Tags

Type your tag names separated by a space and hit enter

Coffee consumption and risk of rheumatoid arthritis.

Abstract

OBJECTIVE

Recent reports have suggested an association between consumption of coffee or decaffeinated coffee and the risk of rheumatoid arthritis (RA), although data are sparse and somewhat inconsistent. Furthermore, existing studies measured dietary exposures and potential confounders only at baseline and did not consider possible changes in diet or lifestyle over the followup period. We studied whether coffee, decaffeinated coffee, total coffee, tea, or overall caffeine consumption was associated with the risk of RA, using the Nurses' Health Study, a longitudinal cohort study of 121,701 women.

METHODS

Information on beverage consumption was assessed with a food frequency questionnaire (FFQ) that was completed every 4 years, from baseline in 1980 through 1998. Among the 83,124 women who completed the FFQ at baseline, the diagnosis of incident RA (between 1980 and 2000) was confirmed in 480 women by a connective tissue disease screening questionnaire and medical record review for American College of Rheumatology criteria. Relationships between intake of various beverages and the risk of RA were assessed in age-adjusted models and in multivariate Cox proportional hazards models including the cumulative average intake of each beverage during the followup period, adjusted for numerous potential confounders. In addition, for direct comparisons with prior reports, multivariate analyses were repeated using only baseline beverage information.

RESULTS

We did not find a significant association between decaffeinated coffee consumption of >/=4 cups/day (compared with no decaffeinated coffee consumption) and subsequent risk of incident RA, in either an adjusted multivariate model (relative risk [RR] 1.1, 95% confidence interval [95% CI] 0.5-2.2) or a multivariate model using only baseline reports of decaffeinated coffee consumption (RR 1.0, 95% CI 0.6-1.7). Similarly, there was no relationship between cumulative caffeinated coffee consumption and RA risk (RR 1.1, 95% CI 0.8-1.6 for >/=4 cups per day versus none) or between tea consumption and RA risk (RR 1.1, 95% CI 0.7-1.8 for >3 cups/day versus none). Total coffee and total caffeine consumption were also not associated with the risk of RA.

CONCLUSION

In this large, prospective study, we find little evidence of an association between coffee, decaffeinated coffee, or tea consumption and the risk of RA among women.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ekarlson@partners.org

    , ,

    Source

    Arthritis and rheumatism 48:11 2003 Nov pg 3055-60

    MeSH

    Adult
    Arthritis, Rheumatoid
    Caffeine
    Central Nervous System Stimulants
    Coffee
    Drinking Behavior
    Female
    Humans
    Middle Aged
    Nurses
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Tea
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    14613266

    Citation

    Karlson, Elizabeth W., et al. "Coffee Consumption and Risk of Rheumatoid Arthritis." Arthritis and Rheumatism, vol. 48, no. 11, 2003, pp. 3055-60.
    Karlson EW, Mandl LA, Aweh GN, et al. Coffee consumption and risk of rheumatoid arthritis. Arthritis Rheum. 2003;48(11):3055-60.
    Karlson, E. W., Mandl, L. A., Aweh, G. N., & Grodstein, F. (2003). Coffee consumption and risk of rheumatoid arthritis. Arthritis and Rheumatism, 48(11), pp. 3055-60.
    Karlson EW, et al. Coffee Consumption and Risk of Rheumatoid Arthritis. Arthritis Rheum. 2003;48(11):3055-60. PubMed PMID: 14613266.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Coffee consumption and risk of rheumatoid arthritis. AU - Karlson,Elizabeth W, AU - Mandl,Lisa A, AU - Aweh,Gideon N, AU - Grodstein,Francine, PY - 2003/11/13/pubmed PY - 2003/12/3/medline PY - 2003/11/13/entrez SP - 3055 EP - 60 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 48 IS - 11 N2 - OBJECTIVE: Recent reports have suggested an association between consumption of coffee or decaffeinated coffee and the risk of rheumatoid arthritis (RA), although data are sparse and somewhat inconsistent. Furthermore, existing studies measured dietary exposures and potential confounders only at baseline and did not consider possible changes in diet or lifestyle over the followup period. We studied whether coffee, decaffeinated coffee, total coffee, tea, or overall caffeine consumption was associated with the risk of RA, using the Nurses' Health Study, a longitudinal cohort study of 121,701 women. METHODS: Information on beverage consumption was assessed with a food frequency questionnaire (FFQ) that was completed every 4 years, from baseline in 1980 through 1998. Among the 83,124 women who completed the FFQ at baseline, the diagnosis of incident RA (between 1980 and 2000) was confirmed in 480 women by a connective tissue disease screening questionnaire and medical record review for American College of Rheumatology criteria. Relationships between intake of various beverages and the risk of RA were assessed in age-adjusted models and in multivariate Cox proportional hazards models including the cumulative average intake of each beverage during the followup period, adjusted for numerous potential confounders. In addition, for direct comparisons with prior reports, multivariate analyses were repeated using only baseline beverage information. RESULTS: We did not find a significant association between decaffeinated coffee consumption of >/=4 cups/day (compared with no decaffeinated coffee consumption) and subsequent risk of incident RA, in either an adjusted multivariate model (relative risk [RR] 1.1, 95% confidence interval [95% CI] 0.5-2.2) or a multivariate model using only baseline reports of decaffeinated coffee consumption (RR 1.0, 95% CI 0.6-1.7). Similarly, there was no relationship between cumulative caffeinated coffee consumption and RA risk (RR 1.1, 95% CI 0.8-1.6 for >/=4 cups per day versus none) or between tea consumption and RA risk (RR 1.1, 95% CI 0.7-1.8 for >3 cups/day versus none). Total coffee and total caffeine consumption were also not associated with the risk of RA. CONCLUSION: In this large, prospective study, we find little evidence of an association between coffee, decaffeinated coffee, or tea consumption and the risk of RA among women. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/14613266/Coffee_consumption_and_risk_of_rheumatoid_arthritis_ L2 - https://doi.org/10.1002/art.11306 DB - PRIME DP - Unbound Medicine ER -