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N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vivo clastogenicity: protective effects of aqueous neem leaf extract.
Pharmazie. 2003 Oct; 58(10):750-2.P

Abstract

We evaluated the modifying effects of aqueous neem leaf extract on the in vivo clastogenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a potent gastric carcinogen by quantitation of micronuclei and chromosomal aberrations in metaphase cells from the bone marrow of male Wistar rats. Intraperitoneal injection of MNNG (40 mg/kg body weight) induced a significant increase in the frequency of micronuclei and chromosomal aberrations. Pretreatment with aqueous neem leaf extract (100 mg/kg body weight) significantly reduced MNNG-induced increase in micronuclei and chromosomal aberrations. These results reveal the chemoprotective potential of aqueous neem leaf extract against the clastogenic effects of MNNG.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14609290

Citation

Arivazhagan, S, et al. "N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in Vivo Clastogenicity: Protective Effects of Aqueous Neem Leaf Extract." Die Pharmazie, vol. 58, no. 10, 2003, pp. 750-2.
Arivazhagan S, Nagini S, Santhiya ST, et al. N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vivo clastogenicity: protective effects of aqueous neem leaf extract. Pharmazie. 2003;58(10):750-2.
Arivazhagan, S., Nagini, S., Santhiya, S. T., & Ramesh, A. (2003). N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vivo clastogenicity: protective effects of aqueous neem leaf extract. Die Pharmazie, 58(10), 750-2.
Arivazhagan S, et al. N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in Vivo Clastogenicity: Protective Effects of Aqueous Neem Leaf Extract. Pharmazie. 2003;58(10):750-2. PubMed PMID: 14609290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vivo clastogenicity: protective effects of aqueous neem leaf extract. AU - Arivazhagan,S, AU - Nagini,S, AU - Santhiya,S T, AU - Ramesh,A, PY - 2003/11/12/pubmed PY - 2003/12/3/medline PY - 2003/11/12/entrez SP - 750 EP - 2 JF - Die Pharmazie JO - Pharmazie VL - 58 IS - 10 N2 - We evaluated the modifying effects of aqueous neem leaf extract on the in vivo clastogenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a potent gastric carcinogen by quantitation of micronuclei and chromosomal aberrations in metaphase cells from the bone marrow of male Wistar rats. Intraperitoneal injection of MNNG (40 mg/kg body weight) induced a significant increase in the frequency of micronuclei and chromosomal aberrations. Pretreatment with aqueous neem leaf extract (100 mg/kg body weight) significantly reduced MNNG-induced increase in micronuclei and chromosomal aberrations. These results reveal the chemoprotective potential of aqueous neem leaf extract against the clastogenic effects of MNNG. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/14609290/N_methyl_N'_nitro_N_nitrosoguanidine__MNNG__induced_in_vivo_clastogenicity:_protective_effects_of_aqueous_neem_leaf_extract_ DB - PRIME DP - Unbound Medicine ER -