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[Intrahepatic cholestasis in pregnancy. What to consider in jaundice and pruritus].
MMW Fortschr Med. 2002 Dec 12; 144(50):41-4.MF

Abstract

Intrahepatic cholestasis of pregnancy is a hepatopathy that occurs in the second or third trimester and accounts for 20% of cases of jaundice occurring in pregnancy. Both genetic and hormonal factors appear to play important roles in its development. The leading symptom is pruritus, and jaundice is common. Transaminases, serum bile acids and bilirubin are typically elevated, while gamma-GT is usually normal. For the differential diagnosis, in particular viral hepatitis, cholelithiasis, gestosis and acute fatty liver of pregnancy must be excluded. While the prognosis of intrahepatic cholestasis of pregnancy for the mother is good, the associated increased tendency for a premature birth represents a potential risk for the child. Early treatment with ursodeoxycholic acid appears to have a positive influence on both the mother's symptoms and the course of the pregnancy. Should the symptoms persist after delivery, consideration must be given to a chronic hepatopathy.

Authors+Show Affiliations

Medizinische Klinik II-Grosshadern, Klinikum der Universität München. sikenngott@aol.comNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

14610864

Citation

Kenngott, S, et al. "[Intrahepatic Cholestasis in Pregnancy. what to Consider in Jaundice and Pruritus]." MMW Fortschritte Der Medizin, vol. 144, no. 50, 2002, pp. 41-4.
Kenngott S, Lohse P, Beuers U. [Intrahepatic cholestasis in pregnancy. What to consider in jaundice and pruritus]. MMW Fortschr Med. 2002;144(50):41-4.
Kenngott, S., Lohse, P., & Beuers, U. (2002). [Intrahepatic cholestasis in pregnancy. What to consider in jaundice and pruritus]. MMW Fortschritte Der Medizin, 144(50), 41-4.
Kenngott S, Lohse P, Beuers U. [Intrahepatic Cholestasis in Pregnancy. what to Consider in Jaundice and Pruritus]. MMW Fortschr Med. 2002 Dec 12;144(50):41-4. PubMed PMID: 14610864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Intrahepatic cholestasis in pregnancy. What to consider in jaundice and pruritus]. AU - Kenngott,S, AU - Lohse,P, AU - Beuers,U, PY - 2003/11/13/pubmed PY - 2004/3/9/medline PY - 2003/11/13/entrez SP - 41 EP - 4 JF - MMW Fortschritte der Medizin JO - MMW Fortschr Med VL - 144 IS - 50 N2 - Intrahepatic cholestasis of pregnancy is a hepatopathy that occurs in the second or third trimester and accounts for 20% of cases of jaundice occurring in pregnancy. Both genetic and hormonal factors appear to play important roles in its development. The leading symptom is pruritus, and jaundice is common. Transaminases, serum bile acids and bilirubin are typically elevated, while gamma-GT is usually normal. For the differential diagnosis, in particular viral hepatitis, cholelithiasis, gestosis and acute fatty liver of pregnancy must be excluded. While the prognosis of intrahepatic cholestasis of pregnancy for the mother is good, the associated increased tendency for a premature birth represents a potential risk for the child. Early treatment with ursodeoxycholic acid appears to have a positive influence on both the mother's symptoms and the course of the pregnancy. Should the symptoms persist after delivery, consideration must be given to a chronic hepatopathy. SN - 1438-3276 UR - https://www.unboundmedicine.com/medline/citation/14610864/[Intrahepatic_cholestasis_in_pregnancy__What_to_consider_in_jaundice_and_pruritus]_ DB - PRIME DP - Unbound Medicine ER -