacrine cells and/or the OFF-plexus of the ON-OFF ganglion cells.

Authors+Show Affiliations

Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14608601

Citation

Kim, In-Beom, et al. "Morphological Analysis of the Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel 1 (HCN1) Immunoreactive Bipolar Cells in the Rabbit Retina." The Journal of Comparative Neurology, vol. 467, no. 3, 2003, pp. 389-402.
Kim IB, Lee EJ, Kang TH, et al. Morphological analysis of the hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN1) immunoreactive bipolar cells in the rabbit retina. J Comp Neurol. 2003;467(3):389-402.
Kim, I. B., Lee, E. J., Kang, T. H., Chung, J. W., & Chun, M. H. (2003). Morphological analysis of the hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN1) immunoreactive bipolar cells in the rabbit retina. The Journal of Comparative Neurology, 467(3), 389-402.
Kim IB, et al. Morphological Analysis of the Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel 1 (HCN1) Immunoreactive Bipolar Cells in the Rabbit Retina. J Comp Neurol. 2003 Dec 15;467(3):389-402. PubMed PMID: 14608601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphological analysis of the hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN1) immunoreactive bipolar cells in the rabbit retina. AU - Kim,In-Beom, AU - Lee,Eun-Jin, AU - Kang,Tae-Hoon, AU - Chung,Jin-Woong, AU - Chun,Myung-Hoon, PY - 2003/11/11/pubmed PY - 2004/1/24/medline PY - 2003/11/11/entrez SP - 389 EP - 402 JF - The Journal of comparative neurology JO - J. Comp. Neurol. VL - 467 IS - 3 N2 - Hyperpolarization-activated cation currents (I(h)) have been identified in neurons in the central nervous system, including the retina. There is growing evidence that these currents, mediated by the hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN), may play important roles in visual processing in the retina. This study was conducted to identify and characterize HCN1-immunoreactive (IR) bipolar cells by immunocytochemistry, quantitative analysis, and electron microscopy. The HCN1-IR bipolar cells were a subtype of OFF-type cone bipolar cells and comprised 10% of the total number of cone bipolar cells. The axons of the HCN1-IR cone bipolar cells ramified narrowly in the border of strata 1 and 2 of the inner plexiform layer (IPL). These cells formed a regular distribution, with a density of 1,825 cells/mm(2) at a position 1 mm ventral to the visual streak, falling to 650 cells/mm(2) in the ventral periphery. Double-labeling experiments demonstrated that their axons stratified narrowly within and slightly proximal to the OFF-starburst amacrine cell processes. In the IPL, they were presynaptic to amacrine cell processes. The most frequent postsynaptic dyads formed of HCN1-IR bipolar cell axon terminals are pairs composed of both amacrine cell processes. These results suggest that these HCN1-IR cone bipolar cells might be the same as the DAPI-Ba1 bipolar population, and might therefore be involved in a direction-selective mechanism, providing inputs to the OFF-starburst amacrine cells and/or the OFF-plexus of the ON-OFF ganglion cells. SN - 0021-9967 UR - https://www.unboundmedicine.com/medline/citation/14608601/Morphological_analysis_of_the_hyperpolarization_activated_cyclic_nucleotide_gated_cation_channel_1__HCN1__immunoreactive_bipolar_cells_in_the_rabbit_retina_ L2 - https://doi.org/10.1002/cne.10957 DB - PRIME DP - Unbound Medicine ER -