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Tolerance to a rice hydrolysate formula in children allergic to cow's milk and soy.
Clin Exp Allergy 2003; 33(11):1576-80CE

Abstract

BACKGROUND

Even hydrolysed cow's milk formulae may retain residual allergens and there are few nutritional options for children with cow's milk allergy (CMA) who also react to soy.

OBJECTIVE

To assess clinical tolerance to a rice-based hydrolysate in children with such a clinical presentation.

PATIENTS AND METHODS

Eighteen children (six girls and 12 boys; median age 5 years; range 1-9 years) with CMA, who developed clinical reactions to a soy-based formula after 2-18 months' treatment, were recruited between January 1998 and June 1999. Clinical evaluation was by skin prick test (SPT) with cow's milk, casein, lactalbumin, soy and rice allergen extracts, fresh cow's milk, soy and hydrolysated rice formula (HRF). Serology was investigated by CAP system technology and immunoblotting. Assessment of the rice formula was carried out by double-blind, placebo-controlled food challenge with rice hydrolysate.

RESULTS

Thirteen children had positive SPT to casein, 10 to lactalbumin, eight to rice and two to rice hydrolysate. Positive serology was found in all patients' sera tested with cow's milk, with soy in 13 sera and with rice in seven. Double-blinded, placebo-controlled challenge with an HRF was negative in all cases.

CONCLUSIONS

Children allergic to cow's milk and soy tolerate an HRF clinically. This suggests that rice hydrolysate may be used as a protein source for children with multiple food-induced reactions.

Authors+Show Affiliations

Department of Pediatrics, The Melloni Hospital, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

14616871

Citation

Fiocchi, A, et al. "Tolerance to a Rice Hydrolysate Formula in Children Allergic to Cow's Milk and Soy." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 33, no. 11, 2003, pp. 1576-80.
Fiocchi A, Travaini M, D'Auria E, et al. Tolerance to a rice hydrolysate formula in children allergic to cow's milk and soy. Clin Exp Allergy. 2003;33(11):1576-80.
Fiocchi, A., Travaini, M., D'Auria, E., Banderali, G., Bernardo, L., & Riva, E. (2003). Tolerance to a rice hydrolysate formula in children allergic to cow's milk and soy. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 33(11), pp. 1576-80.
Fiocchi A, et al. Tolerance to a Rice Hydrolysate Formula in Children Allergic to Cow's Milk and Soy. Clin Exp Allergy. 2003;33(11):1576-80. PubMed PMID: 14616871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tolerance to a rice hydrolysate formula in children allergic to cow's milk and soy. AU - Fiocchi,A, AU - Travaini,M, AU - D'Auria,E, AU - Banderali,G, AU - Bernardo,L, AU - Riva,E, PY - 2003/11/18/pubmed PY - 2004/2/3/medline PY - 2003/11/18/entrez SP - 1576 EP - 80 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 33 IS - 11 N2 - BACKGROUND: Even hydrolysed cow's milk formulae may retain residual allergens and there are few nutritional options for children with cow's milk allergy (CMA) who also react to soy. OBJECTIVE: To assess clinical tolerance to a rice-based hydrolysate in children with such a clinical presentation. PATIENTS AND METHODS: Eighteen children (six girls and 12 boys; median age 5 years; range 1-9 years) with CMA, who developed clinical reactions to a soy-based formula after 2-18 months' treatment, were recruited between January 1998 and June 1999. Clinical evaluation was by skin prick test (SPT) with cow's milk, casein, lactalbumin, soy and rice allergen extracts, fresh cow's milk, soy and hydrolysated rice formula (HRF). Serology was investigated by CAP system technology and immunoblotting. Assessment of the rice formula was carried out by double-blind, placebo-controlled food challenge with rice hydrolysate. RESULTS: Thirteen children had positive SPT to casein, 10 to lactalbumin, eight to rice and two to rice hydrolysate. Positive serology was found in all patients' sera tested with cow's milk, with soy in 13 sera and with rice in seven. Double-blinded, placebo-controlled challenge with an HRF was negative in all cases. CONCLUSIONS: Children allergic to cow's milk and soy tolerate an HRF clinically. This suggests that rice hydrolysate may be used as a protein source for children with multiple food-induced reactions. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/14616871/Tolerance_to_a_rice_hydrolysate_formula_in_children_allergic_to_cow's_milk_and_soy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2003&volume=33&issue=11&spage=1576 DB - PRIME DP - Unbound Medicine ER -