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Effects of posttraumatic stress disorder on cardiovascular stress responses in Gulf War veterans with fatiguing illness.
Auton Neurosci. 2003 Oct 31; 108(1-2):63-72.AN

Abstract

Abnormal cardiovascular stress responses have been reported in Gulf War veterans with chronic fatigue. However, many of these veterans also suffer from posttraumatic stress disorder (PTSD), which could potentially explain the reported abnormalities. To test this hypothesis, 55 Gulf veterans (GVs) with chronic fatigue syndrome (CFS) or idiopathic chronic fatigue (ICF) were stratified into groups with (N=16) and without (N=39) comorbid PTSD, and were compared to healthy Gulf veterans (N=47) on cardiovascular responses to a series of stressors. The CFS/ICF with PTSD group had lower blood pressure responses to speech and arithmetic tasks, and more precipitous declines and slower recoveries in blood pressure after standing up than the controls. Similar trends in the CF/ICF group without PTSD were not significant, however. Both CFS/ICF groups had blunted increases in peripheral vascular resistance during mental tasks. However, only the veterans with comorbid PTSD had diminished cardiac output responses to the mental stressors and excessive vasodilatory responses to standing. Symptoms of posttraumatic stress were significant predictors of hypotensive postural responses, but only in veterans reporting a significant exposure to wartime stress. We conclude that comorbid PTSD contributes to dysregulation of cardiovascular responses to mental and postural stressors in Gulf veterans with medically unexplained fatiguing illness, and may provide a physiological basis for increased somatic complaints in Gulf veterans with symptoms of posttraumatic stress.

Authors+Show Affiliations

VA Medical Center, East Orange, NJ 07018, USA. apeckerm@njneuromed.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

14614966

Citation

Peckerman, Arnold, et al. "Effects of Posttraumatic Stress Disorder On Cardiovascular Stress Responses in Gulf War Veterans With Fatiguing Illness." Autonomic Neuroscience : Basic & Clinical, vol. 108, no. 1-2, 2003, pp. 63-72.
Peckerman A, Dahl K, Chemitiganti R, et al. Effects of posttraumatic stress disorder on cardiovascular stress responses in Gulf War veterans with fatiguing illness. Auton Neurosci. 2003;108(1-2):63-72.
Peckerman, A., Dahl, K., Chemitiganti, R., LaManca, J. J., Ottenweller, J. E., & Natelson, B. H. (2003). Effects of posttraumatic stress disorder on cardiovascular stress responses in Gulf War veterans with fatiguing illness. Autonomic Neuroscience : Basic & Clinical, 108(1-2), 63-72.
Peckerman A, et al. Effects of Posttraumatic Stress Disorder On Cardiovascular Stress Responses in Gulf War Veterans With Fatiguing Illness. Auton Neurosci. 2003 Oct 31;108(1-2):63-72. PubMed PMID: 14614966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of posttraumatic stress disorder on cardiovascular stress responses in Gulf War veterans with fatiguing illness. AU - Peckerman,Arnold, AU - Dahl,Kristina, AU - Chemitiganti,Rahul, AU - LaManca,John J, AU - Ottenweller,John E, AU - Natelson,Benjamin H, PY - 2003/11/15/pubmed PY - 2004/1/31/medline PY - 2003/11/15/entrez SP - 63 EP - 72 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 108 IS - 1-2 N2 - Abnormal cardiovascular stress responses have been reported in Gulf War veterans with chronic fatigue. However, many of these veterans also suffer from posttraumatic stress disorder (PTSD), which could potentially explain the reported abnormalities. To test this hypothesis, 55 Gulf veterans (GVs) with chronic fatigue syndrome (CFS) or idiopathic chronic fatigue (ICF) were stratified into groups with (N=16) and without (N=39) comorbid PTSD, and were compared to healthy Gulf veterans (N=47) on cardiovascular responses to a series of stressors. The CFS/ICF with PTSD group had lower blood pressure responses to speech and arithmetic tasks, and more precipitous declines and slower recoveries in blood pressure after standing up than the controls. Similar trends in the CF/ICF group without PTSD were not significant, however. Both CFS/ICF groups had blunted increases in peripheral vascular resistance during mental tasks. However, only the veterans with comorbid PTSD had diminished cardiac output responses to the mental stressors and excessive vasodilatory responses to standing. Symptoms of posttraumatic stress were significant predictors of hypotensive postural responses, but only in veterans reporting a significant exposure to wartime stress. We conclude that comorbid PTSD contributes to dysregulation of cardiovascular responses to mental and postural stressors in Gulf veterans with medically unexplained fatiguing illness, and may provide a physiological basis for increased somatic complaints in Gulf veterans with symptoms of posttraumatic stress. SN - 1566-0702 UR - https://www.unboundmedicine.com/medline/citation/14614966/Effects_of_posttraumatic_stress_disorder_on_cardiovascular_stress_responses_in_Gulf_War_veterans_with_fatiguing_illness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(03)00155-3 DB - PRIME DP - Unbound Medicine ER -