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Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma.
J Allergy Clin Immunol. 2003 Nov; 112(5):819-27; quiz 828.JA

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive syndrome of expiratory airflow limitation caused by chronic inflammation of the airways and lung parenchyma. The airway inflammatory response in COPD is initiated by smoking in the overwhelming majority of cases, and chronic exposure to cigarette smoke initiates a series of events that causes damage to central airways, peripheral airways, and terminal airspaces, leading to physiologic and clinical abnormalities. Although COPD shares some clinical features with asthma, another prevalent airway inflammatory disease, there are distinct differences in the phenotypic characteristics of airway inflammation between COPD and asthma. The eosinophil is the most prominent inflammatory cell in asthma, with mast cells, lymphocytes, and macrophages playing important but less prominent roles. In COPD the cellular composition of the airway inflammatory infiltrate differs, with neutrophils, macrophages, and lymphocytes assuming prominence and the eosinophil playing a minor role, except in the setting of exacerbations. The contrasting inflammatory phenotypes of asthma and COPD have important implications for clinical and physiologic manifestations of disease, as well as for therapy.

Authors+Show Affiliations

Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colo, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

14610463

Citation

Sutherland, E Rand, and Richard J. Martin. "Airway Inflammation in Chronic Obstructive Pulmonary Disease: Comparisons With Asthma." The Journal of Allergy and Clinical Immunology, vol. 112, no. 5, 2003, pp. 819-27; quiz 828.
Sutherland ER, Martin RJ. Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. J Allergy Clin Immunol. 2003;112(5):819-27; quiz 828.
Sutherland, E. R., & Martin, R. J. (2003). Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. The Journal of Allergy and Clinical Immunology, 112(5), 819-27; quiz 828.
Sutherland ER, Martin RJ. Airway Inflammation in Chronic Obstructive Pulmonary Disease: Comparisons With Asthma. J Allergy Clin Immunol. 2003;112(5):819-27; quiz 828. PubMed PMID: 14610463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. AU - Sutherland,E Rand, AU - Martin,Richard J, PY - 2003/11/12/pubmed PY - 2003/12/20/medline PY - 2003/11/12/entrez SP - 819-27; quiz 828 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 112 IS - 5 N2 - Chronic obstructive pulmonary disease (COPD) is a progressive syndrome of expiratory airflow limitation caused by chronic inflammation of the airways and lung parenchyma. The airway inflammatory response in COPD is initiated by smoking in the overwhelming majority of cases, and chronic exposure to cigarette smoke initiates a series of events that causes damage to central airways, peripheral airways, and terminal airspaces, leading to physiologic and clinical abnormalities. Although COPD shares some clinical features with asthma, another prevalent airway inflammatory disease, there are distinct differences in the phenotypic characteristics of airway inflammation between COPD and asthma. The eosinophil is the most prominent inflammatory cell in asthma, with mast cells, lymphocytes, and macrophages playing important but less prominent roles. In COPD the cellular composition of the airway inflammatory infiltrate differs, with neutrophils, macrophages, and lymphocytes assuming prominence and the eosinophil playing a minor role, except in the setting of exacerbations. The contrasting inflammatory phenotypes of asthma and COPD have important implications for clinical and physiologic manifestations of disease, as well as for therapy. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/14610463/Airway_inflammation_in_chronic_obstructive_pulmonary_disease:_comparisons_with_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674903020116 DB - PRIME DP - Unbound Medicine ER -