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A high-performance matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometer with collisional cooling.
Rapid Commun Mass Spectrom. 2003; 17(22):2508-16.RC

Abstract

A high-performance orthogonal time-of-flight (TOF) mass spectrometer was developed specifically for use in combination with a matrix-assisted laser desorption/ionization (MALDI) source. The MALDI source features an ionization region containing a buffer gas with variable pressure. The source is interfaced to the TOF section via a collisional focusing ion guide. The pressure in the source influences the rate of cooling and allows control of ion fragmentation. The instrument provides uniform resolution up to 18,000 FWHM (full width at half maximum). Mass accuracy routinely achieved with a single-point internal recalibration is below 2 ppm for protein digest samples. The instrument is also capable of recording spectra of samples containing compounds with a broad range of masses while using one set of experimental conditions and without compromising resolution or mass accuracy.

Authors+Show Affiliations

MDS SCIEX, 71 Four Valley Drive, Concord, Ontario L4K 4V8, Canada. lobodaav@sciex.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14608621

Citation

Loboda, A V., et al. "A High-performance Matrix-assisted Laser Desorption/ionization Orthogonal Time-of-flight Mass Spectrometer With Collisional Cooling." Rapid Communications in Mass Spectrometry : RCM, vol. 17, no. 22, 2003, pp. 2508-16.
Loboda AV, Ackloo S, Chernushevich IV. A high-performance matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometer with collisional cooling. Rapid Commun Mass Spectrom. 2003;17(22):2508-16.
Loboda, A. V., Ackloo, S., & Chernushevich, I. V. (2003). A high-performance matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometer with collisional cooling. Rapid Communications in Mass Spectrometry : RCM, 17(22), 2508-16.
Loboda AV, Ackloo S, Chernushevich IV. A High-performance Matrix-assisted Laser Desorption/ionization Orthogonal Time-of-flight Mass Spectrometer With Collisional Cooling. Rapid Commun Mass Spectrom. 2003;17(22):2508-16. PubMed PMID: 14608621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A high-performance matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometer with collisional cooling. AU - Loboda,A V, AU - Ackloo,S, AU - Chernushevich,I V, PY - 2003/11/11/pubmed PY - 2004/1/13/medline PY - 2003/11/11/entrez SP - 2508 EP - 16 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 17 IS - 22 N2 - A high-performance orthogonal time-of-flight (TOF) mass spectrometer was developed specifically for use in combination with a matrix-assisted laser desorption/ionization (MALDI) source. The MALDI source features an ionization region containing a buffer gas with variable pressure. The source is interfaced to the TOF section via a collisional focusing ion guide. The pressure in the source influences the rate of cooling and allows control of ion fragmentation. The instrument provides uniform resolution up to 18,000 FWHM (full width at half maximum). Mass accuracy routinely achieved with a single-point internal recalibration is below 2 ppm for protein digest samples. The instrument is also capable of recording spectra of samples containing compounds with a broad range of masses while using one set of experimental conditions and without compromising resolution or mass accuracy. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/14608621/A_high_performance_matrix_assisted_laser_desorption/ionization_orthogonal_time_of_flight_mass_spectrometer_with_collisional_cooling_ DB - PRIME DP - Unbound Medicine ER -