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O/W emulsions compromise the stratum corneum barrier and improve drug penetration.
Pharmazie. 2003 Oct; 58(10):709-15.P

Abstract

BACKGROUND

W/O emulsions improve the stratum corneum barrier, while microemulsions tend to compromise it. We, therefore, were interested to explore the effects of O/W emulsions on the stratum corneum barrier.

METHODS

Aqueous Cream BP 2001, Clioquinol Cream BP 1999 without clioquinol, Nonionic Hydrophilic Cream DAB 2001 without glycerol, Hydrophilic Skin Emulsion Base NRF S. 25., point of time 2001, without glycerol, and Base Cream DAC were tested versus untreated controls in 29 healthy volunteers for 7 days. Outcome measures included transepidermal water loss (TEWL), skin redness (chromametry a*-value) and erythrocyte circulation in the subpapillary vessels (laser Doppler). Barrier compromise was subsequently explored by performing the hydrocortisone blanching test using Hydrocortisone Cream 0.5% NRF 11.36. (outcome measure: a*-value) in 15 subjects and the sodium lauryl sulfate (SLS) irritation test (outcome measures: TEWL, a*-value, laser Doppler) in 14 subjects.

RESULTS

Pretreatment with the test emulsions produced increases in TEWL (statistically significant for all test emulsions), a*-value (statistically significant for Aqueous Cream BP 2001 and Base Cream DAC), and laser Doppler value (statistically significant for all emulsions except Base Cream DAC). Hydrocortisone penetration was statistically significantly increased with all test emulsions versus untreated contols. SLS irritation was mostly statistically significantly increased versus untreated controls when analyzing the study endpoint-baseline difference.

CONCLUSIONS

O/W emulsions may compromise the stratum corneum barrier and improve drug penetration.

Authors+Show Affiliations

Department of Dermatology, Klinikum der Stadt Karlsruhe GmbH, Germany. mgloor@onlinehome.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

14609282

Citation

Gloor, M, et al. "O/W Emulsions Compromise the Stratum Corneum Barrier and Improve Drug Penetration." Die Pharmazie, vol. 58, no. 10, 2003, pp. 709-15.
Gloor M, Hauth A, Gehring W. O/W emulsions compromise the stratum corneum barrier and improve drug penetration. Pharmazie. 2003;58(10):709-15.
Gloor, M., Hauth, A., & Gehring, W. (2003). O/W emulsions compromise the stratum corneum barrier and improve drug penetration. Die Pharmazie, 58(10), 709-15.
Gloor M, Hauth A, Gehring W. O/W Emulsions Compromise the Stratum Corneum Barrier and Improve Drug Penetration. Pharmazie. 2003;58(10):709-15. PubMed PMID: 14609282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - O/W emulsions compromise the stratum corneum barrier and improve drug penetration. AU - Gloor,M, AU - Hauth,A, AU - Gehring,W, PY - 2003/11/12/pubmed PY - 2003/12/3/medline PY - 2003/11/12/entrez SP - 709 EP - 15 JF - Die Pharmazie JO - Pharmazie VL - 58 IS - 10 N2 - BACKGROUND: W/O emulsions improve the stratum corneum barrier, while microemulsions tend to compromise it. We, therefore, were interested to explore the effects of O/W emulsions on the stratum corneum barrier. METHODS: Aqueous Cream BP 2001, Clioquinol Cream BP 1999 without clioquinol, Nonionic Hydrophilic Cream DAB 2001 without glycerol, Hydrophilic Skin Emulsion Base NRF S. 25., point of time 2001, without glycerol, and Base Cream DAC were tested versus untreated controls in 29 healthy volunteers for 7 days. Outcome measures included transepidermal water loss (TEWL), skin redness (chromametry a*-value) and erythrocyte circulation in the subpapillary vessels (laser Doppler). Barrier compromise was subsequently explored by performing the hydrocortisone blanching test using Hydrocortisone Cream 0.5% NRF 11.36. (outcome measure: a*-value) in 15 subjects and the sodium lauryl sulfate (SLS) irritation test (outcome measures: TEWL, a*-value, laser Doppler) in 14 subjects. RESULTS: Pretreatment with the test emulsions produced increases in TEWL (statistically significant for all test emulsions), a*-value (statistically significant for Aqueous Cream BP 2001 and Base Cream DAC), and laser Doppler value (statistically significant for all emulsions except Base Cream DAC). Hydrocortisone penetration was statistically significantly increased with all test emulsions versus untreated contols. SLS irritation was mostly statistically significantly increased versus untreated controls when analyzing the study endpoint-baseline difference. CONCLUSIONS: O/W emulsions may compromise the stratum corneum barrier and improve drug penetration. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/14609282/O/W_emulsions_compromise_the_stratum_corneum_barrier_and_improve_drug_penetration_ DB - PRIME DP - Unbound Medicine ER -